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BioTech FINAL
BioTech FINAL
160
Pharmacology
Graduate
04/23/2012
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Term
Actemra

drug type
 Definition
mab
Term
Actemra

target/mechanism
 Definition
block IL-6 receptor
Term
Actemra

indication
 Definition
rheumatoid arthritis
Term
Actemra

phase
 Definition
marketed
Term
Activase

drug type
 Definition
recombinant protein
Term
Activase

target/mechanism
 Definition
therapeutic delivery of tissue plasminogen
Term
Activase

indication
 Definition
acute myocardial infarction and ischemia
Term
Activase

phase
 Definition
marketed
Term
Albiglutide

drug type
 Definition
recombinant engineered protein
Term
Albiglutide

target/mechanism
 Definition
glucagon like peptide-1 receptor agonist
Term
Albiglutide

indication
 Definition
type 2 diabetes
Term
Albiglutide

phase
 Definition
3
Term
Allostim

drug type
 Definition
heterologous T-cell therapy
Term
Allostim

target/mechanism
 Definition
cancer immune response
Term
Allostim

indication
 Definition
leukemia/myeloma
Term
Allostim

phase
 Definition
1/2
Term
Anakinra

drug type
 Definition
recombinant engineered protein
Term
Anakinra

target/mechanims
 Definition
IL-1 receptor antagonist
Term
Anakinra

indication
 Definition
rheumatoid arthritis
Term
Anakinra

phase
 Definition
marketed
Term
Aranesp

drug type
 Definition
recombinant engineered protein
Term
Aranesp

target/mechanism
 Definition
erythropoiesis stimulation
Term
Aranesp indication
 Definition
anemia of kidney disease and chemotherapy
Term
Aranesp

phase
 Definition
marketed
Term
ATR12181

drug type
 Definition
hypertension vaccine
Term
ATR12181

target/mechanism
 Definition
block angiotensin 1 receptor
Term
ART12181

indication
 Definition
hypertension
Term
ART12181

phase
 Definition
pre-clinical
Term
Avastin

drug type
 Definition
mab
Term
Avastin

target/mechanism
 Definition
decrease VEGF
Term
Avastin

indication
 Definition
glioblastoma and several metastatic cancers
Term
Avastin

phase
 Definition
marketed
Term
Azerra

drug type
 Definition
mab
Term
Azerra

target/mechanism
 Definition
targets CD20
Term
Azerra

indication
 Definition
chronic lymphocytic leukemia
Term
Azerra

phase
 Definition
marketed
Term
Bapineuzumab

drug type
 Definition
mab
Term
Bapineuzumab

target/mechanism
 Definition
decrease beta-amyloid
Term
Bapineuzumab

indication
 Definition
Alzheimer's disease
Term
Bapineuzumab

phase
 Definition
3
Term
Benlysta

drug type
 Definition
mab
Term
Benlysta

target/mechanism
 Definition
lymphocyte stimulator cytokine
Term
Benlysta

indication
 Definition
systemic lupus erythematosis
Term
Benlysta

phase
 Definition
marketed
Term
Brentuximab Vedotin

drug type
 Definition
mab
Term
Brentuximab Vedotin

target/mechanism
 Definition
CD30 directed antibody toxin conjugate
Term
Brentuximab Vedotin

indication
 Definition
Hodgkin lymphoma
Term
Brentuximab Vedotin

phase
 Definition
accelerated approval
Term
CVAC

drug type
 Definition
engineered autologous dendritic cells
Term
CVAC

target/mechanism
 Definition
present mucin-1 antigen
Term
CVAC

indication
 Definition
ovarian cancer vaccine
Term
CVAC

phase
 Definition
2/3
Term
Diamyd

drug type
 Definition
recombinant protein
Term
Diamyd

target/mechanism
 Definition
tolerance induction to beta cell antigen
Term
Diamyd

indication
 Definition
type 1 diabetes vaccine
Term
Diamyd

phase
 Definition
3
Term
Erbitux

drug type
 Definition
mab
Term
Erbitux

target/mechanism
 Definition
block EGF receptor
Term
Erbitux

indication
 Definition
colorectal cancer
Term
Erbitux

phase
 Definition
marketed
Term
Exsulin

drug type
 Definition
synthetic peptide analog
Term
Exulin

target/mechanism
 Definition
pancreatic beta cell progenitor cells
Term
Exsulin

indicaiton
 Definition
type 1 and 2 diabetes
Term
Exsulin

phase`
 Definition
2
Term
Eylea

drug type
 Definition
recombinant fusion protein
Term
Eylea

target/mechanism
 Definition
decrease VEGF
Term
Eylea

indication
 Definition
wet age related macular degeneration
Term
Eylea

phase
 Definition
marketed
Term
Figitumumab

drug type
 Definition
mab
Term
Figitumumab

target/mechanism
 Definition
insulin-like growth factor 1 receptor
Term
Figitumumab

