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Biology 1403 Test 3
Reproductive, Genetics ect.
128
Biology
Undergraduate 1
11/03/2011

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Term
Menstruation
Definition
1. Hypothalamus releases GnRH into pituitary
2. Pituitary releases FSH
3. Developing egg releases more and more estrogen
4. Peak levels of LH cause ovulation from follicles
5.Corpus luteum remains in ovary then begins to break down
Term
What secretes GnRH?
Definition
Hypothalymus
Term
Vas Deferens
Definition
Sperm are propelled from the epididymus through the vas deferens to the ejaculatory duct.
Term
Seminal Vesicals
Definition
Produce 60-70% of semen fluid.
- Fructose: Energy for mitochondria
- Prostiglandins: Smooth muscle contraction
- Alkaline
- Seminolplasmin antibiotic
Term
Prostate Gland
Definition
- Secretes products directly into the urethra through small ducts
- Thin, milky fluid
- Anticoagulant enzymes and citrate(sperm nutrient)
Term
Epididymus
Definition
From the seminiferous tubules of a testis, the sperm pass into the coiled duct of the epididymis.

During this passage the sperm complete maturation and become motile. (Acquire the ability to fertilize egg)
Term
Erectile Tissue
Definition
Corpora Cavernosum and Corpus Spongiosum

Become erect when NO is produced.
Term
Glans
Definition
Head of clitoris
Term
Prepuce
Definition
Small hood of the skin covering the glans, or head of the clitoris
Term
Testes
Definition
Produce sperm in highly coiled tubes called Seminiferous Tubules.
Term
Bulbourethral Gland (Cowper's Gland)
Definition
A pair of small glands along the urethra below the prostate. Before ejaculation they secret a mucus that neutralizes any acidic urine.

"PRE-CUM"
Term
Scrotum
Definition
A fold of the body wall, maintains the testes temperature a few degrees lower that the rest of the body.
Term
Seminiferous Tubules
Definition
Highly coiled tubes inside the testes that produce sperm.
Term
Leydig Cells
Definition
Interstitial cells.

Found adjacent to the seminiferous tubules in the testicle. They produce testosterone in the presence of luteinizing hormone (LH).
Term
Interstitial Cells
Definition
Cells that produce testosterone laying between seminiferous tubules.
Term
Sertoli Cells
Definition
Supporting "nurse" cells inside seminiferous tubules. Tall, columnar cells that extend the full thickness of the epithelium from its base to the lumen of the seminiferous tubule. It is activated by follicle-stimulating hormone and has FSH-receptor on its membranes.
Term
Spermatid
Definition
The spermatid is the haploid male gametid that results from division of secondary spermatocytes. As a result of meiosis, each spermatid contains only half of the genetic material present in the original primary spermatocyte.
Term
Sertoli Cells Funcitons
Definition
- Blood Testis Barrier
- Secrete Hormones(not testosterone)
- Mullenian Inhibiting Factor(Stops formation of Fallopian tubes)
- Inhibits production of FSH
- Adrogen Binding Protein
- Support for sperm development
Term
What are the components of Semen?
Definition
<5% - Epididymus: Sperm + Fluid
~60% - Seminal Vesicals
- Fructose: Energy for mitochondria
- Prostiglandins: Smooth muscle contraction
- Alkaline
- Fibrinogen into Fibrin
- Seminoplasmic antibiotic
~30% - Prostatic Secretion
- Calcium ions
- Zinc ion
- Enzymes
- Converts fibrinogen into fibrin with Prostate Specific Antigen (PSA)
5% - Cowper's Secretion: "Pre-Cum"
Term
Process of Getting an Erection
Definition
Autonomic nervous system produces nitric oxide which relaxes smooth muscle allowing betting blood flow.
Term
Spermatogenesis
Definition
Production of sperm
Term
Rete Testes
Definition
The rete testis is located within the mediastinum testis and gives rise to several ducts that join a tube called the epididymis
Term
Efferent Ductules
Definition
The vessels of the rete testis terminate in 7-13 ducts, called the "efferent ductuli," which carry the seminal fluid from the testis to the epididymis. Their course is straight at first and then becomes convoluted to form a series of conical masses which together form the head of the epididymis.
Term
Androgen
Definition
Name for sex hormones

