Term
| cells of adaptive immune response |
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Definition
-Antigen specific lymphocytes (recognize/respond to one Ag)
-APCs
-Effector cells/responses (locate and destroy microbes, different effector functions for different microbes, adaptive) |
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Term
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Definition
-capture antigen
-display to lymphocytes (present peptide antigen and provide 2nd signal)
-provide signals that stimulate proliferation and differentiation of lymphocytes |
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Term
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Definition
-macrophage (cell mediated immune response)
-B cell (humoral mediated immune response)
-all nucleated cells are important APCs for CTLs
-only cells that can make antibodies
- |
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Term
| antigen specific naive T cells recognize antigen and |
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Definition
| produce effector responses |
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Term
| Dc carry pathogens to the draining lymph node where |
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Definition
| they stimulate naive T cells |
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Term
| how do pathogens that infect non professional APCs get recognized by naive T cells |
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Definition
| -DC: cross presentation (3rd party antigen acquisition) |
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Term
| how are Ags recognized and displayed to naive T cells |
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Definition
-MHC restricted (only recognize when complexed with MHC)
-Dual Specificity
-peptide display molecule |
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Term
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Definition
-function-display microbe associated antigens for recognition by T-cells
-features-extracellular peptide-binding cleft
-2 non covalently linked chains |
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Term
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Definition
-bind killer CD8 t-cells
-alpha 1,2,3 |
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Term
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Definition
-bind to helper CD4 t-cells
-alpha 1,2 and beta 1,2 |
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Term
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Definition
-co-dominant expression
-polymorphic genes
-MHC expressing cell types |
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Term
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Definition
-both parental alleles of each MHC gene are expressed
-inc number of different MHC molecules that can present peptides to T cells |
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Term
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Definition
-many different alleles are present in the population
-ability to respond to different microbes |
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Term
| MHC expressing cell types |
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Definition
-Class II-professional APCs, macrophages, B cells
-Class I-all nucleated cells |
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Term
| features of peptide binding |
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Definition
-broad specificity (many different peptides can bind to same MHC molecule)
-each MHC molecule displays one peptide at a time (each T cell responds to a single peptide bound to an MHC molecule)
-MHC molecules bind peptides only (MHC restricted T cells respond only to proein antigens and not to other chemicals) |
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Term
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Definition
-common structural features promote interaction
-broad specificity
-class I MHC molecules bind 8-11 AAs
-class II MHC molecules bind 10-30 AAs |
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Term
| more features of peptide binding |
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Definition
-peptides are acquired during intracellular assembly (antigen processing)
-stable surface expression of MHC molecule requires bound peptide (display self and nonself peptide antigens)
-very slow off rate (maximize T cell recognition) |
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Term
| exposures to pathogens selects for |
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Definition
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Term
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Definition
-(internalization by receptor mediated or antibody mediated endocytosis, phagocytosis)
-microbe attachment
-internalization and degradation
-invariant chain-CLIP/DM processing
-peptide loading
-stable expression |
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Term
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Definition
-CLass II Invarient Chain Peptide
-surrogate peptide
-binds MHC II when synthesized in ER |
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Term
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Definition
| swithces CLIP for bacterial peptide |
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Term
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Definition
-(used for viruses and microbes that have escaped phagosomes)
-cytosolic-dervied microbial protein
-tagged for degradation
-peptide transport via TAP
-peptide loading
-stable expression |
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Term
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Definition
-tags proteins to be sent to proteosome?
-peptide transport to ER |
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Term
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Definition
| -breaks down viral proteins to small peptides |
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Term
| lymphocytes role in adaptive immunity |
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Definition
-specificity and memory
-specific receptors for antigen recognition (t-cell-TCR,b-cell-membrane bound antibody, BCR)
-b-cells produce antibodies
-t-cells mediate cellular immunity
-exceptions-lack diversity |
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Term
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Definition
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Term
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Definition
-bone marrow, thymus
-function-mature and develop lymphocytes |
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Term
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Definition
-lymph node, spleen
-concentrate antigen
-promote cell cell interaction for antigen presentation
-activate adaptive immunity |
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Term
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Definition
-home to peripheral lymphoid organ
-no effector function
-no proliferation |
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Term
| effector (activated) t-cells |
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Definition
-migrate to inflamed site
-cytokine secretion, cytotoxic activity
-proliferation |
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Term
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Definition
-migrate to peripheral lymphoid organs
-proliferation |
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Term
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Definition
-migrate to inflamed site
-perform effector functions |
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Term
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Definition
| -how t cells enter lymph cells |
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Term
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Definition
| -naive t-cells continuously recirculates through lymph nodes until it encounters 'right' antigen (becomes activated) |
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