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Cardiology
Cardiology COMLEX 2
75
Medical
Graduate
05/02/2015

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Term
Windkessel effect
Definition
coronary arteries fill in diastole and systemic arteries fill in systole
Term
MAP
Definition
= CO x TPR = diastolic + 1/3 PP = 2/3 diastolic + 1/3 systolic
Term
PP
Definition
systolic - diastolic
Term
Fick's principle
Definition
CO = SV x HR = (rate O2 used / arterial-venous O2)
Term
Effect of exercise
Definition
brain increases SV before starting, increased HR maintains increased CO
Term
archys cinnilus
Definition
cholesterol in cornea, seen in hyperlipidemia
Term
what is homocysteine a marker for
Definition
high in hyperlipidemia, increases risk of CAD, lower it with folic acid, B6, or B12 but does not decrease CAD risk so just marker
Term
when do you start hyperlipidemia meds
Definition
>160 everyone
>130 if CAD >2 risk factors
>100 if CAD, DM, PVD, AAA
Term
when do you start hyperlipidemia lifestyle modifications
Definition
>160 everyone
>130 if any CAD risk factors or comorbidities
Term
why do we lower TG, what med
Definition
causes acute pancreatitis, fibrates, nicotonic acid, fish oil, statins
Term
best way to increase HDL
Definition
exercise
Term
risk factors for CAD
Definition
smoking
HTN
HDL <35 (minus point if >60)
female >45yo or male >55yo
Male
MI/sudden death in familial male <55 or female <65yo
Term
treatment for athlerosclerosis
Definition
reduce risk factors
statins - reduce inflammation and LDL
Term
when is a cardiac stress test done
Definition
when they reach 85% of 220-age, chest pain, arrhythmia, ST changes on EKG
Term
treatment of stable angina
Definition
aspirin, BB, nitrates PRN
risk factor modification (exercise)
Term
Treatment of acute myocardial event (unstable, NSTEMI, STEMI)
Definition
MONA plus 5: morphine, O2, nitro, aspirin, statin, BB, copidogrel, heparin, maintain Mg/K
NEVER GIVE NITRO TO INFERIOR MI
thrombolytic if STEMI <12h
Term
diagnosis of varient angina
Definition
st elevation, transmural, without blockage on angio. IV ergonovine to provoke CP on angio is definitive
Term
leads and vessel for inferior, lateral, septal, anterior, and posterior MI
Definition
inferior: posterior descending of right main (II, III, AVF)

lateral: LAD or circumflux (V5, V6, I, AVL)

septal: branch of LAD (V1-3)

anteiror: LAD main (V2-4)

posterior: ST depression in V1-2
Term
myoglobin, CKMB, troponin, LDH onset, peak, duration
Definition
myoglobin: onset 1h

ckmb: onset 406h, peak 24h, duration 3d

troponin: onswt 4-6h, peak 24-48h, duration 10d

LDH: peak 48-72h, duration 10d
Term
drugs that decrease mortality post MI
Definition
BB, statin, ACEI
Term
dressler syndrome symptoms and tx
Definition
fevere, malaise, pericarditis, leukocytosis, pleuritic pain, increased ESR, 2-4wk post MI

DOC colchicine, alt steroids
Term
signs of burgda syndrome
Definition
young man, laos, thiland, ST elevations V1-3, RBBB, possible terminal S waves in lateral leads
Risk of sudden death
Term
causes of kearly B lines
Definition
LV failure
MV stenosis
lymphangitis caranomatosis
lymphatic obstruction
asbestos
sarcoidosis
Term
CHF NYHA and treatment
Definition
1) symptoms with vigorous activity: diuretic PRN, ACEI
2) symptoms with moderate activity: add BB
3) symptoms with daily activity: add spironolactone
4) symptoms at rest: at digitalis short term
Term
treat acute CHF exacerbation
Definition
nitrates remove pulmonary blood
oxygen
loops
inotropes (dobutamine)
position with legs off bed
Term
chagas signs
Definition
megaesophagus, enlarged salivary glands, romana sign (swollen eye on side of infection), dilated cardiomyopathy
Term
dilated cardiomyopathy signs and treatment
Definition
S3, balloon heart, murmurs, fatigue, dyspnea
diuretics, ACEI
Term
hypertrophic cardiomyopathy signs and treatment
Definition
SOB, CP, syncope, sudden death young athlete
S4, boot heart
bisferous pulse, systolic ejection murmur worse with valsalva

TX: BB, myomectomy if severe
Term
restrictive cardiomyopathy signs
Definition
ascites, JVD, SOB,
Term
myocarditis signs
Definition
CP, dyspnea, S3, S4, diastolic murmur, friction rub, ST/T elevations, cardiomeagly
Term
acute pericarditis signs and treatment
Definition
pleuritic CP, plusus paradoxus, pericardial riction rub, diffuse ST elevations, globular canteen heart

