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Cellular A&P, Diffusion
Aug. 25 lecture
48
Nursing
Graduate
08/25/2014

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Term
What does the cellular membrane consist of?
Definition
A phospholipid bilayer which is the cell membrane.
1) Polar hydrophilic head composed of glycerol moieties
2) Fatty acid hydrophobic tail composed of carbohydrate chains. There are 2 fatty acid tails per phospholipid.
Term
What does amphipathic mean?
Definition
It is composed of 2 molecules or components. ex. lipid bilayer.
Term
WHAT IS CYTOSOL?
Definition
INTRACELLULAR FLUID
Term
WHAT IS BOTH THE CYTOSOL AND EXTRACELLULAR FLUID COMPRISED OF?
Definition
WATER
Term
HOW DO YOU TELL WHICH SIDE OF THE MEMBRANE IS INSIDE VS OUTSIDE?
Definition
GLYCOPROTEINS AND GLYCOLIPIDS EXIST ON THE EXTRACELLULAR SURFACE OF CELLS.
Term
WHAT IS A GLYCOPROTEIN AND A GLYCOLIPID?
Definition
THEY ARE BOTH NOTHING MORE THAN CARBOHYDRATES. IF YOU TAKE CHO AND STICK IT ON A PROTEIN IT IS CALLED A GLYCOPROTEIN. IF YOU TAKE CHO AND STICK IT ON A LIPID IT BECOMES A GLYCOLIPID.
Term
WHAT ARE THE 2 PROTEINS THAT EXIST INSIDE THE PHOSPHOLIPID BILAYER?
Definition
INTEGRAL (TRANSMEMBRANE PROTEIN) AND PERIPHERAL PROTEINS.
Term
WHAT DOES A INTEGRAL PROTEIN DO?
Definition
IT PASSES ALL THE WAY THROUGH BOTH SURFACES AND IT IS HOW WE TRANSPORT SUBSTANCES FROM ONE SIDE OF THE CELL TO THE OTHER SINCE THEY MAKE CONTACT WITH THE OUTSIDE AND INSIDE OF THE CELL.
Term
WHAT CAN THE INEGRAL MEMBRANE PROTEINS BE?
Definition
RECEPTORS, CHANNELS, OR STRUCTURAL PROTEINS
Term
WHAT DO PERIPHERAL PROTEINS DO? WHERE ARE THEY LOCATED? WHAT HAPPENS WHEN THESE PROTEINS ARE DAMAGED?
Definition
GIVE THE CELL ITS SHAPE. ON THE INSIDE AND OUTSIDE. DAMAGE TO THESE PROTEINS CHANGES SHAPE AND FUNCTION.
Term
WHAT IS A FLUID MOSAIC MODEL?
Definition
THE MODEL OF DESCRIPTION OF HOW THE POLAR HEADS CONSTANTLY MOVE.
Term
WHAT ARE THE 4 DIFFERENT TYPES OF CELLS?
Definition
EPITHELIAL, CONNECTIVE, MUSCLE, NERVOUS
Term
WHAT DOES STRATIFIED MEAN?
Definition
MULTIPLE LAYERS
Term
HOW MANY LAYERS DOES SIMPLE EPITHELIAL CELLS EXIST IN?
Definition
ONE
Term
WHAT IS A BASEMENT MEMBRANE?
Definition
THE "GLUE" THAT HOLDS THE CELLS TOGETHER.
Term
WHICH SIDE IS THE APICAL AKA LUMINAL SURFACE AT ON THE CELL AND WHICH SIDE IS THE BASOLATERAL SURFACE OF THE CELL?
Definition
THE APICAL PART IS IN CONTACT WITH THE EXTERNAL ENVIRONMENT AND THE BASOLATERAL IS IN CONTACT WITH THE INTERNAL ENVIRONMENT.
Term
WHAT IS VERY IMPORTANT IN RELATION TO POSITION CONCERNING THE APICAL AND BASOLATERAL SURFACE?
Definition
THAT THEY STAY ON THEIR DESIGNATED SIDE.
Term
WHAT PREVENTS THE 2 PROTEINS FROM SWITCHING SIDES?
Definition
TIGHT JUNCTIONS. EX. LINE ON A SWIMMING POOL SEPARATING DEEP AND SHALLOW END.
