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Blood and Lymphatic Disorders
Pathophysiology of Blood and Lymphatic Disorders
98
Nursing
Undergraduate 1
06/27/2013

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Cards

Term
blood functions
Definition
  • transportation (of oxygen, glucose, nutrients, hormones, electrolytes, cell wastes)
  • supplies oxygen and transports waste
  • critical defense mechanism (carries WBCs and immunoglobulins)
  • promotes homeostasis
    • distributes core heat to body
    • maintains blood pressure and fluid levels
    • ready-to-activate clotting factors in blood
    • carbonic acid buffer system maintained in RBCs

 

 

Term
blood components
Definition

Hct (RBCs)

Fibrinogen

Albumin, IgG/IgM, electrolytes

Term
whole blood
Definition
contains all components
Term
plasma
Definition

contains clotting factor (fibrinogen) and Ig's

clear serous fluid left after RBC's removed

Term
plasma proteins
Definition

albumin (made in liver) osmotic press.

globulins/antibodies

fibrinogen (formation of blood clots)

Term
serum
Definition
fluid and solutes remaining after RBCs & fibrinogen are removed (electrolytes and glucose)
Term
hematocrit (Hct)
Definition
  • percentage of RBCs in the blood ("How concentrated is the Kool-Aid?"
  • indicated the viscosity (thickness) of the blood (increased viscosity= increased cardiac workload)
Term
increased Hct
Definition

indicated dehydration or excess RBCs

(dark, thick Kool-Aid= high viscosity blood)

Term
decreased Hct
Definition

indicates blood loss, anemia, or blood dilution

(light, dilute Kool-Aid)

low viscosity blood

Term
normal Hct
Definition
3x Hgb
Term
Erythrocytes
Definition

RBCs

biconcave, flexible discs with thin center

non-nucleated

contains hemoglobin (Hgb): (Iron & Globin)

Term
erythropoeitin
Definition

released by kidneys to stimulate bone marrow to increase RBC production (if not enough O2 is getting to cells)

 

Term
livespan of an RBC
Definition

120 days

phagocytized in spleen or liver, borken into heme + globin units

Term
heme unit
Definition
stored in liver/cells at Ferritin
Term
globin unit
Definition

liver converts to bilirubin for excretion

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

Term
hemoglobin (Hgb)
Definition

major component of Hct

contains 1 ferrous iron atom with 4 globins (proteins) that allow oxygen to attach

 

Term
oxyhemoglobin
Definition

oxygen rich RBCs found in the arterial system

how oxygen gets transported

Term
hemoglobin unit picture
Definition
Term
sickle cell anemia
Definition

a problem with one amino acid, valine

it replaces glutamic acid on the beta chain

Term
affinity of molecules to Hgb in acidosis
Definition
favors O2 release + CO2 binding to heme group (venous) deoxyhemoglobin molecule (without O2)
Term
affinity of molecules to Hgb in alkalosis
Definition
favors CO@ release + O2 binding to heme group (arterial) oxyhemoglobin molecule (with O2 in heme group)
Term
white blood cell components
Definition
  • granulocytes (dark granules on microscopy)
    • neutrophils
    • basophils
    • eosinophils
Term
leukocytes
Definition

white bloos cells (WBCs)

 

Term
leukopoesis
Definition

production of WBCs stimulated by:
"Colony Stimulating Factos" (CSFs)

released by macrophages & T-cells

Term
neutrophil
Definition

granulocyte

most abundant phagocyte in blood

first to respond to tissue damage

immature: called "bands" or "stabs"

increase indicates "left shift," bacterial infection

Term
basophil
Definition

granulocyte

migrate into tissue to become "mast cell" phagocyte

release histamine and heparin, involved in vasodilation

Term
eosinophil
Definition

granulocyte

increased in allergic response (Type 1 reaction)

release histamine

involved in activation of IgE for allergic reaction

Term
monocytes
Definition

agranulocytes

migrate to tissue to become "macrophages"

phagocyte activation with tissue damage

if elevated, suggests "recovery" of infections

Term
lymphocytes
Definition

agranulocytes

T-cells (cell-mediated) and B-cells (humoral)

activated by factos from macrophages, T-cells

increase % suggests viral or fungal infection

"right shift"

