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Chap 18
Chap 18
14
Biology
Undergraduate 3
05/01/2014

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Term
Inbreeding Coefficient
Definition
FI = (1/2)^n x (1 + FA)
FA = inbreeding coefficient of ancestor
Term
locus
Definition
location in the genome; a single nucleotide or a stretch of nucleotides
Term
Single Nucleotide Polymorphisms
(SNPs)
Definition
-Simpliest form of genetic variation
-Difference in the nucleotide present (A, G,T,C) at a single site
Term
microsatellite loci
Definition
short sequence motif, 2-6 BP long, repeated multiple times with different alleles having different numbers of repeats
Term
polymorphism
Definition
the occurrence in a population of several phenotypic forms associated with alleles of one gene or homologs of one chromosome
Term
common SNPs
Definition
in a population the less common allele occurs at a frequency of about 5 percent or greater
Term
Rare SNPs
Definition
occur less than 5 percent
Term
haplotype
Definition
combination of alleles at multiple loci of the same chromosomal homolog
Term
gene pool
Definition
sum total of all alleles in the breeding members of a population at a given time
Term
Hardy-Weinberg assumptions
Definition
1. mating is random
2. all genotypes are viable
3. there are no subpopulations
4. only applies to large populations
5. All frequencies same in males and females
6. No migration
7. No mutation
Term
Positive Assortative Mating
Definition
similar types mate;
tall mates with tall or short with short
Term
negative assortative
Definition
unlike individuals mate;
Term
3 types of bias in mating
Definition
1. positive and negative assortative
2. isolation by distance
3. inbreeding
Term
Important Caveat:
Definition
-Ki square test only detect large deviations from H-W
-One or more assumptions could be violated and still not get significant deviations from H.W
-Agreement with H.W expectation is not proof that assumptions hold
-But significant deviation from H.W implies 1 or more assumptions violated.
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