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- Mitosis promoting factor- mitosis onset, breaks down lamin by phosphorylating serine residues,
Activates condensin, phosphorylates myosin inhibitory site, beaks down mytotic cyclin/CDKs
-made up of 2 subunits, regulatory and catalytic (cyclin/CDK)
Regulatory subunits mentioned- Cyclin B, cdc13
Catalytic subunits mentioned- cdc2, cdc28 |
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Anaphase promoting factor- an E2 ubiquitin conjugating protein, degredation of mitotic cyclins,
Activation requires Cdh1 association |
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– binds and activates APC when unphosphorylated, involved in mitotic cyclin degredation in late
Mitosis, |
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| dephosphorylates Cdh1allowing Cdh1 to bind ACP activating APC/Cdh1 the complex |
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| Phosphorylates inhibitory site (Y15) if cdc2, excess results in long cells |
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| phosphorylates regulatory site of cdc2 |
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| dephosphorylates regulatory site of cdc2 (T161), excess results in small cells |
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| regulatory cyclin/Cdk binds cdc28, initiate S phase, Sic 1 can bind and |
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| inhibitor of S phase initiation |
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| E2 ubiquitin conjugating enzyme degrades Sic1, promotes progression to S phase, regulates CIPS |
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| stimulates transcription of DNA replication genes, as well as more E2F |
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| tumor suppressor- inhibits E2F, phosphorylation by cyclinD/CDK4 causes disassociation from E2F |
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| - tumore supressors, p21, p27, p57, cyclin/CDK inhibitors- p21 inhibits all cyclin/CDKs |
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- tumor suppressor- G1 and G2 arrest, stabilized by DNA damage via ATM/R activates p21,
proapoptotic |
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| tumor suppressor inhibits cyclinD/CDK4, leads to no phosphorylation of Rb |
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