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Cerebellum
Cerebellum key facts and terms--Clinical Neuroanatomy
26
Medical
Graduate
03/10/2012

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Term
superior cerebellar peduncle
Definition
brachium conjunctiva
carried outputs from the cerebellum
decussates in the midbraine at the level of the inferior colliculi
Term
middle cerebellar peduncle
Definition
brachium pontis
carries inputs to the cerebellum from the pons
Term
inferior cerebellar peduncle
Definition
restiform body ("ropelike body")
carries inputs to the cerebellum from the medulla
Term
function and motor pathways influenced by the lateral hemisphere of the cerebellum
Definition
Function = motor planning for extremities
MP influenced = lateral corticospinal tract
Term
function and motor pathways influenced by the intermediate hemisphere of the cerebellum
Definition
function = distal limb coordination (fingers and toes)
MP influenced = lateral corticospinal tract, rubrospinal tract
Term
function and motor pathways influenced by the vermis
Definition
function = proximal limb and trunk coordination
MP influenced = anterior corticospinal tract, reticulospinal tract, vestibulospinal tract, and tectospinal tract
Term
function and motor pathways influenced by the flocculonodular lobe
Definition
function = balance and vestbulo-ocular reflexes
MP influenced = medial longitudinal fasiculus
Term
Deep cerebellar nuclei
Definition
dentate
emoliform and globose (interposed nuclei)
fastigial
Term
dentate nuclei
Definition
largest and deepest cerebellar nuclei
receive projections from the lateral cerebellar hemispheres
active before movement
Term
interposed nuclei
Definition
emboliform and globose nuclei
receive input from the intermediate part of the cerbellar hemispheres
active during and in relation to movement
Term
Fastigial nuclei
Definition
receive input from the vermis and a small input from the flocculonodular lobe which then project to the vestibular nuclei
Term
mossy fibers
Definition
ascend through the cerebellar white matter
form excitatory synapses on the dendrites of granular cells
Term
granular cells
Definition
receive excitatory inputs from the mossy cells
send axons into the molecular layer that form parallel fibers = runs parallel to the perkinje cells and excites them
Term
All output from the cerebellar cortex is carried through which axons
Definition
axons of the purkinje cells
Term
Purkinje cells
Definition
form inhibitory synapses onto the deep cerebellar nuclei and vestibular nuclei
Term
climbing fibers
Definition
arise from the contralateral inferior olivary nucleus
wrap around the cell body and proximal dendritic tree of purkinje cells = form excitatory synapses and have a strong modulatory affect on Purkinje cells
Term
basket cells
Definition
located in molecular layer
excited by synaptic inputs from the granule cell parallel fibers
travel perpendicular to the parallel fibers to cause lateral inhibition (strong, inhibitory basketlike connections)
Term
Stellate cells
Definition
in the molecular cell layer
are excited by synaptic inputs from the granule cell parallel fibers
run perpendicular to the parallel fibers
terminate on purkinje cell dendrites and cause lateral inhibition
Term
Golgi cells
Definition
granular cell layer
receive excitatory inputs from granule cell parallel fibers in molecular layer
provide feeback inhibition onto the granular cell dendrites
Term
cerebellar glomerulus
Definition
visible small clearings among the granule cells
contain axons and dentrites encapsulated in a glial sheath
contain large mossy fiber axon terminals and golgi cell axon terminals (both inputs) and forms synapses with granule cell dendrites (outputs)
Term
cerebellar excitatory connections
Definition
all axons projecting upward are excitatory:
mossy fibers, climbing fibers, and granule cell parallel fibers)
**output of the deep cerebellar nuclei (not part of the cerebellar cortex)
Term
cerebellar inhibitory connections
Definition
all axons projecting downwards are inhibitory:
Purkinje cells, stellate cells, basket cells and Golgi cells
Term
Where do cerebellar output pathways decussate?
Definition
1. superior peduncle
2. with the corticospinal (pyramidal decussation) and rubrospinal (ventral tegmental decussation) tracts
Term
Cerebellar outputs
Definition
all are carried by the Purkinje cells to the deep cerebellar nuclei or vestibular nuclei
Term
lesions of the lateral cerebellum will affect which movements
Definition
movements of the distal limb
Term
lesions of the medial cerebellum will affect which movements?
Definition
trunk control, posture, and gait
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