ex. Testosterone
Term
Ovarian Cycle of the Human Female
Definition
1. Release of GnRH from the hypothalamus
2. Anterior Pituitary stimulated to produce FSH and LH
3. FSH Stimulates follicles aided by LH
4. Cells of the growing follicles start to make estradiol
5. Estradiol secretion by the growing follicle begins to rise steadily
6. The FSH and LH levels increase markedly
7. The maturing follicle containing a fluid-filled cavity enlarges forming a bulge near the surface of the ovary
8. LH stimulates the follicular tissue left behind to transform into a corpus luteum.
Term
When does the follicular phase end?
Definition
At ovulation about a day after the LH surge.
Term
What path does sperm follow before entering the ejaculatory gland?
Definition
1. Seminiferous Tubules
2. Rete testes
3. Efferent Ductules
4. Epididymis
5. Vas Deferens
Term
Mullenian Inhibiting Factor
Definition
Inhibits the formation of Fallopian tubes
Term
Falopian Tube
Definition
Extends from the uterus to each ovary with the diameter differing in size as it's length with the diameter near the uterus being as thin as human hair.
Term
Fibraie
Definition
Collect egg once ovulating
Term
Endometrium
Definition
The inner lining of the uterus. Richly supplied with blood vessels.
Term
Uterus
Definition
Also known as the womb. Thick muscular organ that can accommodate a 4kg fetus.
Term
Cervix
Definition
The neck of the uterus, opens into the vagina.
Term
Ovaries
Definition
Female gonads that flank the uterus and are held in place in the abdominal cavity by ligaments. The outer layer is packed with follicles, each consisting of an oocyte, a partially developed egg, surrounded by a group of support cells.

Have about 1-2 Million follicles at birth and only about 500 fully mature between puberty and menopause.
Term
Hymen
Definition
Partially covers the vaginal opening in humans at birth and usually until intercourse or vigorous physical activity ruptures it.
Term
Myometrium
Definition
Is the middle layer of the uterine wall, consisting mainly of uterine smooth muscle cells. Its main function is to induce uterine contractions.
Term
Cervical Canal
Definition
It communicates with the uterine cavity via the internal orifice of the uterus, and with the vagina via the external orifice.
Term
Oviduct
Definition
A Fallopian tube.

Extends from the uterus to each ovary with the diameter differing in size as it's length with the diameter near the uterus being as thin as human hair.
Term
Clitoris Components
Definition
1. Body
2. Glans
3. Prepuce
Term
Labia Minora
Definition
Slender skin folds that borders the vaginal opening
Term
Labia Majora
Definition
A pair of thick fatty ridges that enclose and protect the rest of the vulva.
Term
Follicles
Definition
The basic units of female reproductive biology, each of which is composed of roughly spherical aggregations of cells found in the ovary. They contain a single oocyte.
Term
Uterine Wall
Definition
Wall of the uterus that embryos attach to to receive nutrients from the mother's bloodstream.
Term
Estradiol
Definition
Term
FSH
Definition
Term
LH
Definition
A hormone produced by the anterior pituitary gland. In females, an acute rise of LH called the LH surge triggers ovulation and development of the corpus luteum. In males, where LH had also been called interstitial cell-stimulating hormone (ICSH), it stimulates Leydig cell production of testosterone. It acts synergistically with FSH.
Term
Vulva
Definition
Collective term for the outside of the female genitalia.
Term
Oocyte
Definition
Partially developed egg, surrounded by a group of support cells that nourish and protect the oocyte during much of the formation and development of the egg.
Term
Female gonads
Definition
Ovaries, flank the uterus and are held in place in the abdominal cavity by ligaments. The outer layer is packed with follicles, each consisting of an oocyte, a partially developed egg, surrounded by a group of support cells.

Have about 1-2 Million follicles at birth and only about 500 fully mature between puberty and menopause.
Term
Endometriosis
Definition
A female health disorder that occurs when cells from the lining of the womb (uterus) grow in other areas of the body.
Term
Skene's gland
Definition
Known as the female prostate and contributes to female ejaculation.
Term
Bartholin's Gland
Definition
They secrete mucus to lubricate the vagina and are homologous to bulbourethral glands in males.