indication
 Definition
Ewing sarcoma
Term
Figitumumab

phase
 Definition
1/2
Term
Fomivirsen

drug type
 Definition
antisense
Term
Fomivirsen

target/mechanism
 Definition
inhibit cytomegalovirus
Term
Fomivirsen

indication
 Definition
CMV retinitis
Term
Fomivirsen

phase
 Definition
withdrawn
Term
Forteo

drug type
 Definition
recombinant peptide analog
Term
Forteo

target/mechanism
 Definition
parathyroid hormone receptor
Term
Forteo

indication
 Definition
osteoporosis
Term
Forteo

phase
 Definition
marketed
Term
Genasense

drug type
 Definition
antisense
Term
Genasense

target/mechanism
 Definition
blocks Bcl-2 to promote apoptosis
Term
Genasense

indication
 Definition
non-Hodgkin lymphoma
Term
Genasense

phase
 Definition
2
Term
Generx

drug type
 Definition
angiogenic gene therapy
Term
Generx

target/mechanism
 Definition
FGF-4 expression
Term
Generx

indication
 Definition
coronary artery disease
Term
Generx

phase
 Definition
3
Term
GVAX

drug type
 Definition
cell therapy
Term
GVAX

target/mechanism
 Definition
irradiated, engineered prostate cancer cells
Term
GVAX

indication
 Definition
advanced prostate cancer
Term
GVAX

phase
 Definition
2
Term
Humira

drug type
 Definition
mab
Term
Humira

target/mechanism
 Definition
decrease TNF-alpha
Term
Humira

indication
 Definition
rheumatoid arthritis
Term
Humira

phase
 Definition
marketed
Term
Ilaris

drug type
 Definition
mab
Term
Ilaris

target/mechanism
 Definition
decrease interleukin 1-beta
Term
Ilaris

indication
 Definition
Cryoporin-Associated Periodic Syndrome
Term
Ilaris

phase
 Definition
marketed
Term
Leukine

drug type
 Definition
recombinant protein
Term
Leukine

target/mechanism
 Definition
GM-CSF augmentation
Term
Leukine

indication
 Definition
chemotherapy/bone marrow transplantation
Term
Leukine

phase
 Definition
marketed
Term
Lucentis

drug type
 Definition
mab
Term
Lucentis

target/mechanism
 Definition
Fab fragment to decrease VEGF
Term
Lucentis

indication
 Definition
wet age related macular degeneration
Term
Lucentis

phase
 Definition
marketed
Term
Oncovex

drug type
 Definition
oncolytic virus gene therapy
Term
Oncovex

target/mechanism
 Definition
infect cancer cells and activate immune response
Term
Oncovex

indication
 Definition
head and neck cancer
Term
Oncovex

phase
 Definition
2
Term
Orencia

drug type
 Definition
ligand-Fc fusion protein
Term
Orencia

target/mechanism
 Definition
CD80/86 of dentritic cells
Term
Orencia

indication
 Definition
rheumatoid arthritis
Term
Orencia

phase
 Definition
marketed
Term
Prochymal

drug type
 Definition
mesenchymal adult stem cells
Term
Prochymal

target/mechanism
 Definition
tissue repair
Term
Prochymal

indication
 Definition
graft versus host and Crohn's disease
Term
Prochymal

phase
 Definition
3
Term
Remicaid

drug type
 Definition
mab
Term
Remicaid

target/mechanism
 Definition
decrease TNF-alpha
Term
Remicaid

indication
 Definition
Crohn's disease
Term
Remicaid

phase
 Definition
marketed
Term
Rituxin

drug type
 Definition
mab
Term
Rituxin

target/mechanism
 Definition
targets CD20
Term
Rituxin

indication
 Definition
non-Hodgkin lymphoma
Term
Rituxin

phase
 Definition
marketed
Term
Samalizumab

drug type
 Definition
mab
Term
Samalizumab

target/mechanism
 Definition
block CD200
Term
Samalizumab

indication
 Definition
B-cell chronic leukemia/multiple myeloma
Term
Samalizumab

phase
 Definition
1/2
Term
Solanezumab

drug type
 Definition
mab
Term
Solanezumab

target/mechanism
 Definition
decrease beta-amyloid
Term
Solanezumab

indication
 Definition
Alzheimer's disease
Term
Solanezumab

phase
 Definition
3
Term
Victoza

drug type
 Definition
recombinant engineered protein
Term
Victoza

target/mechanism
 Definition
glucagon-like peptide-1 receptor agonist
Term
Victoza

indication
 Definition
type 2 diabetes
Term
Victoza

phase
 Definition
marketed
Term
Xgeva

drug type
 Definition
mab
Term
Xgeva

target/mechanism
 Definition
RANK ligand inhibitor
Term
Xgeva

indication
 Definition
bone metastasis
Term
Xgeva

phase
 Definition
marketed
Term
Xolair

drug type
 Definition
mab
Term
Xolair

target/mechanism
 Definition
decrease IgE
Term
Xolair

indication
 Definition
asthma
Term
Xolair

phase
 Definition
marketed
Term
Yervoy

drug type
 Definition
mab
Term
Yervoy

target/mechanism
 Definition
activate cytotoxic T-cells
Term
Yervoy

indication
 Definition
melanoma
Term
Yervoy

phase
 Definition
marketed
Term
Zenapax

drug type
 Definition
mab
Term
Zenapax

target/mechanism
 Definition
block T-cell IL-2 receptor
Term
Zenapax

indication
 Definition
transplant rejection
Term
Zenapax

phase
 Definition
2
Term
Zevalin

drug type
 Definition
mab-radioisotope conjugate
Term
Zevalin

target/mechanism
 Definition
targets CD20 with radiation
Term
Zevalin

indication
 Definition
non-Hodgkin's lymphoma
Term
Zevalin

phase
 Definition
marketed
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