Term
| What 3 receptors does buspirone act on? |
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Definition
5-HT1A - agonist, parial agonist and antagonist
5-HT2
D2 - agonist and antagonist |
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Term
| What is the mechanism of actions of buspirone? |
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Definition
| Presynaptic agonist to 5-HT1A, inhibiting serotonin release. Agonist at post-synaptic receptor - antidepressant effect. |
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Term
| How does buspirone compare with SSRIs or venlafaxine (Effexor)? |
|
Definition
Only effective in GAD.
No sexual dysfunction or weight gain. |
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Term
| Aside from GAD, what are two other indications for buspirone? |
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Definition
Augmentation of SSRIs in depression
Increased arousal and flashbacks in PTSD |
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Term
| Is buspirone considered a lethal drug (in overdoses)? |
|
Definition
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Term
| Buspirone interacts with which two important psychiatric drugs? |
|
Definition
1. Haloperidol - increases plasma levels
2. MAOIs - may cause hypertensive crisis, require 2-week "washout" period |
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Term
| How is buspirone metabolized? |
|
Definition
CYP450 3A4
Drugs of goods that inhibit VYP450 3A4 (e.g. erythromycin, itraconazole, nefazodone, grapefruit juice) result in ↑ buspirone levels |
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