Term
PMNs (Neutrophils) Extravasate... |
|
Definition
-Only in the Post-Capillary Venules!!
|
|
|
Term
PMN-ENDOTHELIAL CELL ADHESIVE INTERACTIONS |
|
Definition
Neutrophil Endothelial
L-Selectin E-Selectin
LFA-1(CD11a/CD18) ICAM-1
MAC-1(CD11b/CD18) ICAM-1
VLA-4 (α4β1) VCAM-1
|
|
|
Term
Neutrophil and Endothelial Adhesion Molecules
|
|
Definition
LEUKOCYTE ADHESION MOLECULES
Integrins
b1 Integrins: Very Late Antigen-4 (VLA-4; a4b1)
b2 Integrins: CD18 combined with either
CD11a (CD11a/CD18; αLβ2 ; LFA-1)
or CD11b (CD11b/CD18; αMβ2, MAC-1)
Selectins: L-selectin
ENDOTHELIAL CELL ADHESION MOLECULES
Immunoglobulin Supergene Family
Intercellular cell adhesion molecule-1 (ICAM-1);
Vascular CAM-1 (VCAM-1)
Selectins: E-selectin
|
|
|
Term
|
Definition
- binds to IL8 receptor
- responsible for extravasation into interstitium |
|
|
Term
T-Cell Trafficking during Immune Response
|
|
Definition
-Naive T-Cell comes from Artery
- Travels through High Endothelial Venule to Draining Lymph Node
-Receives antigen from dendrite and proliferates to effector T-Cell
-Exits Efferent Lymphatics to systemic circulation |
|
|
Term
Recirculation of Naïve T-Cells
|
|
Definition
- Naive T-Cells will recirculate through body continuously until it matures after receiving antigen |
|
|
Term
NAIVE T-Cell-HEV ADHESIVE INTERACTIONS
|
|
Definition
Naive T-Cell HEV
L-Selectin PNAd
CCR7(Chemokine Receptor) CCL21
LFA-1(CD11a/CD18) ICAM-1 |
|
|
Term
Activated/Effector T-Cell-Endothelial Cell Adhesive Interactions (in Gut)
|
|
Definition
Activated/Effector T-Cell Endothelial
PSGL-1 P-Selectin
CCR9 CCL25
LFA-1(CD11a/CD18) ICAM-1
VLA-4 VCAM-4 |
|
|
