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Biology 214 Exam 4
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108
Biology
Undergraduate 1
12/12/2009

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Term
epistasis
Definition
The interaction between products of one loci with another.
Term
polygenic
Definition
inheritance of a phenotypic characteristic that varies in degree and can be attributed to the interactions between two or more genes and their environment.
Term
Haplotype
Definition
haploid genotype, multilocus genotype of a chromosome or gamete (gametic phase)
Term
Linkage disequilibrium
Definition
the non-random association of alleles at two or more loci, not necessarily on the same chromosome
Term
Linkage
Definition
describes the association of two or more loci on a chromosome with limited recombination between them.
Term
Recombination
Definition
the process by which a strand of genetic material is broken and then joined to a another DNA molecule. This may happen during meiosis of a diploid organism that sexually reproduces or may be something like conjugation in bacteria where there is an exchange of DNA between two haploid individuals.
Term
Homologous recombination
Definition
a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA
Term
Recombination rate
Definition
proportion of gametes that are recombinant. Range from 0 to .5
If on different chromosomes then recombination
rate is going to be 0.5 (Mendel’s 2nd Law)
Term
Coefficient of Linkage disequilibrium
Definition
D = fABfab-fAbfaB
Term
maximum value is 0.25
Definition
when AB and ab are the only chromosomes and at equal frequency
Term
minimum value is -0.25
Definition
when Ab and aB are the only chromosomes and at equal frequency
Term
causes of Linkage disequilibrium
Definition
Selection
Mutation
Population admixture (gene flow), a.k.a. hybridization
Genetic drift
Term
does not cause Linkage disequilibrium
Definition
Physical linkage (no matter how close)
Inbreeding
Term
Decline in LD Equation
Definition
D’ = D(1-r)
D = fABfab-fAbfaB
r= recomb rate between (0-0.5)
Term
Muller's ratchet
Definition
Asexual populations accumulate deleterious mutations
Term
genetic load
Definition
Burden imposed by accumulation of mildly deleterious alleles
Term
Quantitative genetics
Definition
a field of evolutionary biology that examines the evolution of continuously variable traits that are influenced by the combined effects of genotype at >1 locus and the environment.
Term
Quantitative traits
Definition
characters with continuously distributed phenotypes (e.g., height, beak depth in finches)
Term
Heritability
Definition
fraction of the total phenotypic variation in a trait that is due to variation in genes
Term
Phenotypic variation (VP)
Definition
variation due to genetics (VG) and to environment (VE); VP = VG + VE
Term
Broad Sense Heritability
Definition
VG / VP = VG /(VG + VE)
Term
Genetic variation (VG)
Definition
= variation due to additive genetics (VA) and dominance (VD); VG = VA + VD
Term
Narrow Sense Heritability (h2)
Definition
VA / VP = VA /(VA + VG + VD)
Term
Selection differential (S)
Definition
Difference between trait mean of breeders (t*) and trait mean of entire population ( t )
Term
Selection gradient (β)
Definition
β = S/var(t)
slope of relative fitness to trait value
Term
Breeder’s equation
Definition
R = h^2^SThe response to selection (R) is just the difference between the mean of the parents before selection and the mean of the offspring.
Term
Directional Selection
Definition
Changes average value of trait (increases or decreases)

Variance gets a little smaller
Term
Stabilizing Selection
Definition
Average value of trait does not change

Variance gets smaller
Term
disruptive Selection
Definition
Average value of trait does not change

Variance gets larger
Term
Kin Selection-CASS
Definition
Cooperative, Altrustic, Selfish, Spiteful
Term
Kin selection- Coefficients of relatedness (r)
Definition
probability that the homologous alleles in two individuals are identical by descent
Term
Hamilton’s rule
Definition
Br – C > 0
r = relatedness between actor and recipient
B = benefit to recipient and C = cost to the actor, both measured in units of surviving offspring
Term
Inclusive fitness
Definition
direct fitness (own reproduction) + indirect fitness (reproduction from relatives)
Term
Sexual selection
Definition
selection that arises from competition for access to mating opportunities or fertilizations.
Term
Bateman's principles
Definition
1.A high variance in mating success is a sign of sexual selection.

2.A high variance in reproductive success (fitness) is another sign of sexual selection.

3. A positive relationship between mating success and reproductive success is the cause of sexual selection.
Term
Limiting resources for fitness
Definition
Females limited by quality, males limited by quantity, shallower Bateman gradient vs. steeper batemen gradient
Term
Intrasexual selection
Definition
Traits that allow one to directly compete with members of the same sex for mating opportunities
Term
Intersexual selection
Definition
Traits that attract potential mates
Term
Secondary Sex traits
Definition
All differences between the sexes except for genitalia and gonads.
Term
Fisherian selection
Definition
A population-wide preference for certain trait values can evolve simply due to the increase in frequency of those trait values.

