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BYU Dr. Erickson Ch. 14
principles of Disease and Epidemiology
56
Microbiology
Undergraduate 1
10/20/2010

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Term
Pathology
Definition
study of diseases
Term
pathogenesis
Definition
manner in which a disease develops
Term
Etiology
Definition
study of the cause of a disease
Term
Infection
Definition
invasion or colonization of the body by pathogenic microorganisms
Term
Disease
Definition
state in which the body is not functioning correctly. Caused by an infection.
Term
Normal microbiota or normal flora
Definition
microorganisms that establish a more or less permanent residence in the human body.
Term
Transient microbiota
Definition
may be present for several days, weeks, months.
Term
Microbal antagonism/ competitive exclusion
Definition
normal flora prevent overgrowth of harmful microorganisms by competing for nutrients, affecting conditions such as pH levels(Candida albicans/ yeast infection), producing bacteriocin (E. coli), or filling up receptor sites(Clostridium difficile).
Term
commensalism
Definition
form of symbiosis where one benefits, one unaffected. most common relationship of normal flora to host.
Term
Mutualism
Definition
form of symbiosis where both organisms benefit
Term
parasitism
Definition
form of symbiosis in which one benefits at the expense of the other.
Term
Probiotics
Definition
live mircobial cultures applied to or ingested with the intent to exert a beneficial effect.
Term
oppurtunistic pathogens
Definition
usually don't cause disease in their normal habitat in a healthy person, but may cause disease if the host is weakened.
Term
symptoms
Definition
changes in body function that are not really measurable, such as pain and malaise.
Term
signs
Definition
measurable qualities of a disease, such as fever, lesions, swelling, and paralysis.
Term
syndrome
Definition
a specific group of signs and symptoms that always accompanies a particular disease
Term
communicable disease
Definition
a disease that spreads from one host to another directly or indirectly (chicken pox, herpes, typhoid, tuberculosis)
Term
contagious
Definition
diseases that are spread easily from one person to another. (chicken pox, measles)
Term
noncommunicable disease
Definition
disease that does not spread from one host to another (Lyme, tetanus)
Term
incidence
Definition
# of people in a population that develop a disease during a designated time period
Term
prevalence
Definition
fraction of people with a disease at any given time. Differs from incidence in that it takes into account latent and chronic infections.
Term
sporadic disease
Definition
disease that occurs occasionally (typhoid in the U.S.)
Term
endemic disease
Definition
a disease that is always present in low amounts (common cold)
Term
epidemic
Definition
many people in a given area acquire a certain disease in a relatively short time
Term
pandemic
Definition
a worldwide epidemic
Term
acute disease
Definition
disease that develops rapidly but last for a short time
Term
chronic disease
Definition
develops slowly but the disease continues to recur for long periods. (HIV, tuberculosis)
Term
subacute disease
Definition
somewhere between acute and chronic
Term
latent disease
Definition
disease where the causative agent remains inactive for long periods of time but then becomes active to produce symptoms. (shingles)
Term
herd immunity
Definition
enough of the population is immune to a disease, so the pathogen has nowhere to grow and reproduce.
Term
local infection
Definition
invading microorganisms are limited to a relatively small are of the body (boils, abscesses)
Term
systemic (generalized) infection
Definition
microorganisms spread throughout body (measles)
Term
focal infection
Definition
starts at a focal point, but then spreads (starts at a lymph node, spreads to other lymph nodes)
Term
sepsis
Definition
toxic inflammatory condiditon arising from the spread of microbes, especially bacteria or their toxins. From a focus of infection. #1 cause= lipid A (endotoxin)
Term
Septicemia
Definition
growth of microbes in blood, example of sepsis.
Term
bacteremia
Definition
presence of bacteria in blood
Term
Toximia
Definition
presence of toxins in blood (tetanus)
Term
viremia
Definition
Presence of virus in blood
Term
acute infection
Definition
an acute infection that causes the initial illness
Term
secondary infection
Definition
caused by opportunistic pathogens after the primary infection has weakened the host.
Term
subclinical (innaparent) infection
Definition
does not cause notable illness. you can carry the pathogen without experiencing the symptoms (hepatitis A)
Term
predisposing factors
Definition
make the body more susceptible to disease (gender, season, sickle cells)
Term
Development of Disease
Definition
1 incubation period- no signs or symptoms
2 prodromal period- short, early symptoms
3 illness- most severe symptoms and signs
4 decline- symptoms subside
5 convalescence- regain strength
Term
reservoir of infection
Definition
provides a pathogen with adequate conditions for survival and multiplication and opportunity for transmission.
Term
Human reserviors
Definition
carriers. can display symptoms or not.
Term
animal reservoirs
Definition
diseases transmitted animal ---> human are called zoonoses. (rabies, lyme)
Term
nonliving reservoirs
Definition
soil (fungi, C. botulinum, C. tetani), water( Vibrio cholerae, typhoid)
Term
indirect contact transmission
Definition
infection involving a fomite, or a nonliving object such as a cup, door handle, keyboard, etc.
Term
droplet transmission
Definition
mucous droplets from sneezing, coughing, laughing. airborne.
Term
Mechanical transmission
Definition
passive transport of pathogens from a vector's feet or mouth
Term
Mechanical transmission
Definition
passive transport of pathogens from a vector's feet or mouth (housefly)
Term
biological transmission
Definition
more complex than mechanical, involves the pathogen adapting to the vector before transmitting to host (flea with yesenia pestis)
Term
compromised host
Definition
one whose resistance to infection is impaired by disease, burns, etc
Term
vector competence
Definition
ability of a vector to transmit disease.
Term
Morbidity
Definition
Term
Mortality
Definition
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