Term
differential
Definition
indicates the proportion (%) of the specific types of WBCs in blood
Term
stem cells
Definition
fixed # of stem cells differentiate to different WBC types, according to need
Term
"left shift"
Definition

if bacterial infection

inc neutrophil %

[image]

[image]

Term
"right shift"
Definition

if viral/fungal infection

inc lymphocyte %

[image]

[image]

Term
WBC assembly line
Definition
Term
normal value differential
Definition
[image]
Term
peripheral blood smear
Definition

Term
thrombocytes
Definition
  • another stem cell component
  • platelets (Plt)
  • essential for clotting process (THROMBO=clot)
  • not cells; rather, non-nucleated fragments from large megakaryoblast in bone marrow
  • Plts attach to damaged tissue and each other to form a plug or seal small breaks in vessels
  • platelets also may adhere to foreign material and rough surfaces (stents, etc.)
  • consider them the "roof shingles" of the clot- w/ RBCs and clot protein, form mesh
Term
hemostasis
Definition

coagulation cascade initiated by tissue damage

  • tissue damage- vasoconstriction/vasospasms
    inhibits blood flow to allow platelet plug
  • thrombovytes adhere to tissue underlying damage and create plug; attract coagulation factors
  • coagulation- inactive prothrombin and fibrinogen, combined with platelets and RBCs
    activate clotting cascade to form clot
Term
hemophilia A
Definition

caused by a malfunction with factor 8

normal PT

inc. PTT & APTT

most common type of hemophilia

very common in males, but can only occur in females if mom is a carrier and male has it

 

Term
clotting factors
Definition

fibrinogen

prothrombin

fibrin strands

thrombin

RBCs create "net"

Vit K

Term
fibrinogen
Definition
clotting factor that converts fibring "strands" in clot
Term
prothrombin
Definition
clotting factor that converts to "sticky" thrombin
Term
Vit K
Definition

an essential clotting factor that is a co-enzyme in prothrombin to thrombin

measured in PT/PTT

blocked by Warfarin (Coumadin)

Term
calcium
Definition
essential for many steps in the clotting process
Term
anti-thrombotics
Definition

circulate to prevent inappropriate clot formation

  • anti-thrombin III
  • prostaglandins
  • heparin
Term
anti-thrombin III
Definition
blocks the effects of thrombin
Term
prostaglandins
Definition
inhibit platelet aggregation
Term
heparin
Definition
prevents thrombin and fibrin activation
Term
2 components of blood typing
Definition
  1. A or B antigens present on RBC (A, AB, O type)
  2. Rh antigen present on RBC (Rh type)
Term
type A blood
Definition

RBCs contain A antigens

blood contains anti-B antibodies

can receive only A or O blood type (no anti-A Ab)

Term
type B blood
Definition

RBCs contain B-antigen

blood contains anti-A antibodies

can receive only B or O blood type (no anti-B Ab)

Term
type AB blood
Definition

RBCs contain both A and B antigens

blood contains neither A nor B antibodies

can receive A, B, or O blood type (AB+= universal recipient)

Term
type O blood
Definition

RBCs contain neither A or B antigens (O-neg= universal donor)

blood contains both anti-A and anti-B antibodies

can only receive O type blood (has both A and B Ab)

Term
Rh factor
Definition
either on RBCs (+) or not (-)
Term
Rh neg (-)
Definition

RBCs do not contain the Rh antigen

blood contains Rh antibodies

can only receive Rh- blood

Term
Rh pos (+)
Definition

RBCs contain Rh antigen

blood does NOT contain Rh antibodies

can receive either Rh (+) or Rh (-)

