Term
|
Definition
Alkylating agent: Nitrogen Mustard
crosslinked DNA
most reactive
unstable, given IV
N&V, bone marrow, tissue damage with extravasation |
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Term
|
Definition
Alkylating agent: Nitrogen Mustard
crosslinked DNA
oral
prodrug, converted P450
N&V, CARDIAC, BLADDER BURN, bone marrow |
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Term
|
Definition
Alkylating agent: Nitrogen Mustard
crosslinked DNA
given IV with MESNA
converted by P450
N&V, NEURO, NEPHRO, bladder burn, cardiac toxicity, bone marrow |
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Term
|
Definition
Alkylating agent: Nitrosureas
inhibits DNA, RNA, protein synthesis
lipid soluble (BBB)
IV
BONE MARROW, N&V, PULMONARY, renal |
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Term
|
Definition
Aklyating agents: alkyl sulfonates
oral
N&V, BONE MARROW, pulmonary fibrosis |
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Term
|
Definition
Platinum complexes
crosslinks with GG base pairs
IV
BOUND to plasma proteins
N&V, diarrhea, RENAL DAMAGE (reduced with hydration), OTOTOXICITY, NEUROPATHY (proprioception), bone marrow depression |
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Term
|
Definition
Platinum complexes
longer half-life than cisplatin, less effective, less toxic
IV
less neuro/oto |
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Term
|
Definition
Antimetabolite
analog of folic acid
oral, IV, IM, intrathecal
HEPATIC NECROSIS, bone marrow
Leucovorin can rescue |
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Term
|
Definition
Antimetabolite
fraudulent F-dUMP, inhibits thymidalate synthase
IV (TOXIC to GI)
Leucovorin POTENTIATES fluorouracil |
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Term
|
Definition
Anti-metabolite
prodrug of fluorouracil |
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Term
|
Definition
Antimetabolite
inhibits guanine synthesis
DNA strand breaks
TX: leukemia in children
oral, IV
metabolized in liver (TPMT, Xanthine oxidase)
bone marrow depression |
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Term
|
Definition
Antimetabolite
cytosine arabinoside
aracytidine triphosphate
inhibits DNA elongation
IV
bone marrow depression |
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Term
|
Definition
Antibiotics
topoisomerase
IV
metabolized liver
CARDIO - free radical
extravasation |
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Term
|
Definition
Antibiotic
topoisomerase
IV
CARDIO
interaction: cimetidine avoided |
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Term
|
Definition
Antibiotic
intercalates into DNA
topoisomerase
IV
does not cross BBB
severe local damage with extravasation |
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Term
|
Definition
Antibiotic
copper chelating glycopeptide - free radical damage
IV, subQ, IM
no significant bone marrow tox
degraded by hyrdolase (low in LUNGS, skin) |
|
|
Term
Vinca Alkaloids
(Vincristine
Vinblastine
Vinorelbine) |
|
Definition
bind tubulin, inhibit polymerization
IV
Vincristine: mild bone marrow, axonal=sensory
Vinorelbine: bone marrow, mild neuro
Vinblastine: more marrow, mild neuro |
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Term
|
Definition
stablizes polymerized microtubules
IV
peripheral sensory neuropathy |
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Term
|
Definition
cause DNA breaks by blocking topoisomerase
oral, IV
bone marrow depression
sensory neuropathy |
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Term
|
Definition
binds retinoid x receptor
retinoic acid syndrome: fever, dyspnea, weight gain, pulmonary infiltrates, pleural or pericardial effusions)
tx: acute promyelocytic leukemia |
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Term
|
Definition
uncouples mitochondrial oxidative phos
generates free radicals
arrhythmias
tx: relapsed acute promyelocytic leukemia |
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|
Term
exemestane
letrozole
anastrozole |
|
Definition
aromatase inhibitors
block androgen -> estrogen
musculoskeletal pain, HA, joint pain, fatigue, difficulty breathing
tx: breast cancer |
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Term
|
Definition
tyrosine kinase inhibitor
estrogen receptor
oral, metabolized liver
tx: estrogen-dependent breast cancer |
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Term
|
Definition
gleevec
bcr-abl
chronic myelogenous leukemia
metabolized cyp3a4
bcr-abl detected by FISH |
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Term
|
Definition
recognizes her2 receptors
metastatic breast cancer
toxicity: cardiomyopathy, infusion |
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Term
|
Definition
egfr or her1
tx: metastatic colorectal cancer
toxicity: severe infusion-related, acneiform rash |
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Term
|
Definition
vegf (inhibition of angiogenesis)
tx: metastatic colorectal cancer
toxicity: hypertensino, proteinuria, congestive heart failure |
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