"PRE-CUM"
Term
What is the female hormonal cycle
Definition
1. Luteinizing hormone rises and stimulates the follicle to produce estrogen

2. As estrogen is produced by the follicle, estrogen levels rise inhibiting the output of LH

3. Estrogen levels continue to rise to the threshold level at which point the negative feedback is reversed and LH surges

4. Ovulation occurs just after the LH surge damaging the estrogen-producing cells which results in a decline in estrogen

5. The LH surge results in the establishment of the corpus luteum -- an estrogen and progesterone secreting gland

6. Estrogen and progesterone serum levels climb steadily, supressing LH output

7. Lack of LH promotes the degeneration of the corpus luteum

8. Cessation of corpus luteum activity means a decline in estrogen and progesterone output

9. The decline in the ovarian hormones ends their negative effect on the secretion of LH

10. LH is secreted and the cycle begins again
Term
[image]
Definition
1. Centriole
2. Mitochondrial Sheath (Spiral shaped)
Term
[image]
Definition
A. LH
B. Progesterone
C. Estrogen
Term
Estrous Cycle
Definition
A type of reproductive cycle in all female mammals except higher primates, in which the nonpregnant endometrium is reabsorbed rather than shed, and sexual response occurs only during mid–cycle at estrus.
Term
Menarche
Definition
Onset of puberty (age 10-12)
Term
Testis is to Ovaries as Scrotum is to _______?
Definition
Labia Majora
Term
Wild Type Allele
Definition
a) Functional gene product
b) Most likely prevalent in the population
Term
Types of mutated alleles
Definition
a) No gene product
- Non sense
b) Less effective
c) More effective
d) New gene product
e) Harmful gene product
Term
Haplo-sufficient
Definition
1 Allele produces same phenotype as 2 would. Half of the enzyme (gene product) is enough to produce wild type.

Also called Completely Dominant

Example with Albinos

AA = Pigmented
aa = Albino
Aa = Pigmented
Term
Haplo-insufficient
Definition
Heterozygotes have an INTERMEDIATE phenotype

RR - Red
R'R' - White
RR' - Pink

Also called Incompletely dominant or partially dominant.
Term
Receptor Mediated Endocytosis

H - Wild type transporter
h - No transporter

HH - Wild type - ~200mg/dL
Hh - - ~600mg/dL
hh - - >1200mg/dL

Is this haplo-insufficient or haplo-sufficient?
Definition
Haplo-insufficient
Term
R' - Red
R" - White
T - Tall
t - Dwarf

Heterogeneous is crossed with a white dwarf. How many possible phenotypes are there?
Definition
R'R"Tt x R"R"tt

TR'
TR"
tR'
tT"

4 possibilities
Term
R' - Red
R" - White
T - Tall
t - Dwarf

Heterogeneous is crossed with a white dwarf. How many possible phenotypes are there?
Definition
R'R"Tt x R"R"tt

TR'
TR"
tR'
tT"

4 possibilities
Term
Huntington's Disease

What age is the onset? Life expectancy post onset?

H - Huntington's
h - Wild Type

hh - Wild type
HH - Huntington's
Hh - Huntington's

Is this haplo-sufficient or haplo-insufficient?

Hh x hh = What % chance of getting Huntington's?
Definition
35 years
10 years

Haplo-Sufficient

Hh x hh = 50% chance
Hh
Hh
hh
hh
Term
Codominance in Parakeets

F' - Blue
F" - Yellow

What are the resulting possible phenotypes?
Definition
F'F' - Blue
F"F" - Yellow
F'F" - Green
Term
MN Blood group

M - Glycogen M
N - Glycogen N

What are the phenotypes?
Definition
MM - Glycogen Type M
NN - Glycogen Type N
MN - Glycogen Type MN

Codominance
Term
Ovulation
Definition
During a typical 4-week menstrual cycle, one follicle matures and expels it's egg.
Term
What happens during Spermotogenesis?
Definition
[image]
Term
What happens during Oogenesis?
Definition
[image]
Term
Acrosome
Definition
A vesicle at the tip of the sperm cell that contains enzymes that help the sperm penetrate the egg.
Term
What is the endometrium's response when.