Term
WHAT DOES THE CHOLESTEROL DO THAT IS ATTACHED TO THE HYDOPHOBIC TAILS.
Definition
HELPS WITH RIGIDITY.
Term
NAME THE 3 TYPES OF DIFFUSION.
Definition
SIMPLE, CHANNEL-MEDIATED, AND CARRIER MEDIATED
Term
HOW MOLECULES GET FROM ONE SIDE OF THE CELL TO THE OTHER IS DEPENDENT ON WHAT?
Definition
THE MOLECULE. SIZE, ELECTRICAL CHARGE, AND COMPOSITION ALL COME INTO PLACE.
Term
WHAT MOLECULES ARE LIPID SOLUBLE AND PARTICIPATE IN SIMPLE DIFFUSION?
Definition
O2, CO2, AND UREA. THESE WILL MOVE INTO AND OUT OF THE CELL DEPENDING ON THE CONCENTRATION GRADIENTS.
Term
HOW DO MOLECULES MOVE IN RELATION TO THE CONCENTRATION GRADIENT?
Definition
FROM AN AREA WITH HIGH CONCENTRATION TO LOW CONCENTRATION
Term
THE NET MOVEMENT OF SUBSTANCE FROM ONE SIDE TO THE OTHER WILL CONTINUE AS LONG AS WHAT?
Definition
THERE IS A CONCENTRATION GRADIENT. AS SOON AS THE CONCENTRATION GRADIENT REACHES ZERO THE MOVEMENT STOPS.
Term
DEFINE NET DIFFUSION.
Definition
FOR EVERY MOLECULE THAT MOVES ONE WAY ANOTHER MOLECULE MOVES IN THE OPPOSITE DIRECTION. DIFFUSION STILL OCCURS BUT THE NET DIFFUSION IS EQUAL TO ZERO.
Term
WHAT IS VERY IMPORTANT ABOUT A CHARGED SUBSTANCE IN RELATION TO THE LIPID BIPLAYER?
Definition
WHEN A SUBSTANCE HAS A CHARGE IT CANNOT PASS THROUGH THE LIPID BILAYER.
Term
SINCE CHARGED PARTICLES CAN'T PASS THROUGH A LIPID BILAYER AND DON'T PARTICIPATE IN SIMPLE DIFFUSION HOW DO THEY GET TO INSIDE OF THE CELL?
Definition
THROUGH CHANNEL-MEDIATED FACILITATED DIFFUSION.
Term
WHAT TYPE OF PORE IS FORMED IN THE MIDDLE OF THE CHANNEL-MEDIATED PROTEIN?
Definition
AN AQUEOUS ONE
Term
DOES THE CHANNEL-MEDIATED FACILITATED DIFFUSION REQUIRE ENERGY?
Definition
NO. DIFFUSION DOESN'T REQUIRE ENERGY.*** IT MOVES BASED ON A CONCENTRATION GRADIENT.
Term
WHAT SIZE OF MOLECULES TYPICALLY ARE USED FOR CARRIER-MEDIATED FACILITATED DIFFUSION?
Definition
LARGE ONES LIKE GLUCOSE.
Term
WHAT IS THE BIGGEST DIFFERENT BETWEEN CHANNEL-MEDIATED AND CARRIER-MEDIATED? WHAT DO THEY HAVE IN COMMON?
Definition
THE CHANNEL IS CONTINUOSULY OPEN WHEREAS THE CARRIER DRUMPS AND RESETS. THEY BOTH ARE SIMILAR IN THE FACT THAT THEY BOTH WORK WITH THE CONCENTRATION GRADIENT.
Term
IN RELATION TO TRANS-MEMBRANE DIFFUSION, WHAT IS FICK'S LAW OF DIFFUSION DEPENDENT ON? 4 ANSWERS.
Definition
SURFACE AREA, MEMBRANE THICKNESS, MEMBRANE PERMEABILITY (DIFFUSION COEFFICIENT), CONCENTRATION GRADIENT
Term
WHAT IS THE EQUATION FOR FICK'S LAW OF DIFFUSION?
Definition
RATE OF DIFFUSION = CONCENTRATION GRADIENT X SA X DIFFUSION COEFFICIENT/ MEMBRANE THICKNESS
Term
WHAT IS THE EQUATION FOR DIFFUSION COEFF?