TX: NSAIDs for symptoms self limited
Term
constrictive pericarditis signs and treatment
Definition
kussmauls sign (JVD increases with inspiration), edema, ascites, dyspnea, pericardial thickening, square root sign equal diastolic pressures in all chambers

tx: NSAIDs, cholchine, steroids, pericardial excision
Term
pericardial effusion signs and treatment
Definition
low QRS voltage, electrical alterans, muffled heart sounds, water bottle heart, soft PMI

pericardiocentesis if risk of tamponade
Term
cardiac tamponade signs and treatment
Definition
beck's triad (JVD, muffled heart sounds, hypotension), pulsus paradoxus, electrical alterans, diffuse low voltage

tx: pericardiocentesis, if hemorrhagic surgical repair
Term
aortic regurgitation: increase, decrease, timing, sound, cause, signs
Definition
increase: expiration, handgrip
decrease: valsalva, inspiration
timing: early diastolic
sound: beat beat blow
cause: endocarditis, rheumatic, HTN, CT disease, aortic dissection (syphilis)
sx: SOB, palpitations, worse lying down, de musst, wide PP, quinke
tx: if acute emergent valve replacement, if chronic meds until LV dilation then replace
Term
pulmonic regurgitation: increase, decrease, timing, sound
Definition
increase: inspiration
decrease: valsalva, expiration
timing: early diastolic
sound: beat beat blow
Term
mitral stenosis: increase, decrease, timing, sound, cause, signs
Definition
increase: expiration, lateral decubitus, valsalva
decrease: inspiration, squat
timing: late diastolic
sound: opening snap
cause: rheumatic
signs: CP, SOB, HSM, edema, AFib, hemoptysis, kearly B lines
Term
aortic stenosis: increase, decrease, timing, sound, cause, signs, treatment
Definition
increase: expiration
decrease: valsalva, inspiration
timing: systolic ejection
sound: beat and blow at same time, ejection click
cause: congenital bicuspid, calcification, syphilis, rheumatic
sx: CP, angina, dyspnea, CHF, parvus, tardus, precordal thrill
tx: replace when >50mmHg or symptomatic
Term
pulmonic stenosis: increase, decrease, timing, sound
Definition
increase: inspiration
decrease: valsalva, expiration
timing: systolic ejection
sound: beat and blow at same time, ejection click
Term
mitral regurgitation: increase, decrease, timing, sound, cause, signs
Definition
increase: expiration, lateral decubitus, squat
decrease: inspiration, valsalva
timing: holosystolic
sound: long blow overlapping beats
cause: endocarditis, papillary rupture, MVP, marfans, rheumatic
sx: CP, SOB, palpitations, pulmonary edema, radiation to axilla and back, lateral PMI
Term
tricuspid regurgitation: increase, decrease, timing, sound, cause, treatment
Definition
increase: inspiration
decrease: valsalva, expiration
timing: holosystolic
sound: long blow overlapping beats
cause: LV failure, inferior MI, endocarditis, rheumatic, cor pulmonale
sx: asymptomatic until R heart failure, AFib
tx: replacement if no pulmonary HTN
Term
mitral valve prolapse: increase, decrease, timing, sound, cause, symptoms, treatment
Definition
increase: expiration, lateral decubitus, valsalva
decrease: inspiration, squat
timing: late systolic
sound: click
cause: CT disease, thrombi, ruptured papillary, endocarditis
sx: palpitations, CP, TIA, endocarditis
tx: BB for CP
Term
benign murmurs
Definition
split S1
split S2 on inspiration
S3 if <40 yo
early quiet systolic murmur
Term
who gets prophylactic antibiotics before dental or other procedures
Definition
prosthetic valve or any prosthetic in heart
previous endocarditis
unrepaired congenital defect
cardiac transplant with valvuloplasty

(1-2g amoxicillin 30-60 min before procedure)
Term
treatment of AAA
Definition
<5cm and asymptomatic: periodic imaging, risk factor reduction
>5cm or symptomatic or >0.5cm increase in 6mo: endovascular graft placement
Term
interpertation of ABI
Definition
normal 0.9-1
>1.3 non-compressible vessels, calcification in severe disease
<0.7 intermittent claudication
<0.3 rest pain
Term
signs of cholesterol emboli
Definition
black toes, renal insufficiency, abdominal bleeding and pain, CVA, fever, ARDS, livdeo reticularis, eosinophilia
Term
superificial thrombophlebitis signs and treatment
Definition
pain, tenderness, induration, erythema, tender palpable cord