A. GnRH rate is slow
B. GnRH rate is fast
C. GnRH ceases
Definition
A. Thickening
B. Maturing
C. Sloughed
Term
Menopause
Definition
The permanent cessation of ovulation and menstruation.
Term
Gametogenesis
Definition
The process by which gametes are produced in mammalian bodies.
Term
Primary Oocytes
Definition
Immature oocytes that remain quiescent within small follicles until puberty when hormones reactivate them.
Term
Phases of the Uterine Cycle
Definition
Proliferation phase; secretory phase; menstrual flow phase
Term
Luteal Phase
Definition
That portion of the ovarian cycle during which endocrine cells of the corpus luteum secrete female hormones.
Term
Ovarian Cycle
Definition
The cyclic recurrence of the follicular phase, ovulation, and the luteal phase in the mammalian ovary, regulated by hormones.
Term
Menstrual Cycle
Definition
A type of reproductive cycle in higher female primates, in which the nonpregnant endometrium is shed as a bloody discharge through the cervix into the vagina.
Term
Secondary Oocytes
Definition
Oocytes arrested at metaphase II that are released only when matured; follicle breaks open at that point.
Term
Proliferative Phase
Definition
That portion of the uterine (menstrual) cycle when the endometrium regenerates and thickens.
Term
Phases of the Ovarian Cycle
Definition
Follicular phase; ovulation; luteal phase.
Term
Menstrual Flow Phase
Definition
That portion of the uterine (menstrual) cycle when menstrual bleeding occurs.
Term
Oogenesis
Definition
The development of mature ova
Term
Spermatogonia
Definition
Stem cells that give rise to sperm
Term
Secretory Phase
Definition
That portion of the uterine (menstrual) cycle when the endometrium continues to thicken, becomes more vascularized, and develops glands that secrete a fluid rich in glycogen.
Term
The Uterine Cycle
Definition
The changes that occur in the uterus during the reproductive cycle of the human female; also called the menstrual cycle.
Term
Follicular Phase
Definition
That part of the ovarian cycle during which follicles are growing and oocytes maturing.
Term
Spermatogenesis
Definition
The development of mature sperm cells.
Term
Ovulation
Definition
The release of an egg from ovaries. In humans, an ovarian follicle releases an egg during each uterine (menstrual) cycle.
Term
Oogenia
Definition
Ovary-specific stem cells
Term
Codominance
Definition
Two alleles both affect the phenotype inseparate distinguishable ways
Term
Amniocentesis
Definition
Testing done on a fetus at 14 to 18 weeks by inserting a needle into the uterus and removing amniotic fluid to be used for testing for genetic disorders.
Term
Polygenic Inheritance
Definition
An additive effect for two or more genes on a single phenotypic character
Term
Pleiotrophy
Definition
A single gene affects several phenotypic characters
Term
Incomplete Dominance
Definition
When a phenotype is somewhere between the two parental varieties.
Term
Epistasis
Definition

A gene at one locus alters phenotypic expression of gene at second locus.

 

[image]

 

 

Term
Complete Dominance (Haplo-Sufficient)
Definition
The phenotypes of heterozygote and the dominant homozygote are undistiguishable
Term
Genetic Rules
Definition
Alternative versions of genes account for variantion in inherited characteristics.
For each charater an organism inherits two alleles on from each parent
if the two allels at a locus differ the dominant allele determines the phenotype, the recessive allele is rarely shown.
Term
Multiple Alleles
Definition
When genes exist in more than two allelic forms.

ie. Blood types
Term
Character
Definition
A heritable feature that varies among individuals.
Term
Fetoscopy
Definition
A needle thin tube with viewing scope and fiber optics is inserted into uterus
Term
Multifactorial Disorders
Definition
genetic component plus a signigicant An An environmental component that contributes to a disease.

Such as heart disease, diabetes, cancer, alcoholism, and certain mental illnesses(schizophrenia and bipolar disorder).