The Fisherian mechanism says that sexual selection by female choice can cause genetic correlations between male traits and female preferences.
Term
adaptation
Definition
-A trait (or group of traits) that increases the fitness of its possessor, relative to those without the trait.

-A trait is an adaptation for some function if it has become prevalent or is maintained in a population because of selection for that function.
Term
Not everything that “looks” like an adaptation actually is an adaptation:
Definition
A trait may be a necessary consequence of physics or chemistry.
The trait may have evolved by random genetic drift rather than by natural selection.
The feature may have evolved not because it conferred an adaptive advantage, but because it was correlated with a trait that did.
The character state may be a consequence of phylogenetic history.
Term
METHODS FOR RECOGNIZING ADAPTATIONS
Definition
experiments, observational studies, the comparative method
Term
Phenotypic Plasticity
Definition
genetic variation for the extent to which a trait is phenotypically plastic (genotype-by-environment interaction).
Term
Senescence
Definition
The decline in an individual’s ability to reproduce and survive over time.
Term
Senescence
Definition
The decline in an individual’s ability to reproduce and survive over time.
Term
The Rate-of-Living Theory of Aging
Definition
Cellular damage due to errors made by biochemical machinery and the accumulation of toxins directly causes senescence.
Term
The Evolutionary Theory of Aging
Definition
Aging occurs because repairs to cell and tissue damage are biologically possible, but organisms simply do not evolve complete repair abilities due to constraints.

These constraints are the product of
1.) deleterious mutations, or
2.) trade-offs between repair and reproduction.
Term
The mutation accumulation hypothesis
Definition
Slightly deleterious mutations that result in decreased longevity only slightly decrease fitness, because the effect is near the end of the lifespan, which few individuals reach anyway.
Term
The antagonistic pleiotropy hypothesis
Definition
A mutation causes an increase in fecundity earlier in the life span, at the expense of a shortened total life span.
Term
Lack’s hypothesis
Definition
selection will favor the “clutch size” that produces the highest offspring survival.
Term
Morphospecies
Definition
species based on morphological differences/similarities
Term
Morphospecies advantages
Definition
Can use on extant and extinct taxa
Often used as first means for identification
Easy to collect
Term
Morphospecies disadvantages
Definition
What delineates a new species—how much difference?
Some organisms have limited morphology to work with (e.g., bacteria)
Cryptic species (morphologically indistinguishable, but genetically distinct)
Sexual dimorphism – need to define for males and females
Term
Biological Species Concept
Definition
Species are groups of interbreeding natural populations that are reproductively isolated from other such groups
Term
Biological Species Concept Advantages
Definition
Focuses on evolutionary mechanism –gene flow
Provides a more objective criterion than morphospecies concept
Term
Biological Species Concept disadvantages
Definition
Largely focuses on a single evolutionary mechanism—gene flow.
What about organisms with asexual reproduction?
What about fossils where cannot test reproductive isolation?
Reproductive compatibility is a pleisiomorphic character (although reproductive compatibility does not have to equal reproductive isolation as isolation can occur by other means)
Term
Phylogenetic Species concept
Definition
defines species as the smallest diagnosable monophyletic group - species are evolutionarily independent long enough for "diagnostic" traits to appear
Term
Phylogenetic Species concept advantages
Definition
Can use on extant and extinct taxa
Molecular data make it feasible to test in most if not all extant taxa
Can use regardless of reproductive mode
Term
Phylogenetic Species concept disadvantages
Definition
It may be that each population is actually a distinct species according to PSC (although not a problem with the concept, but how we handle the organization of so many possible “species”)
Need to be cautious of horizontal gene transfer (e.g., especially bacteria) because can create incorrect phylogeny.
Term
Phyletic speciation
Definition
gradual change through time within a lineage (similar to chronospecies)
Term
hybridization
Definition
Fusion of two species to form a new species
Term
Cladogenesis
Definition
origin of new lineage— “splitting of lineages-- instanteous or gradual
Term
Allopatric
Definition
physical isolation creates an effective barrier to gene flow—now other evolutionary mechanisms result in divergence
Term
Parapatric
Definition
habitat is continuous between the populations that are diverging into separate species
Term
Sympatric
Definition
– refers to the formation of two or more descendant species from a single ancestral species all occupying the same geographic location
Term
Reinforcement
Definition
natural selection that results in a mechanism to prevent hybridization among individuals of diverged populations that are now in secondary contact
Term
prezygotic isolation
Definition
mechanisms that prevent fertilization (behavioral, physiological etc
Term
postzygotic isolation
Definition
hybrid offspring are sterile or infertile
Term
Hybrid zone maintenance
Definition
Hybrids are maintained because they have higher fitness in zone of contact relative to parental populations
Term
Microparasites
Definition
bacteria, viruses, protozoa, fungi
- multiply within host (multiple generations)
- acute infections (host death or immunity)
Term
Macroparasites
Definition
helminths (e.g., nematodes, flatworms), arthropods
- release eggs or larvae into external environment
- chronic infections (morbidity not mortality
Term
Kingdom Protozoa
Phylum Sarcomastigophora
Definition
*amoeba and flagellates
Entamoeba, Trichomonas, Giardia, Leishmania, Trypanosoma
Term
Kingdom Protozoa
Phylum Apicomplexa
Definition
Phylum Apicomplexa
malaria, Eimeria, Toxoplasma, Cryptosporidium
Term
Phylum Sarcomastigophora
Definition
Entamoeba histolytica and Giardia intestinalis
-asexual reproduction within host
Cyst in feces
Term
Trypanosoma brucei
*T. b. gambiense
*T. b. rhodesiense
Definition
African sleeping sickness, Take blood meal, deposit parasite, asexual reproduction in blood, taken out of blood by parasite, multiples within blood of midgut of fly, then grows, and then injects next human
Term
Trypanosoma cruzi
Definition
Assassin/kissing bugs, in bug feces, scratches skin, parasite in through wound, asexually reproduce in infected tissues, taken out in blood meal, finalizes growth in midgut of parasite
Term
Leishmania spp.
Definition
Cutaneous leishmaniasis
Visceral leishmaniasis (kala-azar

