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Cardiovascular RN
Cardio diseases
88
Pathology
Undergraduate 2
02/24/2011

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Term
Systolic failure
Definition
This term refers to failure of the heart to pump properly.
Term
decreased ejection
Definition
The heart contracts too weakly, so that it does not eject sufficient blood
Term
cardiomyopathies
Definition
something wrong with the heart muscle itself.
Term
Diastolic failure
Definition
The heart muscle does not relax properly, which prevents its proper filling during diastole.
Term
Obstruction to flow
Definition
which can be due to stenotic (narrowed) vessels or heart valves
Term
Disordered electrical activity
Definition
Improper generation of propagation of electrical impulses
Term
fibrillation
Definition
which is the rapid, unsynchronized, irregular contraction of the muscle fibers in the heart
Term
heart block
Definition
failure of conduction
Term
Shunts
Definition
Blood flows through abnormal connections between heart chambers or blood vessels. Most often, these abnormal communications are due to congenital defects, but some are acquired.
Term
Aneurysm
Definition
localized dilatation of the vessels or heart wall
Term
Congestive heart failure
Definition
the inability of the heart to pump blood at a rate that is sufficient to meet the needs of the body. The heart may attempt to compensate by becoming hypertrophied and/or increasing the size of the chambers.
Term
brain natriuretic peptide (BNP)
Definition
Dilates blood vessels and increases the excretion of sodium.
Term
pressure overload
Definition
when the heart encounters too much resistance in the aorta
Term
volume overload
Definition
when the amount of fluid that the heart has to deal with is too great
Term
Left ventricular failure
Definition
the pumping function of the heart is insufficient. There is decreased output, increased retention, and too little blood flow to the tissues.
Term
right ventricular failure
Definition
, the heart cannot accept venous return adequately. There may be congestion of the liver, accumulation of fluid in the body cavities (effusions; called ascites in the peritoneal cavity), and peripheral edema, especially in the lower extremities.
Term
embryonic heart
Definition
a tube-like structure that folds in upon itself and then becomes divided into its chambers by formation of septa
Term
truncus arteriosus
Definition
divides to form the aorta and pulmonary artery.
Term
interventricular septum
Definition
divides the ventricle in two.
Term
septum primum
Definition
The atrium is first divided in two
Term
septum secundum
Definition
separation is completed in the atria.
Term
atrioventricular canal
Definition
The atria and ventricles are divided in the region.
Term
Most congenital problems arise from failure of...
Definition
the septa to form properly.
Term
Ventricular septal defect (VSD)
Definition
an opening is present between the right and left ventricles. This is the most common major congenital anomaly of the heart ("hole in the heart").
Term
Atrial septal defect (ASD)
Definition
involving incomplete septation and the presence of an actual hole between the atria, may have relatively serious consequences.
Term
Patent foramen ovale (PFO)
Definition
An opening between the two atria during fetal life.However, it is usually still functionally closed by a flap.
Term
cor pulmonale
Definition
right ventricular failure as a consequence of lung disease
Term
Endocardial cushion defect
Definition
is strongly associated with Down syndrome and may involve a variety of defects of the septa and valves.
Term
Tetralogy of Fallot
Definition
The truncus arteriosus becomes divided, but the septation is off-center so structures don't join up to the heart where they should. Basically, the pulmonary artery is too small, and the aorta is too big.
Term
Pulmonic valve stenosis
Definition
the pulmonary valve and artery are narrowed and do not allow sufficient blood flow to the lungs.
Term
Over-riding aorta
Definition
the too-big aorta connects to or "over-rides" both the right and left ventricles, and so receives blood from both. This means that unoxygenated blood from the right ventricle is going out to the body.
Term
Right ventricular hypertrophy
Definition
a consequence of the right ventricle trying to push enough blood through the narrowed pulmonary artery, compensate for the VSD, and cope with the higher than normal pressure of the left ventricle.
Term
Four anomalies that constitute Tetraology of Fallot are?
