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Bone Tumors
n/a
41
Physiology
Professional
04/03/2014

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Term
Benign tumor-like mass of abnormally dense bone (usually polypoid). Pure compact bone or mixed.
Definition
osteoma
Term
where do osteomas primarily occur?
Definition
skull
Term
what age do osteomas occur?
Definition
40-50
Term
What syndrome are osteomas associated with?
Definition
Gardner’s syndrome (osteomas, epidermal cysts, fibromatoses and colonic adenomatous polyposis)
Term
Benign, highly vascular, sharply circumscribed osteoblastic proliferation. Almost always single. <1.5 cm
Definition
osteoid osteoma
Term
Exquisitely painful, worse at night, relieved by aspirin
Definition
osteoid osteoma
Term
Targetoid appearance on imaging
Definition
osteoid osteoma
Term
what age do osteoid osteomas occur?
Definition
<25
Term
where are osteoid osteomas found?
Definition
Most commonly intracortical. Long bones, especially tibia and femur
Term
what is the most common primary bone tumor?
Definition
osteosarcoma
Term
malignant proliferation of osteoblasts
Definition
osteosarcoma
Term
Codman triangle on Xray
Definition
osteosarcoma
Term
Sunburst tumor
Definition
osteosarcoma
Term
what age do osteosarcomas occur?
Definition
teenagers
Term
where are osteosarcomas found?
Definition
around knee, long bone medullary cavity
Term
benign outgrowth of medullary and cortical bone, covered by a cartilaginous cap
Definition
osteochondroma
Term
Stops growing when skeletal maturity is reached.
Definition
osteochondroma
Term
projects from the cortical surface of the involved bone at the growth plate (metaphysis)
Definition
osteochondroma
Term
when do osteochondromas occur?
Definition
<30
Term
what is the second most common primary bone tumor?
Definition
chondrosarcoma
Term
Can osteochondromas progress to chondrosarcoma?
Definition
yes- 1-2% do
Term
what age does chondrosarcoma occur?
Definition
>40
Term
where does condrosarcoma occur?
Definition
pelvis or central skeleton
Term
metastasizes to lungs, skeleton, SS, skin
Definition
chondrosarcoma
Term
malignant bone tumor derived from neuroectoderm
Definition
Ewing Sarcoma
Term
11;22 translocation
Definition
Ewing Sarcoma
Term
neoplasm of small, round, uniform mesenchymal cells
Definition
Ewing Sarcoma
Term
where is Ewing Sarcoma found?
Definition
diaphysis of long bones
Term
what age does Ewing Sarcoma occur?
Definition
<15 (mostly male)
Term
'onion-skin' appearance on Xray
Definition
Ewing Sarcoma
Term
multi-agent chemo tx
Definition
Ewing Sarcoma
Term
CD99
Definition
Ewing Sarcoma
Term
benign intramedullary proliferation of fibrous tissue and bone. Osseous component has no osteoblastic rimming.
Definition
Fibrous dysplasia
Term
fibrous dysplasia in more than one bone, precocious puberty, cafe-au-lait spots, GNAS1
Definition
McCune-Albright syndrome
Term
benign tumor comprised of multinucleated giant cells (looks like osteoclasts) and stromal cells (epithelioid mononuclear cells)
Definition
Giant Cell Tumor
Term
tumor located in epiphysis
Definition
Giant Cell Tumor
Term
what age does Giant Cell Tumor occur?
Definition
young adults - must be skeletally mature with closed growth plates
Term
locally aggressive benign tumor
Definition
Giant Cell Tumor
Term
15-50% recurrence in 2 years
Definition
Giant Cell Tumor
Term
Adult tumors that metastasize to bone?
Definition
prostate, breast, kidney, lung
Term
Childhood tumors that metastasize to bone?
Definition
neuroblastoma, Wilm’s tumor, rhabdomyosarcoma.
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