Term
whole blood
Definition
not given to pts very much anymore
Term
PRBC
Definition

packed red blood cells

very commonly given for anemia (given for low hemocrit hematocrit)

prevents hypervolemia that is caused when you give whole blood

 

Term
packed platelets
Definition
for thrombocytopenia or bleeding disorders
Term
plasma
Definition

often Fresh Frozen Plasma (FFP)

contains serum and clotting factors such as fibrogen and prothombin

Term
colloid expanders
Definition

(albumin protein)

can be given without concern for typing and crossmatch (no risk of Type II cytotoxic reaction)

increases osmotic pressure- sucks fluid about of interstitial area

Term
epoetin alfa (Procit, Eprex)
Definition

subcutaneous forms of erythropoietin:

stimulates bone marrow to increase RBC production

Term
bone marrow or stem cell transplants
Definition

for sever immunodeficiencies or "pancytopenia"

(all over decreased bone marrow suppression)

ex. Aplastic Anemia

Term
lymphatic system components
Definition

vessels

nodes- immune "surveillance"

lymphoid tonsils (palatine & pharyngeal)

thymus- behind sternum (T-cells mature)

pleen-lt upper quad

bone marrow (B-cells mature)

Term
lymphatic fluid
Definition
serous fluid similar to plasma but contains higher % of lymphocytes
Term
purpose of the lymphatic system
Definition
  • returns 1-2% of interstitial fluid to the blood
    • lymph blockage= peripheral edema
  • captures unwanted material from body fluid
  • monitors for foreign material
    • initiates immune response (T & B cells)
  • nodes help to determine cancer spread & prognosis
Term
anemias
Definition
  • decreased O2 capacity related to a deficit or abnormality of RBCs (hemocrit and hematocrit are low)
  • 6 main types
    • iron deficiency
    • pernicious
    • aplastic
    • hemolytic
      • sickle cell
      • thalassemia
      • ABO incompatibility
Term
polycythemia
Definition

you have too much RBC

primary or secondary

Term
blood clotting disorders
Definition

excessive bleeding

  • thrombocytopenia- low thrombocytes/platelets
  • hemophilia- main Hemophila A
  • DIC- disseminated intravascular coagulation
Term
myelodysplastic syndromes
Definition

blood cancers

  • leukemias- neoplasm of WBC (super high WBC- in diff, they are all over the place and filled with cancer)
  • lymphoma (T-cell cancer): Hodgkin and non-Hodgkin
  • multiple myeloma (B-cell): plasma cell myeloma

 

Term
anemia in detail
Definition
  • reduced RBCs
  • reduction in oxygen carrying capacity of blood (results in cellular hypoxia)
  • oxygen deficit leads to CNS irritability and
    • low energy; low metabolism; low reproduction
    • compensation mechanism of cellular hypoxia
      • erythropoiesis: renal excretion of erythropoeitin
      • stimulates bone marrow to inc production of RBCs
      • immature RBCs= inc reticulocyte count
    • tachycardia & peripheral vasoconstriction
      • SOB, dyspnea, exercise intolerance, cool skin, fatigue (common signs of any anemia)
    • decreased GI regeneration leads to inflammation/ulcer: stomatitis, chapped lips, dysphagia, brittle hair & nails
Term
complete blood count with differential
Definition

includes WBC count, Hgb, Hct, Platelet count

includes measures of corpuscular RBC morphology

Term
"chromic"
Definition
refers to hemoglobin contenet (Fe++) or cell ("color")
Term
hypochromic
Definition
low Hgb/iron
Term
normochromic
Definition
normal Hgb/iron
Term
"cytic"
Definition
refers to cell size
Term
microcytic
Definition

small cells (usually low Hgb)

 

Term
macrocytic
Definition
large cells (reflects RBC production error)
Term
mean corpuscular volume
Definition