Definition
Pulmonic valve stenosis, Over-riding aorta,Ventricular septal defect and Right ventricular hypertrophy
Term
Transposition of the great arteries (TGA):
Definition
, a spiraling or helical septum forms down the length of the truncus arteriosus to divide it into the aorta and the pulmonary artery. If the septum does not spiral properly, these vessels end up attached to the heart in a reversed manner
Term
[image]
Definition
Truncus Arteriosus
Term
Patent ductus arteriosus
Definition
The ductus arteriosus is a short vessel that connects the aorta to the pulmonary artery during fetal life to allow blood to bypass the lungs. This structure normally closes after birth, but it may remain open. This condition does not lead to cyanosis, because pressure in the aorta is higher than pressure in the pulmonary artery.
Term
[image]
Definition
Patent Ductus Arteriosus
Term
Coarctation of the aorta
Definition
refers to a narrowing or stenosis of the aorta. It usually lies beyond where the arteries to the head and arms branch off, so a diagnostic sign is high blood pressure in the upper extremities and low blood pressure in the lower extremities.
Term
Atherosclerosis
Definition
lipid scarring. arises from a complex interplay between endothelial cells, macrophages, platelets, and smooth muscle cells.
Term
foam cells
Definition
which are macrophages that have become filled with large amounts of lipids).
Term
hardening of the arteries
Definition
calcification of the atherosclerotic lesions.
Term
angina pectoris
Definition
chest pain that is felt upon exertion or stress and is relieved by rest or nitroglycerin.
Term
MB form of creatine phosphokinase (CK-MB)
Definition
Enzymes that are released from the damaged cardiac muscle cells into the blood can also be used to diagnose an MI. This one is very specific for cardiac muscle cells. Rises and falls quickly.
Term
troponin
Definition
Use to diagnosis an MI. Its a cytoskeletal protein released from dead cardiac muscle cells. Rises quickly and stays elevated
Term
subendocardial infarct
Definition
An MI that involves just the inner wall of the heart
Term
transmural infarct
Definition
An MI that involves the full thickness of the heart muscle
Term
One intervention becoming widely used for MI's
Definition
anti-thrombolytic agents that dissolve clots (e.g., streptokinase or tPA [tissue plasminogen activator]
Term
myocardial stunning
Definition
lack of full function several days after blood flow has been restored to damaged myocardial cells.
Term
Chronic ischemic heart disease (also called ischemic cardiomyopathy)
Definition
can occur when a patient’s remaining heart muscle is unable to compensate for what was lost to known myocardial infarction(s).
Term
Complications of myocardial infarcts include:
Definition
Mural thrombi,Scarring and loss of function with compensatory hypertrophy of undamaged parts of the heart, Shock, Congestive heart failure, Damage to papillary muscles supporting heart, Formation of aneurysms, Ventricular rupture, Tamponade, Acquired VSD
Arrhythmia, Pericarditis
Term
CABG
Definition
coronary artery bypass graft
Term
LIMA
Definition
left internal mammary artery
Term
percutaneous transluminal coronary angioplasty
Definition
PTCA, a catheter is threaded into the artery, and a balloon on its tip is inflated to literally squash the atheroma
Term
Senile calcific aortic stenosis
Definition
a disease of the aortic valve that is most common in elderly people. It is due to wear and tear on the valve. The valve becomes calcified and stiff, so it doesn't move well.
Term
Fun Fact
Definition
aortic valve problems are more common in men, mitral valve problems in women.
Term
Bicuspid aortic valve
Definition
One in a hundred people is born with an aortic valve that has only two leaflets, rather than the usual three; indeed, this is the most common cardiovascular abnormality.
Term
Marfan's syndrome
Definition
a hereditary disease marked by abnormal, weakened connective tissue due to mutations in the fibrillin gene.
Term
Billowing
Definition
valve extends backwards like a parachute, but there is no leakage; may hear a mid-systolic click, but no murmur
Term
Prolapse
Definition
billowing along with leakage (regurgitation); may hear a murmur or mid-systolic click
Term
Floppy and flail
Definition
chordae tendineae are ruptured; must be treated surgically.
