Term
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Definition
| cell type that lines the internal surface of blood and lymphatic vessels |
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Term
| vascular endothelial growth factor (VEGF) |
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Definition
| triggers angiogenesis by binding to a specific receptor protein located on surface of endothelial cells. |
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Term
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Definition
| can be activated by binding to VEGF |
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Term
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Definition
| inhibitor of angiogenesis; fragment of the protein plasminogen |
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Term
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Definition
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Term
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Definition
| direct migration and pentration of cancer cells into neighboring tissues. |
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Term
| cell-cell adhesion protein |
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Definition
| molecules that function to keep cells in place by binding interaction among them on the outside of a cell. cancer cells often have very few of these if any at all. |
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Term
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Definition
| protein-degrading enzyme. Break down structures that represent barriers to cancer cell movement. |
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Term
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Definition
| active protease form of plasminogen. It degrades componenets of the basal lamina and the extracellular matrix (good for invasion) and cleaves inactive precursors of MMPs into active enzymes. |
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Term
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Definition
| the gradual change in the properties of a tumor cell population as cells acquire more and more aberrant traits and become increasingly aggressive. |
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Term
| cytotoxic T lymphocyte (CTL) |
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Definition
| class of immune cell specialized for attacking foreign and abnormal cells. lung cancer in mice: CTLs target A9 cells instead of D122 because of MHC molecules carried by A9 cells and not D122 cells. |
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Term
| metastasis promoting gene |
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Definition
| positively acting genes that code for proteins that stimulate events associated with invasion and metastasis. |
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