MCV

RBC oxygen carrying capacity/volume of RBC

"chromic" indicator

Term
mean corpuscular hemoglobin content
Definition

MCHC

RBC Hgb content

decreased MCV or MCHC= low Hgb (hypochomic cells)

Term
reticulocyte distribution width
Definition

RDW (D=diameter)

variation in size ("production" problem)

increased RDW= macrocytic cells (termed anisocytosis)

Term
4 classes of anemia
Definition

iron deficiency

pernicious

aplastic

hemolytic

Term
iron deficiency anemia
Definition

 

 

insufficient iron impedes production of RBCs

RBCs are:

·         hypochromic (low iron "color")

·         microcytic (low iron, so low weight) "small cells"

·         decreased Hgb, MC, MCHC

·         RDW unaffected ("factory" ok, just no iron supply)

 

etiology:

·         dietary insufficiency of green veggies and red meat

·         chronic blood loss (GI bleed, heavy menses)

·         poor duodendum absorption or iron

·         sever liver disease (affects blood iron carry capacity)

 

S/S   (universal to all anemias)

·         pallor skin and mucous membranes (vasoconstriction)

·         fatigue, lethargy (cold intoleranc, decreased metabolism)

·         irritability (CNS response to hypoxia)

·         brittle hair and nails

·         stomatitis (mouth sores)

·         menstrual irregularities (often amenorrhea)

·         delayed healing

·         tachycardia (hrt palpitations, dyspnea and syncope)
àif prolonged, can develop hrt failure, angina, MI

 

 

 

Term
pernicious anemia
Definition

 

·         also called megaloblastic anemia

·         characterized by macrocytic, nucleated immature erythrocytes (“production” problem)

 

 

on CBC color will be good, but cells will look enlarged

pathophysiology:

·         a.k.a. B12 deficiency (can only be absorbed in the gut with the aid of intrinsic factor, vital for proper RBC production by bone marrow)

o    IF is secreted by parietal cells in the gastric mucosa and binds to B12  

·         characterized by macrocytic, nucleated immature erythrocytes (“production” problem)

 

Etiology:

·         dietary insufficiency is rare

·         malabsorption of B12 (most common)

o    autoimmune reaction (destroys parietal cells in mucosa)

o    chronic gastritis (alcholics- parietal cells destroyed)

o    surgery (gastrectomy due to cancer, bariatric surgery, etc.)

·         B12 deficiency malabsorption results in macrocytic RBCs- bone marrow “factory” makes “large, sloppy” RBCs, varied sizes, increased variation in size of RBCs (DRW on CBC): anisocytosis

S/S  (in addition to normal anemia signs)

·         Macroglossia (enlarged tongue)

·         Achlorhydria: dec. HCl production from mucosa (confirms pernicious anemia diagnosis)

·         Neurologic effects

o    Tingling or burning sensation caused by peripheral demyelination

o    Loss of coordination (ataxia)

 

 

Diagnostic tests:

·         Microscopy reveals large megaloblastic cells

·         Dec. B12 level

·         Gastric hypochlorydria or achlorhydra (HCl)
àconfirms gastric atrophy of parietal cells

Trmt:

·         Oral supplements: prophylaxis ONLY

·         B12 injections for diagnosed pernicious anemia

 

 

Term
aplastic anemia
Definition

Pancytopenia (pan=global)
(plasti= growth/development)

 

Etiology:

·         Impairment or failure of bone marrow function leading to lack of stem cells to produce erythrocytes, leukocytes, and platelets

May be temporary or permanent

·         Idiopathic (most common)

·         Myelotoxins: chemotherapy, radiation, chemicals, viruses (Hep C)

·         Autoimmune disease : SLE

·         Heredity: myelodysplastic syndrome (Fanconi’s)

