Term
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Definition
Alkylating agent
Action: Binds DNA, quick acting
AE: acute nausea, vomiting; delayed: decreased blood counts. 3-6 week recovery |
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Term
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Definition
alkylating agent.
Action: crosslinks DNA blocking DNA synth
AE: Acute: nauseas and renal toxicity(dose limiting) |
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Term
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Definition
Antimetabolite
Action: cytosine analogue chain terminator
AE: bone marrow GI |
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Term
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Definition
Antitumor antibiotics IV
Action: binds DNA generates radicals
AE: hypersensitivity, cutaneous rxns, pulmonary toxicity, fibrosis. |
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Term
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Definition
Antimetabolite
Action: inhibit thymidylate synthase
AE: bone marrow GI |
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Term
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Definition
Antimetabolite
Action: cytosine analogue chain terminator ploymerase inhibitor
AE: bone marrow GI |
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Term
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Definition
Alkylating agent
Action: binds DNA, activated by host
AE: Acute: nausea and vomiting Delayed: bone marrow depletion, alopaciea; Signature: sterile hemmorrhagic cystisis caused by Acrolein a metabolite. |
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Term
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Definition
Antimetabolite
Action: Oral blocks dna and RNA inhibit AMP and GMP synth.
AE: well tolerated up to high doses |
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Term
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Definition
Antimetabolite
Action: Oral incorporates into RNA/DNA.
AE: well tolerated up to high doses |
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Term
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Definition
Antitumor antibiotics IV
Actions: intercalate DNA blodk Topo II, inhibit DNA/RNA synth cause strand breaks, free radicals
AE: Bone marrow suppression, GI distress, alopecia, CARDITOXICITY |
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Term
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Definition
Anti tumor antibiotics IV
Actions: intercalate DNA blodk Topo II, inhibit DNA/RNA synth cause strand breaks, free radicals
AE: Bone marrow suppression, GI distress, alopecia, CARDITOXICITY |
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Term
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Definition
Hormonal Agent Oral
Action: Azole treatment of ER+ primary and metastatic cancers
AE: acute mild nausea, headache
delayed: hot flashes, fatigue |
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Term
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Definition
Hormonal agent ORal
Action: with radiation against prostate cancer. ligand fro AR
AE: mild: nausea, hot flushes, transient hepatic effects |
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Term
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Definition
Hormonal agent Oral
Action: Suppress immune cell proliferation
AE: fliud retention, immunosuppression, diabetes |
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Term
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Definition
Hormonal Agent oral
Action: Azole treatment of ER+ primary and metastatic cancers
AE: acute mild nausea, headache
delayed: hot flashes, fatigue |
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Term
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Definition
hormonal agent Oral
Action: Suppress immune cell proliferation
AE: fliud retention, immunosuppression, diabetes |
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Term
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Definition
Hormonal agent Oral
Action:ER antagonist in breast primary and metastatic ER+ breast cancer
may be activated by CYP2D6
AE: nausea, hot flushes, vagianl bleeding only use for 5 years |
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Term
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Definition
MT poisonsIV with detergent
Action: stabalizes MT
AE: acute: hypersensitivity and nausea
delayed bone marrow suppression, neuropathy |
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Term
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Definition
MT poisons IV with detergent
Action: stabalizes MT
AE: acute: hypersensitivity and nausea
delayed bone marrow suppression, neuropathy |
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Term
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Definition
MT poisons IV
Action: inhibits tubulin polymerization
AE: nausea vomiting, alopecia, bone marrow depression |
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Term
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Definition
MT poisons IV
Action: inhibits tubulin polymerization
AE: peripheral neuropathy, minor Bone marrow effect |
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Term
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Definition
Biological Parenteral
Action: alters gene expression increases immune response. hematological malignancies, metastatic melanoma, renal cell carcinoma.
AE: fever, chills, anorexia and weakness |
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Term
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Definition
Biological IV
Action: antibody to HER2neu/ErbB-2 oncogene product
AE: infusion rxns, hypersensitivity, cardiomyopathy
Will not cross BBB bad for brain metastasis |
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Term
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Definition
Topoisomerase inhibitors Oral/IV
Action: topoisomerase II, ds breaks, DNA degredation
AE: nausea vomiting, alopecia, bone marrow suppression |
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Term
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Definition
Topoisomerase inhibitor IV oral
Action: Topoisomerase I
AE: acute: nausea, vomiting, diarrhea
delayed: bone marrow suppression, nausea, dose-limiting diarrhea
UGT1A1 deficiencies make Gi stuff real bad. |
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Term
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Definition
Tyrosine Kinase inhibitor Oral
Action: Inhibits EGF-R tyrosine Kinase
a. For small cell lung cancer
AE: Fever, dyspnea |
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Term
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Definition
Tyrosine Kinase inhibitor Oral
Action: Inhibits BCR-Abl and other tyr kinase. CML and kit kinase in GIST.
AE: myelo suppressive edema and fluid retention, hepatotoxicity
NOT a CURE |
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Term
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Definition
Ancillary drugs
used to treat anemia |
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Term
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Definition
ancillary drug
used to treat anemia |
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Term
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Definition
ancillary drug
Used to scavenge Acrolein from Cyclophosphophamide |
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Term
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Definition
Ancillary drug
5-HT used to treat nausea |
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Term
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Definition
Antimetablolite
Action: DHFR inhibitor prevents base synthesis.
AE: bone marrow and GI, hepatotoxicity |
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