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| MHC 1-like; interacts with γ:δ T-cells |
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| Involved in T-cell development; commits to double negative |
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| Found on helper T-cells; involved in MHC 2 communication and cell-cell adhesion |
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| Involved in T-cell development in the thymus; indicate an immature T-cell; also found on B-1 B-cells |
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| Found on cytotoxic T-cells; involved in MHC 1 communication and cell-cell adhesion |
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| Found on common lymphoid precursor cells |
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| Found on macrophages; complement 3 & 4 receptor |
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| GPI anchored glycoprotein found on macrophages, monocytes and neutrophils; forms a complex with MD2 and TLR4 to aid in the detection of LPS (PAMP) |
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| aka FcγRIII; found on NK cells; detects IgG and initiates destruction of infected cells |
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| Found on macrophages; LFA-1 integrin (involved in extravasation from blood vessel) |
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| Found on pro-B-cells during development; involved in B-cell signaling with CD81 and CD21 |
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| Found on B-cells; targeted by Rituximab; ADCC on NK cells attack the CD20 receptors on B-cell lymphoma cells and destroy the cancer cells |
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| aka CR2; binds to C3d (signal 2 in B-cell signaling) and stimulates isotype switching; used by EBV to gain entry into B-cells; marker for mature B-cells |
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| aka FcεRII; found on and shed by B-cells; trimeric form of soluble CD23 signals for the differentiation of B-cells into IgE producing cells; the monomeric form of soluble CD23 inhibits this process |
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| aka IL-2Rα; found on T-regs (and apparently on pre-B-cells) |
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| Found on naïve γ:δ T-cells |
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| Receptor found on developing T-cells; involved in the 2nd signal for development; binds to B7-1/B7-2 on APCs and CTLA4 on Tregs |
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| Receptor found on epithelial surfaces that binds to L-selectin (CD62); also a pluripotent hematopoietic stem cell marker |
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| Marker for germinal centers |
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| Found on macrophages and B-cells; interacts with CD40L as part of the 2nd signal for activation of B-cells and macrophages by T-cells |
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| Found on CD4 T-cells; interacts with CD40 as part of the 2nd signal for activation of B-cells and macrophages by T-cells |
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| Marker for the light zone of germinal centers |
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| Receptor-linked protein tyrosine phosphatase that is expressed on all leukocytes; involved in T-cell activation |
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| Marker for memory T-cells |
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| Marker for naïve T-cells and terminally differentiated γ:δ T-cells |
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| Found on somatic cells; serves as a signal to NK that the cell is in distress; binds to 2B4 on NK cells and initiates cells destruction |
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| aka FcγRIIA; found on myeloid cells; low affinity IgG receptor |
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| aka DAF; regulates the amount of C3 convertase that is created in order to conserve C3 |
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| aka protectin; prevents MAC from killing healthy cells |
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| aka L-selectin, found on T-cells and neutrophils |
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| aka FcγRI; found on monocytes, macrophages, and dendritic cells; high affinity receptor for IgG |
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| Marker for germinal centers |
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| aka B7-1; interacts with CD28 on T-cells to help them develop ("signal 2") and CD152 (downregulation) |
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| Found on B-cells (and endothelial and epithelial cells); involved in B-cell signaling for isotype switching (along with CD19 and CR2 aka CD21) |
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| aka B7-2; found on APCs; interacts with CD28 on T-cells ("signal 2) and CD152 (downregulation) |
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| "death receptor" that interacts with FASL |
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| Found on NK cells; "Good afternoon" universal KIR receptor that prevents NK cells from killing healthy cells |
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| aka IL-7; growth factor involved in the development of a B-cell precursor cell |
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| aka CTLA-4; constitutionally expressed on T regulator cells; also expressed on conventional T-cells after activation; downregulates T-cell activation after binding with CD80/CD86 (B7) |
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| aka CD40L, Found on T-cells, interacts with CD40 on B-cells; important for isotype switching |
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| aka BTN3A1, found on all tissues; binds MHBPP created by bacteria, and aids in presentation to Vγ:Vδ T-cells in the blood |
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| Found on macrophages and endothelial cells; forms a complex with CD14 and MD2 to sense LPS; in the presence of LPS, endothelial cells cause a downregulation of anticoagulation via decreased tissue factor pathway inhibitor and increased thrombin, while macrophages and monocytes produce increased quantities of effector cytokines |
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| Marker for immature B-cells; the main function of soluble IgM is complement activation |
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| Marker for mature B-cells (along with IgM); the main function of soluble IgD is sensitization of mast cells |
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| Detect flagella of bacteria in the intestines |
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| Detects dsRNA viruses on natural killer cells |
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| Detects dsDNA viruses and bacteria |
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| Found on macrophages, FDC's, B cells, and RBC's; on macrophages, it senses C3b; on FDC's it senses C3b and causes it to bind in order to enhance antigen presentation to B-cells;on B-cells it senses C3b and stimulates the production of C3d; on RBC's it attaches immune complexes for later disposal by macrophages |
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| aka CD21; recognizes C3d and amplifies signal on B-cells in conjunction with CD19 and CD81 in order to facilitate isotype switching |
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| Found on neutrophils; recognizes iC3b |
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| Found on neutrophils; recognizes iC3b |
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| Receptor found on immature B-cells that recognizes CCL19 and CCL21 hand homes these cells into lymph nodes |
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| Actively transports IgG across the placenta and mucosal surfaces |
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| aka CD64; Found on monocytes, macrophages, neutrophils, dendritic cells, and eosinophils; cross reacts with 2 IgG molecules and stimulates phagocytosis |
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| Found on macrophages; binds IgG4 and inhibits cytokine release |
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| aka CD32; Found on macrophages and other myeloid cells; binds IgG1 and activates the release of cytokines |
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| Found on naive B-cells; involved in isotype switching from IgM to IgG |
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| CD16; Found on natural killer cells mediates antibody dependent cell mediated cytotoxicity; also found on mast cells, involved with type 3 hypersensitivity and Arthus reaction |
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| Found on mast cells, basophils, and eosinophils; binds IgE and causes degranulation |
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| CD23; Found on B cells; trimeric form of soluble CD23 signals for the differentiation of B-cells into IgE producing cells; the monomeric form of soluble CD23 inhibits this process |
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| Expressed on neutrophils and macrophages (?) |
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| Found on endothelial cells interacts with LFA one on T-cells and neutrophils also expressed by dendritic cells to activate T-cells |
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| Found on endothelial cells; binds to PSGL-1 on leukocytes and induces rolling |
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| Found on endothelial cells; binds to Sialyl-Lewis(x) on leukocytes and induces rolling |
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| aka CD 62; Found on neutrophils and T cells; attaches to CD34 and allows for rolling interaction |
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| Found on neutrophils and T-cells; binds to ICAM on endothelial cells; expression is induced by TNFα |
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| An integrin found on neutrophils; binds to E-selectin on endothelial cells and induces rolling |
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| Marker for mature B-cells |
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| Marker for Langerhans cells |
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