> 12mmHg is intraabdominal hypertension

>20mmHg results in intra-abdominal compartment syndrome

More O2 is released

-Low pH

-Increase PaCO2

-Increase in body temperature

-Increase in 2,3 diphosphoglycerate (2, 3-DPG)

Carried on hemoglobin

>95%

RR x TV

5-10 mL/min

Increased risk for clot formation

1. Blood stasis

2. Hypercoaguability

3. Vessel Injury

8-12 mmHg

18-25 mmHg indicates pulmonary edema/heart failure

Pure alpha 1

Works on vasculature, VASOCONSTRICTION

Dose 2-200 mcg/min

Both alpha and Beta 1 effects

Vasoconstriction and increases HR and contracility

Dose 2-30 mcg/min

Can cause tachyarrhythmias

Equal alpha 1 and Beta 1 &2 effects

Increases HR, MAPs, vasoconstriction, increases afterload and contractility

Dose 2-10 mcg/min

Both alpha and B1 effects

Primairly increase heart rate and contracility and at high doses causes vasoconstriction

1-10 mcg/kg/min

Works on V1 and V2 receptors

Causes vasoaconstrcition and increased MAPS

Dose 0.3-0.4 units/min

Pure beta activity, B1 >B2

Increases HR and contracility, will cause some vasodilation and may decrease preload and afterload

Dose 2-20 mcg/kg/min

Phsphodiesterase inhibitor

Causes increased contracility and vasodilation

Dose 0.375-0.75 mcg/kg/min

Nitric oxide mediated smooth muscle vasodilation, most prominent in venous system, decreases preload and dilates coronary arteries

Dose 5-10 mcg/min, usual dose about