S/S

·         All aspects of the bone marrow are affected

o    Anemia: fatigue, pallor, dyspnea, heart failure

o    Leukopenia: opportunistic infections

o    Thrombocytopenia: bleeding tendencies & easy bruising

Diagnostic tests:

·         CBC: neutropenia (low WBCs), MCV/Hgb/Hct low, Plt low (LOW EVERYTHING)

·         Bone marrow biopsy: low reticulocytes & stem cells

Trmt:

·         Treat underlying cause

·         Bone marrow transplant

Term
hemolytic anemia
Definition

 

 

Caused by excessive destruction of RBCs: “hemolysis”

etiology:

·         Genetic defects: sickle cell disease: thalassemia

·         Neoplastic: polycythemia vera (inc in RBC production)

·         Transfusion reactions: cytotoxic type II immune reaction

·         Immune reactions

·         Presence of toxins

·         infections

Term
sickle cell anemia
Definition

Sickle cell anemia (disease)

 

Etiology:

·         Sickle (HgS) gene inherited from parents as homozygous recessive

·         If inherited from both parents: leads to formation of abnormal hemoglobin (HgS)

·         Very common in individuals from African and Middle Eastern decent

·         If you have the trait, you are slightly resistant to malaria

During hypoxia, dehydration, stress: Cells “sickle”

àcause hypoxia and vascular occlusions; very painful

àdamaged RBCs cause increased hemolysis

S/S

·         Severe anemia causing pallor, weakness, tachycardia, and dyspnea

·         Hyperbilirubinemia: jaundice skin and icteric sclera

·         Splenomegaly (spleen filters blood; becomes congested)

·         Vascular occlusions and infarctions lead to periodic painful crisis  (“sickle cell crisis”)

·         Growth and development delays

·         Congestive heart failure: from anemia, increased viscosity, & vascular congestion of occlusions

Diagnostic tests:

·         Hemoglobin electrophoresis

·         DNA testing: for homozygous HgS (heterozygous- no anemia)

Trmt:

·         Hydrea to reduce sickling crisis

·         Avoidance of strenuous activities & high altitudes

·         Prevent dehydration, acidosis, infection, exposure to cold

·         Prophylactic antibiotics

·         In severe cases life expectancy may be as young as 20 years old

Term
sickle cell trait
Definition

someone who is carrying the trait, but will NEVER have a crisis

 

they do NOT have the disease

 

heterozygous

Term
sickle cell disease
Definition

only pts who are going to be susceptible to crisis

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

Term
thalassemia
Definition

Gk: Thalas= sea;  Gk: eamia= blood
*common in people of Mediterranean decent

Pathophysiology:

·         Genetic defect in which one or more of genes for protein portion of hemoglobin (globin) are variant or missing

Hemoglobin has defect with one or more alpha or beta unit

àif 1 globin unit affected: thalassemia minor

àif >1 globin unit affected: thalassemia major (Cooley’s Dz)

Names by which globin affected: alpha or beta

What is the genetic defect of globin?

·         Missing or malfunctioning globin units

·         Accumulation of “extra” globin chains in RBCs

This mismatch of globin subunits:

·         Causes damage and premature destruction of RBCs (hemolysis)

Incidence:

Thalassemia beta: more common in Greece and Italy

Thalassemia alpha: more frequent in Indian, Chinese, and S. Asian descendents

S/S

·         Usual s/s of anemia: pallor, tachycardia, CHF

·         Hyperbilirubemia (Jaundice): iron overload

·         Hyperactive bone marrow (high reticulocyte count)

·         Growth retardation

Diagnostic tests:

·         RBCs are microcytic and hypochronmic (Fe++ not held)

·         Elevated erythropoietin levels

·         High reticulocyte count: (marrow production)

·         Iron studies: iron levels high

Trmt:

·         Blood transfusion

·         Iron chelation therapy- for iron overload

·         Splenectomy may be required

·         Moderate cases survive into their 30s

Term
polycythemia
Definition

Increased RBC count (and other marrow cells)

