Term
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Definition
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Term
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Definition
-primary mediators of humoral immunity
-membrane bound
-secreted |
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Term
| membrane bound antibodies |
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Definition
-antigen receptor on naive B cells
-BCR
-recognize Ag and intiate humoral response |
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Term
| membrane bound antibodies |
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Definition
-antigen receptor on naive B cells
-BCR
-recognize Ag and initiate humoral response |
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Term
| secreted antibodies (by plasma cells) |
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Definition
-in circulation
-eliminate antigens in effector phase |
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Term
| antigen receptor properties |
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Definition
-recognizes macromolecules, small chemicals, conformational and linear epitopes
-diveristy-each close has a unique specificity
-antigen recognition is mediated by variable regions of heavy and light chains of membrane Ig
-signaling functions are mediated by proteins associated with membrane Ig
-effector functions are mediated by constant regions of secreted Ig |
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Term
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Definition
-participate in antigen recognition
-short stretches of sequence variability |
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Term
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Definition
| -fragment antigen binding |
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Term
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Definition
| mediate antibody effector functions |
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Term
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Definition
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Term
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Definition
| -contribute to inter/intra-chain interactions |
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Term
| each protein domain is made up of |
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Definition
| -2 layers of b-pleated sheets and held together by disulfide bond |
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Term
| An Ag binding site is formed from |
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Definition
| the hypervariable regions of a heavy chain V domain and light chain V domain |
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Term
| each variable region contains |
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Definition
-3 CDRs (interacts with antigen)
-complemenatarity determining region
- |
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Term
| epitope (antigenic determinant) |
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Definition
| part of the antigen recognized by antibody |
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Term
| antibody mediated effector functions |
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Definition
-neutralization (microbes, toxins)
-activation of complement (innate immunity, forms pores, enhances inflammatory)
-opsinization leads to phagocytosis
-antibody mediated cellular cytotoxicity (ADCC, NK cells)
-Hypersensitivity (mast cell activation, overreaction of immune system) |
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Term
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Definition
-GAMED
-G is most abundant and so on |
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Term
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Definition
-4 binding sites max
-mucosal immunity
-neonatal passive immunity
-defense against resp/GI infections |
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Term
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Definition
-no binding sites
-naive B cell Ag receptor |
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Term
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Definition
-monomer
-mast cell activation
-allergic responses |
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Term
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Definition
-monomer
-serum conc 13.5mg/ml
-serum half life 23days
-opsinization, complement activation, ADCC, neonatal immunity
-induced by common vaccines |
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Term
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Definition
-pentamer
-naive B cell Ag receptor, complement activation |
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Term
| Ag binding sites vary depending on the |
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Definition
| -property of the antigenic determinant |
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Term
| conformational determinant |
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Definition
| -determinant lost by denaturation |
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Term
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Definition
| -Ig binds to determinant in denatured protein only or binds to both native and denatured protein |
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Term
| flexible hinge region allows the Ig |
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Definition
| to bind with both arms to many different arrangement of Ags on the surface of pathogens (widely or closely) |
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Term
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Definition
-strength of binding of a monovalent Ag to a single Ag-binding site on an antibody
-10^-6M to 10^-9M |
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Term
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Definition
-number of Ag molecules that can bind an antibody
-multivalent Ag with different epitopes
-polyvalent Ag with a repeated epitope |
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Term
| features of antibody recognition |
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Definition
-antigen binding
-specificity
-diversity
-affinity maturation |
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Term
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Definition
-CDRs of Vh and Vl
-linear and conformational determinants of macromolecule and small chemicals |
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Term
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Definition
| -distinguish between small differences in chemical structure |
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Term
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Definition
-generation of Ig diversity in B cells occur before encounter with antigen
-somatic (DNA) recombination |
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Term
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Definition
| -point mutations in variable chains that increases the affinity of the antibody for the antigen |
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Term
| epitope specificity ever change? |
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Definition
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Term
| antibody goes through structural changes but |
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Definition
| never changes original Ag specificity |
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