Mucocutaneous leishmaniasis- Sandfly
transform inside marcophages, taken in blood meal, final growth in sandfly
Term
Toxoplasma gondii
Definition
Felids are final host
sexual and asexual reproduction in cats
asexual in all other hosts
Term
Phylum Platyhelminthes
Definition
flatworms
contains free living species
almost all hermaphroditic
parasitic groups: cestodes, digeneans, mongeneans
Term
Phylum Nematoda
Definition
roundworms
free living, plant parasites, and animal parasites
more than one origin of animal parasitism
Term
Phylum Platyhelminthes
Class Trematoda
Definition
6000 species
usually, two suckers
Usually 3 host life cycle
and snail first host, flukes final host
Term
Schistosoma mansoni
Definition
swimmers itch
Term
Fascioloides magna-deer liver fluke
Definition
Final host (eg deer) eats vegetation with paraiste—excysts and penertrates gut wall and migrates to liver.
Term
Fasciola hepatica
Definition
sheep liver fluke
Term
Phylum Platyhelminthes
Class Monogenea
Definition
usually have a simple life cycle involving hermaphroditic adults, eggs and larvae
Term
Phylum Platyhelminthes
Class Cestoda
Definition
Typically, adults inhabit the intestines of their hosts, being anchored to the intestinal via a scolex, followed by a series of repeated reproductive segments called proglottids
Term
Phylum Platyhelminthes
Class Cestoda
Taenia solium
Definition
Humans can be both
final and intermediate
host
Term
Phylum Platyhelminthes
Class Cestoda
Echinococcus granulosus
Definition
Canids final host
if humans get then larvae can
migrate to most tissues and
form hydatid cyst (asexual
reproduction in cyst)
hydatid disease
Term
Phylum Nematoda

Ascaris lumbricoides
Definition
human roundworm in gut
Term
Phylum Nematoda

Hookworms
Ancylostoma duodenale, Necator americanus
Definition
larvae cannot mature further in the human host
Term
Phylum Nematoda

Trichinella spiralis
Definition
undercooked pork consumed by humans, larvae deposited, grow within body
Term
Filarial nematodes
Definition
Infective larvae are transmitted by infected biting arthropods during a blood meal
Term
Dirofilaria immitis
Definition
Dirofilaria immitis –dog heartworm
Term
Wuchereria bancrofti
Definition
elphantiasis)
tropical areas worldwide
lymphatic infection
Term
Onchocerca volvulus
Definition
river sickness
Term
Phylum Acanthocephala
Definition
Spiny headed worms (proboscis with spines)

Dioecious intestinal parasites with no intestine

Vertebrate final hosts, arthropod intermediate hosts
Term
Phylum Pentastomida
Definition
Adults in lungs and respiratory systems
of land-living carnivorous vertebrates
Term
Dicrocoelium dendriticum
Definition
cow poop, to snails, to ant, to cows and humans, adults are in humans
Term
Prevalence
Definition
percent hosts infected
Term
Mean abundance
Definition
mean number of parasites per host examined
Term
Mean intensity
Definition
mean number of parasites per infected host
Term
Infrapopulation
Definition
all the parasites of a species within a host individual
Term
Component population
Definition
all the parasites of a species within a host population
Term
Toxicology indicators
Definition
some parasites can accumulate heavy metals to concentrations orders of magnitude higher than those in the host tissues or the environment.
Term
Biotags
Definition
using parasites to indentify host origins, migrations, or stocks
Term
Food web dynamics
Definition
indicators of host diet – “ghosts of food items”
Term
Indicators of ecosystem health
Definition
many parasites have complex life cycles, so presence of parasite indicates presence of all hosts need for life cycle
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