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Cancer Biology BIO346 Ch. 7
Chapter 7
23
Biology
Undergraduate 3
05/14/2012

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Term
oncogenic virus
Definition
cancer-causing virus
Term
Epstein-Barr virus (EBV)
Definition
DNA-containing herpesvirus group. causes burkitt's lymphoma.
Term
infectious mononucleosis
Definition
EBV infection can trigger nonmalignant proliferation of lymphocytes-produces flu-like symptoms.
Term
human papillomavirus
Definition
DNA virus implicated in cancer of the uterine cervix and in anal and genital cancers.
Term
HBV
Definition
DNA virus. transmitted by bodily fluid exchange. Causes liver cancer in patients infected for years.
Term
human T-cell lymphotropic virus-I
Definition
retrovirus that causes human cancer. causes adult human t-cell lymphotropic virus-I. part of diagnostic criteria fro this type cancer.
Term
acquired immunodeficiency herpesvirus
Definition
debilitated immune system that puts increased risk for several cancer types. developed from HIV.
Term
Kaposi's sarcoma-associated herpesvirus (KSHV)
Definition
discovered in specimens of Kaposi's sarcoma tissue. sexually transmitted with causative role in Kaposi's sarcoma.
Term
Helicobacter pylori
Definition
spiral shaped bacterium. causes gastritis which leads to development of stomach ulcers.
Term
liver fluke
Definition
parasitic flatwormsacquired by eating undercooked fish. once ingested it moves from the intestineds into the bile ducts. once lodged in smaller ducts of liver inflammation is triggered. then bile duct liver.
Term
virus
Definition
tiny particle, too small to be seen with a light microscope that depends on living cells for its reproduction.
Term
episome
Definition
independently replicating molecule that persists indefinitely, independently.
Term
integrase
Definition
integrates the resulting DNA copy of the viral RNA into the host's chromosomal DNA which is then subsequently replicated along with it.
Term
retrovirus
Definition
RNA viruses that employ the reverse transcriptase pathway to integrate their genetic info into a host cell.
Term
v-src gene
Definition
viral sarcoma gene. triggers the development of cancer.
Term
SRC gene
Definition
cellular sarcoma. normal gene in human cells. not present in the Rous virus.
Term
v-Src (protein)
Definition
protein kinase that regulates the activity of targeted protein molecules by catalyzing theSrcation, these transmit signals from one molecule to another.
Term
Src kinase
Definition
normal version of the v-Src kinase produced by the Rous virus. activated when certain growth factors bond to receptors on cell surface.
Term
oncoprotein
Definition
protein whose activity contributes to the development of cancer.
Term
MYC gene
Definition
ALV inserts itself near this cellular gene. it is a proto-gene that can be converted into an oncogene.
Term
long terminal repeats (LTRs)
Definition
located at both ends of the genome of retroviruses and serve in the mechanism by which proviral DNA is inserted into the host chromosomal DNA and promote transcriptions of adjacent viral gene
Term
E6 oncoprotein
Definition
circumvents DNA damage repair by binding to the p53 protein and promoting its destruction.
Term
gene therapy
Definition
treat genetic diseases by inserting normal copies of genes into the cells of patients who have inherited defective disease-causing genes.
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