Term
Scarlet fever
Definition
caused by a toxin released from strep bacteria that are infected with a bacterial virus (bacteriophage).
Term
Rheumatic fever
Definition
caused by Group A beta-hemolytic strains of strep.
Term
Endocarditis
Definition
infection of the heart valves and may be bacterial or fungal
Term
The most frequent risk factor for endocarditis?
Definition
mitral valve prolapse
Term
nonbacterial thrombotic endocarditis (NBTE
Definition
Damaged heart valves may first be covered with a deposit of platelets,
Term
Duke criteria
Definition
Infective endocarditis is diagnosed by a number of pathologic and clinical criteria
Term
Jones criteria
Definition
Rheumatic fever itself is diagnosed by
Term
Concentric hypertrophy
Definition
the whole ventricle wall becomes evenly thickened in response to a pressure overload (e.g., systemic hypertension, aortic stenosis).
Term
Eccentric hypertrophy
Definition
The wall is of normal thickness, but the chamber is enlarged due to a volume overload (e.g., a leaky valve as in aortic regurgitation).
Term
Compensatory hypertrophy
Definition
Part of the muscle wall becomes hypertrophied to try to compensate for an area that is damaged, for example due to an infarct.
Term
Cardiomyopathy
Definition
conditions in which the primary problem is in the heart muscle (myocardium) itself.
Term
Dilated cardiomyopathy
Definition
All four chambers of the heart become enlarged, weak, and floppy, although it is usually the ventricles that are most affected. Often, the cause is idiopathic (unknown). Alcohol can directly damage the heart muscle and may lead to this condition, but not all alcoholics develop it.
Term
causes of myocarditis
Definition
Coxsackie B virus, echovirus, AIDS, Bacterial: Lyme disease(Borrelia burgdorferi) diptheria,Parasitic: Trypansoma cruzi(cause of Chagas disease), Toxoplasma gondii(problem with immunocompromised)Immune-mediated: rheumatic fever, SLE.
Term
Hypertrophic cardiomyopathy HCM AKA idiopathic hypertrophic subaortic stenosis (IHSS)
Definition
The heart becomes overly thick and muscular; it overcontracts and has trouble relaxing.
Term
Restrictive cardiomyopathy
Definition
The heart is rigid and cannot expand (i.e., diastole is impaired).
Term
amyloidosis
Definition
a condition in which certain fibrous proteins deposit abnormally in tissues
Term
Endomyocardial fibrosis
Definition
a restrictive cardiomyopathy of unknown cause. It is a disease principally of young adults and children in Africa and other tropical areas.
Term
arrhythmogenic right ventricular cardiomyopathy
Definition
there is fatty replacement of parts of the heart muscle, as well as fibrosis of the ventricular wall. Heart failure or arrhythmias may result, and there is risk of sudden death
Term
takotsubo cardiomyopathy
Definition
there is a bulging of the apex and contraction of the base of the ventricles.
Term
cardiac myxoma
Definition
Sometimes a benign tumor that usually forms in the left atrium
Term
rhabdomyoma
Definition
Sometimes this benign tumor develpoes in the hearts of children.
Term
papillary fibroelastomas
Definition
benign growths usually located on the valves
Term
Cardiac tamponade
Definition
may occur when fluid fills the space between the pericardium and the heart rapidly (e.g., blood from a stab wound or from a rupture following an MI). The heart may as well be encased in cement, as it can no longer expand after contracting.
Term
mycotic aneurysms
Definition
Aneurysms can also occur as a result of infection.
Term
ANCA
Definition
anti-neutrophil cytoplasmic antibodies
Term
Wegener's granulomatosis
Definition
A disease associated with ANCA which affects small vessels in the lung and kidney
Term
Takayasu's arteritis
Definition
particularly affects the aorta and is most common in women.
Term
Polyarteritis nodosa (PAN)
Definition
affects medium-sized to small arteries in many organs (but typically spares the lung).
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