In many cases, the heredity component is polygenic.
Term
Quantitative Characters
Definition
Characters that vary in the population along a continuum.
Term
At the physiological starting point of the menstrual cycle order in which these hormones peak?

FSH
Progesterone
Estrogen
LH
Definition
1. FSH
2. Estrogen
3. LH
4. Progesterone
Term
When does implantation occur?
Definition
7 days after fertaliztion
Term
From the navel toward the groin. In what sequence should the following structures appear in a normal male

1. Cowper’s Glands
2. Internal Urethral Sphincter
3. Seminal Vesicles
4. Prostate Gland
5. Ureters
Definition
5. Ureters
3. Seminal Vesicles
2. Internal Urethral Sphincter
4. Prostate Gland
1. Cowper's Gland
Term
What is the proper anatomical arrangement of the following structures, proceeding from posterior to anterior?

1. Clitoris
2. Urethral Orifice
3. Vaginal Orifice
4. Mons Pubis
5. Anus
Definition
5. Anus
3. Vaginal Oriface
2. Urethral Oriface
1. Clitoris
4. Anus
Term
What are the sites of action of these components of semen.

1. Acrosomal Enzymes
2. Prostiglandins
3. Prostate Enzymes
4. Alkaline Secretions
5. Fructose
Definition
1. Egg Cell
2. Vaginal Wall
3. Vagina
4. Vagina, male urethra
5. Mitochondria
Term
hCG
Definition
Human Chorionic Gonadotropin

Mimics LH in maintaining secretion of progesterone and estrogens by the corpus luteum through the first few months of pregnancy. Secreted by the embryo to signal its presence.
Term
If no hCG was produced what would occur?
Definition
The corpus luteum would deteriorate and progesterone levels would drop, resulting in menstruation and loss of the embryo.
Term
Levels of what hormone in the maternal blood are so high they are excreted in urine and it's presence is the basis of early pregnancy tests.
Definition
hCG
Term
Gestation
Definition
Pregnancy, the condition of carrying one or more embryos in the uterus.
Term
Cleavage
Definition
Division of the zygote about 24 hours after contraception.
Term
Blastocyst
Definition
A sphere of cells surrounding a central cavity. Produced by cleavage after about 5 days. Implanted into the endometrium after about 7 days.
Term
How does a the embryo receive nourishment prior to implantation?
Definition
Endometrial secretions
Term
Trophoblast
Definition
Cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg.
Term
Chorion
Definition
The chorion consists of two layers: an outer formed by the trophoblast, and an inner formed by the somatic mesoderm; the amnion is in contact with the latter.
Term
Chorionic Villi
Definition
Villi extending from the chorion that maximizes area of contact to maternal blood. Works as an exchange between the maternal blood and the fetal placenta.
Term
GnRH
Definition
Responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released from neurons within the hypothalamus.
Term
These two hormones regulate gametogenesis directly, by targeting tissues in the gonads, as well as indirectly by regulating sex hormone production.
Definition
FSH and LH
Term
What are the principle sex hormones in males and females?
Definition
Males: Androgens, especially testosterone

Females: Estrogens, especially estradiol and progesterone
Term
In the testis ____ stimulates sertoli cells, which nourish developing sperm. ____ stimulates the production of androgens(mainly testosterone), which in turn stimulate sperm production.
Definition
1. FSH
2. LH
Term
In both males and females, ____ encourages the growth of cells that support and nourish developing gametes(follicle cells in females and sertoli cells in males), and ____ stimulates the production of sex hormones that promote gametogenesis
Definition
1. FSH
2. LH
Term
Mesolecithal
Definition
Meaning they contain moderate amounts of yolk in a gradient.
Term
The different cells derived from cleavage are called ___________ and form a compact mass called the _________. Cleavage ends with the formation of the __________.
Definition
1. Blastomeres
2. Morula
3. Blastula
Term
Which of these processes still appear to be occurring in such individuals at maturity?

1. menstruation 2. ovulation 3. GnRH secretion 4. gonadotropin secretion 5. human chorionic gonadotropin (HCG) secretion
Definition
3. GnRH secretion 4. gonadotropin secretion
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