Term
Extracellular matrix
Gel-like “_______”
Primarily made up of _____: two types
Glycosaminoglycans (___)
________ |
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Definition
-ground substance
-polysaccharides
-GAGS
-proteoglycans |
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Term
Extra Cellular Matrix
Fibrous proteins (as we saw on previous slide)
-
Structure and _______ |
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Definition
-Collagen, elastin, fibronectin, laminin
-adhesive functions |
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Term
GAGS
Repeating ____ units
One is an _______
Charged - ______ groups
Most ____ molecules of animal cells(Charge?) |
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Definition
-disaccharide
-amino sugar
-sulfate and carboxyl
-negative
-anionic |
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Term
So what? Neg charge
Attract _______ (Na+)
Attracts _____
Hydration creates swelling pressure - ___
Protects joints -___ matrix protects from ____ forces |
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Definition
-positive ions
-H2O
-called turgor
-cartilage
-compressive |
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Term
GAGs (animal cells)
____ - not sulfated
secreted directly from ______
doesn’t have to be bound to a ____ |
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Definition
-Hyaluron
-cell surface
-proteins |
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Term
______ sulfate
____ sulfate
_____ sulfate |
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Definition
-Dermatin or chondroitin
-Heparin
-Keratin |
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Term
| ________- most abundant biopolymers on Earth |
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Definition
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Term
GAGS and Proteoglycans
Functions?
Immobilize...
Provide a reservoir of protein for ...
Protects proteins from ...
Bind to proteins and _____ activity
... for presentation to cell surface receptors |
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Definition
-regulate activity of secreted proteins
...secreted molecules close to where they are secreted
...later use
...proteolytic degradation
-sterically block
-Alter or concentrate protein... |
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Term
GAGS and Proteoglycans
Functions?
Immobilize...
Provide a reservoir of protein for ...
Protects proteins from ...
Bind to proteins and _____ activity
... for presentation to cell surface receptors |
|
Definition
-regulate activity of secreted proteins
...secreted molecules close to where they are secreted
...later use
...proteolytic degradation
-sterically block
-Alter or concentrate protein... |
|
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Term
| Inflammatory response - _____ are immobilized by _____ on ____ cells and allows for homing of lymphocytes |
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Definition
-chemokines
-proteoglycans
-endothelial |
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Term
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Definition
Collagen
Elastin
Fibronectin |
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Term
Collagen
Limits stretching and ______
Skin and bone
Secreted by _____
3 _____: GXX; modified aa (______) |
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Definition
-prevents tearing
-fibroblasts
-alpha helices
-hydroxyproline and hydroxylysine |
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Term
_______ helices
Often _____ perpendicular to each other
Strong - resist _____ forces
Deficiency in making ____ - Vit C (___) |
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Definition
Covalently-crosslinked
fibrils
tensile
-these aa
-Scurvy |
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Term
Elastin
Highly hydrophobic
Secreted and also organized in _____(_______, similar to collagen)
Stucture makes them _____ (? Don’t know how?) |
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Definition
-fibers and sheets
-covalently-crosslinked
-elastic |
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Term
| Stretching important in numerous tissues - |
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Definition
| heart, lungs, kidney etc… |
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Term
Elastin molecules covered with another molecule called ______
Defects in this result in _____syndrome |
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Definition
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Term
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Definition
Helps cells attach to matrix
Complex protein - binds to multiple substrates
RGD |
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Term
RGD Sequence
Binding of _____to the cell occurs via the ____ - binds to ____
Not only used by fibronectin
Blood clotting - ______
Targetted by snake venom (inhibits ____) |
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Definition
fibronectin
RGD sequence
integrins
fibrinogen
blood clotting |
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