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Chap. 25 Metabolism
Vocabulary and Processes
39
Biology
Undergraduate 2
03/29/2013

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Term
Metabolism
Definition
all chemical processes in the body
Term
Anabolic Reactions
Definition
  • Synthesis rxn (forms chem. bonds)
  • Combine small molecules to large ones
  • Req. energy- endergonic
Term
Catabolic Rxns
Definition
  • Breakdown rxns (break bonds)
  • Break large molecules in ≥ 2 small ones
  • Release energy- exergonic
Term
Adenosine Triphosphate
Definition
  • ATP
  • Involved in energy transfer in the body
    • Moving energy frm exergonic rxn to energonic ones
    • ATP<-->ADP + P + E
Term
Oxidation
Definition
  • Part of catabolism
  • Remove an electron (H) from a molecule
Term
Reduction
Definition
  • Part of catabolism
  • Add an electron (H) to a molecule
  • "To reduce you add"
Term
Glucose Equation
Definition
C6H12O+ 6O--> 6H2O + 36-38ATP
Term
Glycolysis
Definition
  • Glucose to pyruvic acid
  • Occurs in the cytoplasm
  • Few steps
  • Few ATP created
  • Doesn't require O2
Term
Oxidative Phosphorylation
Definition
  • Occurs in mitochondria
  • Electron transport chain- many steps
    • Molecules in chain= coenzymes
  • Many ATP created (32-34)
  • Requires O2
Term
Carbohydrates
Definition
  • Glucose
  • Catabolism- C6H12O6--> 6CO2 + 6H2O
    • Glycolysis- Glucose-> Pyruvic Acid + 2ATP
    • Kerbs Cycle- Pyruvate-> CO2 + NADH+ FADH+ 2ATP
  • Anabolism
    • Glycogenesis- Glucose-> Glycogen (stored in the liver)
      • Ctrl by insulin
    • GlcogenolysisGlycogen-> Glucose (released into the BLstream)
      • Ctrl by Glycagon (in Pancreas)
    • Gluconeogenesis- conversion of amino acids or glycerol-> Glucose
Term
Fats
Definition
  • Catabolic rxn
    • Lypolysis- Triglycerides (adipose tissues) -> Fatty Acids & Glycerol
    • Gluconeogensis- Glycerol->Glucose
      • Glucose then broken down by carb. pathway
    • Beta Oxidation- Fatty Acids -> Acety CoE A
      • CoE A= 2carbon molecule
  • Anabolic Rxns
    • Lipogensis- synthesis (make) of triglcerides (TG) for storage in adipose tissues
      • Glycerol + Fatty Acids-> TG
      • Excess Glucose or Amino Acids-> TG
Term
Proteins
Definition
  • Chains of Amino Acids
  • Catabolic
    • Gluconeogensis- Amino Acids(R group) -> Pyruvate
      • Pyruvate then brokendown thru carbs pathway
    • Removal of amine (NH2) group
      • Allows entry into Kerbs Cycle
    •  Removal of carboxyl (-COOH) group  
      • Allows entry into Kerbs cycle
  • Anabolism
    • Amino Acids strug together to form proteins
      • Primary, 2ndary struc., ...
Term
Vitamins
Definition
organic molecules (contains carbon)
Term
Fat- Soluble Vitamins
Definition
  • can be stored in body (in adipose tissue)
  • Vit. A,D,E,K
Term
Vit. A
Definition
  • maintains gen. health & vigor of epitheal cells
  • fat-soluble
Term
Vit. D
Definition
  • Fat-soluble
  • Essential for absorpt. of Ca2+ & phosphorus frm GI tract
Term
Vit. E
Definition
  • Fat-soluble
  • Inhibits catabolism of certain fatty acids that help form cell struc., esp. membr.
Term
Vit. K
Definition
  • Fat-soluble
  • CoE essential for synthesis of several clotting factors by liver
Term
Water-Solble Vitamins
Definition
  • can't be stored, must be replished daily
  • Vit B12, C, Folic Acid
Term
Vit. B12
Definition
  • Water-soluble
  • CoE necessary for RBC formation
Term
Vit. C
Definition
  • Promotes protein synthesis, including laying down of collagen in formation of CT
  • Water-soluble
Term
Vit. Folic Acid
Definition
  • Water-soluble
  • Components of enzyme sys. sythesizing nitrogenous bases of DNA & RNA
Term
Minerals
Definition
inorganic molecules(no carbon)
Term
Electrolytes
Definition
  • Minerals dissolved in body fluid
  • Sodium
  • Copper
  • Selenuim
Term
Sodium
Definition
  • Electrolyte
  • Strongly affect distribution of water thru osmosis
  • Part of bicarbonate buffer sys.
  • Function  in AP conduction
Term
Copper
Definition
  • Electrolyte
  • Req. w/ iron for synthesis of hemoglobin
  • Metanin formation
Term
Selenium
Definition
  • Electrolyte
  • Synthesis of thyroid hormone, sperm motility, functional immune sys.
  • Antioxidant
Term
Absorptive States
Definition
describe types of metaboli rxns occuring at particular times in the body
Term
Body Heat
Definition
by-product of catabolism (~57% of energy lost as heat)
Term
Calorie
Definition
  • amt of heat produced
  • measurment of body heat
Term
Metabolic Rate
Definition
  • Rate of heat production (# of calories burned per unit time)
  • Measurement of body temp.
Term
Basal Metabolic Rate
Definition
  • Min. resting metabolic rate
  • Measured via
    • Oxygen consumption
    • Body Temp.
Term
BodyThermostat
Definition
pre-optic area of hypothalmus
Term
Obesity
Definition
10-20% above normal body weight
Term
Hypertrophic Obesity
Definition
  • Caused by overeating
  • Usually in adults
  • Fat cells inc. in size
Term
Hyperplastic Obesity
Definition
  • Due to a genetic mutation
  • Present in children
  • Fat cells inc. in #
Term
Diabetes
Definition
  • Juvenile-onset (Type 1)
    • due genetic mutation
    • Islet cells don't prod. insulin
    • Can't perform anabolic rxn
  • Adult-onset (Type 2)
    • may be assoc. w/ hypertrophic obesity
    • Insulin secretion is normal
    • Insulin receptors desentized
Term
Phenylketonuria
Definition
  • Genetic condition
  • Leads to intellectual impairment
  • Can't break-down amino acid- phenylalanine
  • Treatment: limit intake of phenylalanine
Term
Cystic Fibrosis
Definition
  • Due to genetic mutation
  • Exocrine glands (pancreas) blocked by mucous
  • No pancreatic jucie to intestines
  • No digest. or absorp. of fats
  • No access to fat-soluble vit. ADEK
  • Mucous in respiratory tract
  • Ctrlled by ingestion of need enzymes to break down food
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