localized: aspirin for analgesia, continue activity and recheck in 7-10d

control symptoms: bed rest, elevation, hot compresses, ambulation, elastic stockings

if septic, infected, or >5cm: anticoagulate and if infected give IV antibiotics
Term
most effective way to reduce blood pressure
Definition
weight loss
Term
when do we start blood pressure emds
Definition
3 readings at least 2wks apart of >140/90
if has DM, kidney disease, end organ damage, or CV disease start at >130/80

if >60yo can go up to 150/90
Term
definition and treatment of hypertensive urgency
Definition
BP >180/120 without symptoms
lower BP over 24h with oral meds
Term
definition and treatment of hypertensive emergency
Definition
BP >180/130 with evidence of end organ damage
reduce diastolic to 100 or 25% of presenting diastolic (which ever is less) with IV anti-HTN over 2h
begin maintenance BB
Term
cardiogenic shock: TPR, MAP, HR, CO, PWCP, skin, JVD, TX
Definition
TPR up
MAP down
HR up
CO down
PCWP up
skin cool
JVD up
NO FLUIDS, dopamine, dobutamine, nitro
Term
hypovolemic shock: TPR, MAP, HR, CO, PWCP, skin, JVD, TX
Definition
TPR up
MAP down
HR up
CO down
PCWO down
skin cool
JVD down
crystalloid, fluids, RBC, monitor urine
Term
neurogenic shock: TPR, MAP, HR, CO, PWCP, skin, TX
Definition
TPR down
MAP down
HR down
CO down
PCWP unchanged
skin warm
some fluids, atropine, vasopressors, casoconstrictors, T bird
Term
septic shock: TPR, MAP, HR, CO, PWCP, skin, JVD, TX
Definition
TPR down
MAP down
HR up CO up
PCWP unchanged
skin warm
JVD down
lots of fluids, norepinepherine, antibiotics
Term
anaphylactic shock: TPR, MAP, HR, CO, PWCP, TX
Definition
TPR down
MAP down
HR up
CO up
PCWP down
fluids, epinepherine, H1/2 blockers, steroid
Term
define SIRS, sepsis, severe sepsis, septic shock
Definition
SIRS (2 minimum): temp <38/<36, HR >90, RR >20, PaCO2 <32, WBC >12/<4/>10% bands

sepsis: SIRS with source of infection

severe sepsis: sepsis with organ dysfunction, hypoperfusion, or hypotension

septic shock: severe sepsis with hypotension despite fluid recussitation
Term
fetal circulation
Definition
1) placenta > umbilical vein > ductus venosus (bypasses liver, mix point with nonO2 blood from LE) > IVC > RA

2) could go to foramen ovale and into LA/LV and to aorta or go through RV/PA and through PDA into aorta

3) oxygenates the body and returns to placenta via umbilical artery
Term
signs of vascular rigns
Definition
stridor, crowing respiration, hyperextended neck, dysphagia, bronchoscopy showing tracheal compression, barium swallow showing compression from abnormal vessels
Term
signs of williams syndrome
Definition
elfin facies, MR, hypercalcemia, supravalvular aortic stenosis (dyphragmatic hour glass narrowing)
Term
associations with aortic coarctation
Definition
turner syndrome
bicuspid aorta
Term
figure 3 sign
Definition
aortic coarctation
Term
associations with ASD
Definition
ostium secondum (80%): none, #1 defect in adults
ostium primum: down syndrome
deep sea diving and high altutide sickness
Term
associations with VSD
Definition
#1 congenital heart disease
fetal alcohol syndrome **
downs
cri du chat
trisomies
Term
when do we fix a septal defect
Definition
1.5:1 pulmonary to systemic or symptomatic
Term
causes of PDA
Definition
maternal rubella, high altutide, premature birth, maternal PGE, female baby
Term
signs of tertalogy of fallot
Definition
tet spells, cyanosis, clubbing, crescendo decrescendo murmur
boot heart
sudden cardiac death
Term
association with truncus arteriosis
Definition
maternal diabetes
Term
association with transposition of the great vessels
Definition
apert syndrome, downs, cri du chat, trisomies
Term
signs of transposition of the great vessels
Definition
cyanosis, loud S2, CXR with egg on string appearance, pulmonary markings, narrow heart base
Term
gold standard for diagnosis of thoracic aortic aneurysm
Definition
spiral CT
Term
gold standard for diagnosis of thoracic aortic aneurysm
Definition
CT of chest with contrast
Term
gold standard for diagnosis of AAA
Definition
ultrasound
Term
treatment of thoracic aortic aneurysm
Definition
>5cm or symptomatic: surgery
<5cm: CT in 6mo, in no change CT again in 12mo
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