Pathophysiology:

·         Increased bone marrow stimulation

·         Primary polycythemia (“vera”): noplastic/idiopathic

·         Secondary polycythemia:

o    Hypoxia: lung dz or high altitudes

o    Erythropoietin excretion from tumors (renal carcinoma)

·         Increased production of RBCs, granulocytes, and platelets

·         Serum erythropoietin low

·         Increased blood viscosity and distended vesselsàCHF, HTN

·         Increased thrombocytesà increased risk of thrombosis/infarction

 

S/S

·         Cyanosis

·         Hepatomegaly: congestion

·         Splenomegaly: congestion

·         Pruritis- itching of skin (caused by hyperbilirubin)

·         HTN

·         Headaches

·         Full & bounding pulse

·         Dyspnea

·         Visual disturbances

·         Thrombosis/infarctions

·         CHF: increased blood viscosity

Diagnostic tests:

·         Increased cell counts

·         Increased Hgb/Hct

·         Low erythropoietin

·         Hyperuricemia: *RBC destruction

Trmt:

·         Periodic phlebotomy (“bleed them”- 250cc/2days)

·         Marrow suppression (drugs, radiation)

Term
bleeding disorders
Definition

blood clotting diorders: causes of excessive bleeding

  • htrombocytopenia: low platelet count
  • inherited disorders: hemophilia A (most common)
  • chemotherapy/meds: pancytopenia
  • Vit. K deficiency: cannot activate/fibrinogen
  • certain drugs: heparin, ASA
  • hemorraghic fever viruses

 

Term
hemophilia A
Definition

Classic hemophilia

Pathophysiology:

·         Genetic deficiency of clotting factor VIII

·         Inherited as X-linked recessive trait

·         Manifested in males, but carried in women

·         Varying degrees of severity

·         *hint: hemophilia A-8 (Factor VIII)

 

S/S

·         Prolonged bleeding or persistent oozing after minor trauma

·         Spontaneous hemorrhage into joints (hemarthrosis)

·         Hematuria

·         Blood in the stool (hematochezia)

Diagnostic tests:

·         Bleeding time and PT are normal

·         PTT, APTT and coagulation time are prolonged

·         Low serum Factor VIII

Trmt:

·         Blood transfusions

·         Factor VIII infusions

Term

DIC

disseminated intravascular coagulation

Definition

Pathophysiology:

·         Involves both excessive bleeding due to a deficiency of clotting factors and excessive clotting (thrombus)

·         With cellular damage, both fibrinogen (clot former) and thromboplastin (fibrinolysis) are activated

·         Many small emboli/thrombosis cause tissue damage, while clotting factors (proteins) are used up

·         **Pt simultaneously experiences embolic/thrombotic tissue ischemia (inappropriate clotting) AND bleeding from inability to make clot (exhausted clotting proteins) POOR PROGNOSIS

Etiology:

·         Obstetric complications

·         Toxemia/preeclampsia/amniotic fluid embolus/abruption

·         Infection: gram negative, endotoxins

o    septicemia

S/S

·         hemorrhage/thrombosis/low fibrinogen levels

·         thrombocytopenia/high APTT bleeding times

·         petechiae/bruising

·         infarctions/thrombosis can cause strokes, MI, pulm emboli

·         imflammatory mediators cause vasodilation and septic shock

Term
leukemias
Definition

Group of neoplastic disorders involving WBCs

 

Leukemia named by affected or ID’d type of cell:

·         Acute Lymphocytic Leukemia (ALL)

·         Acute Myelogenous Leukemia (AML)

·         Chronic Lymphocytic Leukemia (CLL)

·         Acute Monocytic Leukemia (CLL)

·          Hairy Cell Leukemia

Pathophysiology:

·         Undifferentiated, immature, nonfunctional leukocytes present and multiplying uncontrollably in the bone marrow.  Large amounts are released into the general circulation.  Very high leukocyte levels (WBC) on CBC.

