Term
How are CCB classified? What CCB falls into each class? |
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Definition
• Dihydropyridines (all the -pines are -dines)** • Nifedipine (Procardia) • Amlodipine (Norvasc) • Felodipine (Plendil) • Isradapine (DynaCirc) • Nicardipine (Cardene) • Nimodipine (Nimotop) • Phenyalkylamines • Verapamil (Calan, Isoptin, Verelan, Covera HS) • Benzothiazepines • Diltiazem (Cardizem, Dilacor, Tiazac) |
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Term
| What the major clinical effects of each class? |
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Definition
Voltage gated calcium ion channels are present in the cell membranes of skeletal muscle, vascular smooth muscle, cardiac smooth muscle, glandular cells, and neurons. • There are two types of voltage-gated channels (T and L). CCB work at the L-type channel. |
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Term
what is the mechanism of action of verapimil? |
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Definition
(Verapamil) binds to the intracellular portion of the L-type channel when the channel is in the open state and physically occludes the channel. • Verapamil is selective for calcium channels in the atrioventricular node. |
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Term
| What are some common adverse reactions for Verapimil? |
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Definition
- Decreased UTERINE BLOOD FLOW
- Depressed AV Node
- Negative Chronotrope
- Negative Inotrope
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Term
| what are clinical effects of Diltiazem? |
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Definition
Blocks the calcium channels at the AV node and is a first line agent for the treatment of supraventricular tachyarrhythmias. |
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Term
What are clinical effects of Nifedipine? |
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Definition
Coronary/peripher vasdilator, decreases BP, Increases HR
Treatment of: Angina, Coronary vasospasm, and hypertensive emergency |
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Term
| Clinical uses of Nimodipine? |
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Definition
| Prevents cerebral vascular vasospasm |
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Term
| what are common drug interactions assoiated with CCBs? |
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Definition
-Anesthesia Drugs
Verapimil-May cause myocardial depression and decreased Cardiac output.
they potentiate effects of polaring/nonpolaring neuromuscular blockers |
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