Term
| Anti-Metabolites target where? |
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Definition
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Term
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Definition
Anti-Folate
- Methotrexate
Pyramidine Analog
- 5-flurouracil
- Cytarabine
Purine Analog
- Mercaptopurine |
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Term
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Definition
Anti-Folate
MOA = inhibit DHF reductase
causes...
- N+V, Mucositis, Diarrhea, BMS
NSAIDS + Penacillins increase toxicity by decreasing renal excretion
Leucovorin Rescue can decrease side effects |
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Term
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Definition
Pyramidine Analog
MOA = inhibit thymidylate synthase
causes...
- N+V, Mucositis, Diarrhea, BMS
- Hand-foot syndrome
- give B6
- Neurotoxicity
- give B6 |
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Term
|
Definition
Purine Analog
MOA = inhibit PRPP Amidotransferase
causes...
- N+V, Mucositis, Diarrhea, BMS
- Hyperpigmentation of skin
- Immunosuppresion |
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Term
|
Definition
Pyramidine Analog
MOA = inhibit DNA polymerase after phos. + incorporation into DNA
causes...
- N+V, Mucositis, Diarrhea, BMS
- Hepatotoxicity + Neurotoxicity (cerabellar ataxia) |
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Term
| Alkylating Agents target where? |
|
Definition
Non-cell cycle specific
MOA = Cross-linking and intrastrand linking |
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Term
|
Definition
Nitrogen Mustards
- Cyclophosphamide
- Ifosfamide
Platinum Analog
- Cisplatin
- Oxyplatin
Methylhydrazines
- Procarbazine
Nitrosourea
- Carmustine
- Loumustine |
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Term
|
Definition
Nitrogen Mustards
causes...
- BMS, N+V
- Hemorrhagic Cystitis
MESNA is protective |
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Term
|
Definition
Nitrogen Mustards
causes...
- BMS, N+V
- Hemorrhagic Cystitis
MESNA is protective |
|
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Term
|
Definition
Platinum Analog
causes...
- Nephrotoxicity
- Give Amifostine
- dont give Ampheteracin B
- Severe N+V
- Give Ondansteron
- Ototoxicity
- dont give AG or loops
- BMS + Peripheral Neuropathy
- HS to platinum |
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Term
|
Definition
Platinum Analog
causes...
- No Nephrotoxicity or Ototoxicity like Cisplatin
- Severe N+V
- Give Ondansteron
- BMS + Peripheral Neuropathy
- HS to platinum |
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Term
|
Definition
Methyl Hydrazine
causes...
- BMS
- Disulfaram Effect (avoid alcohol)
MAO inhibitor
- cation w/ Tyramin foods, TCA's |
|
|
Term
|
Definition
Nitrosourea
causes...
- BMS, N+V
- interstial Pneumonitis
CROSS BBB |
|
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Term
|
Definition
Nitrosourea
causes...
- BMS, N+V
- interstial Pneumonitis
CROSS BBB |
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Term
|
Definition
Vinca Alkyloids
- Vinblastine
- Vincristine
Taxanes
- Paclitaxel
Camptothecin Analogs
- Irinotecan
- Toatecan
Epipodophyllotoxin
- Etoposide |
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Term
| Vinca Alkyloids target where? |
|
Definition
|
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Term
|
Definition
Vinca Alkyloid
MOA = inhibit Microtubule polymerization
- Arrest in Metaphase
causes...
- BMS
- Peripheral Neuropathy
- Constipation + SIADH |
|
|
Term
|
Definition
Vinca Alkyloid
MOA = inhibit Microtubule polymerization
- Arrest in Metaphase
causes...
- No BMS
- Peripheral Neuropathy
- Constipation + SIADH |
|
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Term
|
Definition
Taxane
MOA = inhibit Microtubule depolymerization
- Arrest in Prophase
causes...
- BMS, N+V, Diarrhea
- Peripheral Neuropathy
- HS Rxn |
|
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Term
|
Definition
Camptothecin Analog
MOA = inhibit Topoisomerase 1
causes...
- BMS, N+V |
|
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Term
|
Definition
Camptothecin Analog
MOA = inhibit Topoisomerase 1
causes...
- BMS, N+V |
|
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Term
|
Definition
Camptothecin Analog
MOA = inhibit Topoisomerase 2
causes...
- BMS, N+V
- HS Rxn
- Hypotension |
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|
Term
| List Anti-tumor Antibiotics |
|
Definition
Actinomycin D (aka Dactinomycin)
Bleomycin
Daunorubicin
Doxorubicin |
|
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Term
|
Definition
AKA Dactinomycin
MOA = inhibit RNA polymerase
causes...
- BMS, N+V, Mucosititus, Diarrhea
- Hepatotoxicity
- Hyperpigmentation of Skin |
|
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Term
|
Definition
G2 phase specific
MOA = Binds to iron to form free radicals
causes...
- Pulmonary Fibrosis!!!!
- skin pigmentation |
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Term
|
Definition
MOA = inhibits Topoisomerase 2
causes...
- BMS, N+V, mucositis, Diarrhea
- Red-orange urine
- Cardiomyopathy + CHF |
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Term
|
Definition
MOA = inhibits Topoisomerase 2
causes...
- BMS, N+V, mucositis, Diarrhea
- Red-orange urine
- Cardiomyopathy + CHF |
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Term
| List Monoclonal Antibodies |
|
Definition
| Rituximab and Trastuzamab |
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Term
|
Definition
CD20 (B cell)
Focused on Bone with slight aid in Breast Cancer
Good for Autoimmune Disorders + Rheumatoid Arthritis |
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Term
|
Definition
Erb B2 AKA Her2/neu
Good for Breast!!! and Gastric Cancer
(GIST Tumors) |
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Term
|
Definition
| Tyrosine Kinase Inhibitor |
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Term
|
Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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