·         These cells then infiltrate the lymph nodes, spleen, liver, brain, and other organs, causing lymphadenopathy (swelling of lymph nodes).

Etiology:

·         Acute formà younger

o    Childhood leukemia: idiopathic

·         Chronic formà older

o    Adult leukemia: attributed to…

§  Radiation therapy

§  Certain chemicals

§  Certain viruses

§  chemotherapy

S/S

·         multiple infections (treat like the don’t have good WBC count)

·         severe hemorrhage

·         anemia

·         bone pain/Wt loss (bone marrow actually hurts)

·         fever

·         enlarged lymph nodes (lymphadenopathy)

·         Hepatosplenomegaly (irregular cells are trapped in the spleen and liver)

·         CNS:

o    HA, visual changes, drowsiness, vomiting

Diagnostic Tests:

·         Microscopy peripheral smears: leukocytosis (how you see many diff forms & define what type of leukemia)

·         Decreased RBCs and platelets: anemia

·         Bone marrow biopsy confirms diagnosis- you will see undifferentiated cells

Treatments:

·         Chemotherapy (wipe out bone marrow)

·         Proper nutrition

·         Bone marrow transplant (if you can find a match)

 

Term
2 types of lymphatic disorders
Definition
  1. Lymphomas- involves T-Cell proliferation
  2. Multiple myeloma- B-Cell (plasma cell)
Term
lymphomas
Definition

Involve T-cells

Neoplasms involving lymphocyte proliferation in the lymph nodes

Can be Hodgkins or Non-Hodgkins

 

Pathophysiology:

Hodgkins:

·         “orderly spread” (TYPICALLY)

·         Malignancy begins in single node

·         Adjacent nodes are affected in an orderly fashion

·         Then organs are affected through the lymphatic system

·         Classic presentation: single node, then orderly spread

·         Typically, Hodgkin’s better prognosis than non-hodgkins

Non-Hodgkins:

·         “random spread”

Differs from Hodgkins in that…

·         Multiple nodes involved, with NO orderly spread

·         Often affects both sides of body at time of diagnosis

·         Intestinal nodes and abdominal organs involved

·         Non-localized tumors more difficult to treat

·         DOES NOT contain Reed-Sternberg Cells on biopsy

·         Prognosis is improving, but still poor

No known etiology

S/S

·         Painless, non-tender lymph nodes

·         Splenomegaly

·         Wt loss, fatigue, anemia

·         Night sweats, low-grade fever, pruritus (itchy skin)

·         Recurrent infection

·         Hodgkins- linear, symmetrical spread to other nodes- better prognosis (caught sooner)

Diagnostic Tests:

Hodgkins:

·         T-cells appear defective/T-Cell count decreased

·         Reed-Sternberg Cell: definitive cell abnormality for diagnosis

Trmt:

·         Radiation

·         Chemotherapy

·         Surgery

Term
multiple myeloma
Definition

“plasma cell myeloma”

Pathophysiology:

·         Occurs in older adults

·         Neoplasm of plasma cells (mature B lymphocytes)

·         Malignant cells replace bone marrow & erode bones

·         Bone marrow neoplasms lead to decreased B function

·         Decred B-cell function causes decreased immunity

·         Bone breakdown leads to pathologic fractures (your bone broke and then you fell- weird), hypercalcemia

Unknown etiology

S/S

·         Decreased T & B cells production: frequent infections

·         Pain secondary to marrow neoplasm

·         Pathologic fractures and hypercalcemia

·         Thrombocytopenia and anemia

·         Renal failure from hypercalcemia and renal damage

Hypercalcemia:

·         Renal calculi & renal failure (damage to kidney)

·         Excessive calming of skeletal muscles

·         Bounding pulse

Trmt:

·         Chemotherapy

·         Palliative trmt

·         3 yr survival

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