Term
Focal necrotizing vasculitis
Necrotizing GRANULOMAS in the upper lung airway
necrotizing glomerulonephritis |
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Definition
Wegener's granulomatosis
c-ANCA is a strong marker
Tx: Cyclophosphamide, steroids |
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Term
| Granulomatous vasculitis with eosinophilia. Most commonly asthma, sinusitis and peripheral neuropathy (foot drop) |
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Definition
Churg Strauss Syndrome
p-ANCA |
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Term
Port-wine stain on face
Ipsilateral leptomeningeal angiomatosis (intracerebral AVM)
Seizures, early onset glaucoma |
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Definition
Sturge Weber Disease
affects small vessels |
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Term
| Most common form of childhood systemic vasculitis. Usually follows URIs and has IgA immune complexes |
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Definition
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Term
| Thrombosing vasculitis of small and medial peripheral arteries and veins. Seen in heavy smokers |
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Definition
Buerger Disease
Tx: Stop smoking |
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Term
| Acute self-limiting vasculitis seen in infants/children. Seen with asian ethnicity. |
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Definition
Kawasaki Disease
Tx: IVIg, aspirin (the only time you can give aspirin to a kid) |
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Term
Immune complex mediated vasculitis with fibrinoid necrosis
Associated with Hepatitis B |
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Definition
Polyarteritis Nodosa
Typically involves renal and visceral vessel, not pulmonary arteries
Tx: Steroids, cyclophosphamide |
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Term
"Pulseless disease"
Granulomatous thickening of aortic arch and/or proximal great vessels
Increased ESR |
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Definition
Takayasu Arteritis
Primarily affects Asian females
Tx: Prednisone |
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Term
| Most common vasculitis affecting branches of carotid arteries. Usually affects elderly females |
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Definition
Temporal Arteritis aka Giant Cell arteritis
Leads to irreversible blindness if left untreated |
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Term
| Symptoms of hemoptysis, hematuria, and perforation of the nasal septum. Can also have chronic sinusitis, otitis media, mastoiditis, cough, dyspnea |
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Definition
Wegener's granulomatosis
c-ANCA
Tx: Cyclophosphamide, steroids |
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Term
Skin rash on buttocks and legs (PALPABLE PURPURA)
Arthralgia
Intestinal hemorrhage and pain |
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Definition
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Term
Known as thromboangiitis obliterans
Intermittent claudication, superficial nodular phlebitis
May lead to gangrene and autoamputation of digits/limbs |
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Definition
Buerger's disease
Commonly presents in heavy smokers and 40 year old men |
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Term
Fever, conjunctivitis, strawberry tongue, lymphadenitis, desquamative skin rash.
Risk for developing CORONARY ANEURYSM |
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Definition
Kawasaki Disease
Usually presents with fever persisting longer than 7 days |
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Term
Fever, arthritis, neat sweats, myalgia, skin nodules, ocular distubances, weak pulses in upper extremity
Weak muscles in upper extremities |
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Definition
Takayasu Arteritis
Tx: Prednisone |
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Term
Headaches
Jaw claudication
Impaired vision |
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Definition
Temporal arteritis (giant cell arteritis)
Leads to irreversible blindness if left untreated
Tx: High dose steroids |
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Term
| Benign capillary hemangioma of infancy. Initially grows with child, then spontaneously regresses |
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Definition
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Term
| Benign capillary hemangioma of elderly. Does not regress. Increases with age |
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Definition
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Term
| Polypoid capillary hemangioma that can ulcerate and bleed. Assocated with trauma and pregnancy |
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Definition
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Term
| Cavernous lymphangioma of neck. Assocated with Turner's syndrome |
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Definition
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Term
| Benign, painful red-blue tumor under fingernails |
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Definition
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Term
Benign capillary skin papules found in AIDS patients. Caused by bartonella helenslae infections.
Frequently mistaken for Kaposi Sarcoma |
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Definition
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Term
| Highly lethal malignancy of the liver. Associated with vinyl chloride, arsenic and ThO2 (thorotrast) |
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Definition
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Term
Lymphatic malignancy associated with persistant lymphedema
Common in woman post-mastectomy |
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Definition
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Term
| Endothelial malignanc of skin associated with HHV-8 and HIV |
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Definition
Kaposi sarcoma
Frequently mistaken for bacillary angiomatosis |
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Term
| Cavernous hemangiomas in skin, mucosa, organs; bilateral renal cell carcinoma, hemangioblastoma in retina, brain stem, cerebellum; pheochromocytomas |
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Definition
Von Hippel Lindau
Autosomal dominant, mutated tumor suppressor VHL on chromosome 3 |
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