Definition
DIFFUSION COEF = PERMEABILITY/SQRT OF THE MOLECULAR WEIGHT
Term
HOW DOES THE SIZE OF THE MOLECULE EFFECT THE TIME DIFFUSION TAKES PLACE?
Definition
THE BIGGER THE MOLECULAR WEIGHT, THE SLOWER THE DIFFUSION TAKES PLACE.
Term
HOW DOES THE DIFFUSION COEFFICIENT EFFECT THE RATE OF DISTRICUTION?
Definition
THE HIGHER THE DIFFUSION COEFFICIENT THE HIGHER THE RATE OF DISTRIBUTION.
Term
HOW DOES THE SURFACE AREA OF THE MOLECULE EFFECT THE DIFFUSION?
Definition
THE SMALLER THE SURFACE AREA, THE FASTER THE DIFFUSION.
Term
THE STEEPNESS OF A CONCENTRATION GRADIENT IS DIRECTLY PROPORTIONAL TO THE RATE OF WHAT?
Definition
DIFFUSION. AS THE CONCENTRATION GRADIENT FOES UP THE RATE OF DIFFUSION GOES UP.
Term
HOW DOES SIZE EFFECT DIFFUSION?
Definition
THE SMALLER THE MOLECULE THE FASTER IT DIFFUSES.
Term
HOW DOES AN INCREASE IN THE DIFFUSION DISTANCE EFFECT DIFFUSION?
Definition
AN INCREASE IN DIFFUSION DISTANCE DECREASES THE RATE OF DIFFUSION.
Term
IN SIMPLE DIFFUSION AS THE CONCENTRATION INCREASES WHAT HAPPENS TO THE RATE OF DIFFUSION?
Definition
IT INCREASES
Term
DESCRIBE WHY FACILITATED DIFFUSION IS DEPENDENT ON THE CONCENTRATION GRADIENT UNTIL IT REACHES A PLATEAU.
Definition
THERE IS ONLY A CERTAIN NUMBER OF CHANNELS/CARRIERS. ONCE ALL OF THEM ARE OPEN AND THEY ARE WORKING AS FAST AS THEY CAN IT DOESN'T MATTER IF I DOUBLE THE CONCENTRATION ON THE OUTSIDE, I CAN ONLY PUSH SUBSTANCES THROUGH THE CHANNEL BEFORE IT PLATEAUS OFF.
Term
IS DIFFUSION AN ACTIVE OR PASSIVE PROCESS?
Definition
PASSIVE. IT DOESN'T REQUIRE ENERGY AND MOVES RELATED TO A CONCENTRATION GRADIENT.
Term
NAME THE 3 TYPES OF ION CHANNELS?
Definition
LEAK, VOLTAGE GATED, AND LIGAND GATED
Term
DESCRIBE LEAK ION CHANNELS.
Definition
THEY ARE NOT GATED, THERFORE ARE ALWAYS OPEN. THIS ALLOWS IONS TO MOVE IN BOTH DIRECTIONS. EX A HOLE IN THE WALL WITHOUT A DOOR.
Term
DESCRIBE VOLTAGE GATED ION CHANNELS.
Definition
IT CONTAINS A GATE WHICH MEANS IT CAN BE OPEN TO ALLOW THINGS TO COME IN OR CLOSED WHICH PREVENTS THINGS FROM MOVING OUT. WHEN VOLTAGE CHANGES INSIDE THE CELL, IT CHANGES THE CHARGE AND THE GATE OPEN. IN SUMMARIZATION YOU CHANGE FROM OPEN TO CLOSED STATE BY CHANGING THE VOLTAGE.
Term
DESCRIBE LIGAND GATES ION CHANNELS?
Definition
A LIGAND IS LIKE A KEY WHEREAS THE CHANNEL IS THE LOCK. THE CHANNEL STAYS CLOSED UNTIL THE LOCK (CHANNEL) BINDS THE LIGAND (KEY). WHEN THE LIGAND GOES INTO THE LOCK THE CHANNEL OPENS.
Term
HOW DOES A CHANNEL ALLOW SODIUM TO COME IN AND POTASSIUM TO GO OUT?
Definition
CHANGES IN VOLTAGE AND CHANGES IN LIGAND.
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