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Biologics for cancer
Therapy Final
13
Pharmacology
Professional
12/08/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
tamoxifen
Definition
selective estrogen receptor modifiers (SERMs); complete binding of estrogen
Term
LH-RH analogues
Definition
Gosrelin, Leuprolide
Term
anti-androgens
Definition
bicalutamide, fludamide, nilutamide, abiraterone, enzalutamide
Term
aromatase inhibitors
Definition
anastrozole, letrozole, exemestane
Term
rituxumab
Definition
recognized CD20 B Cell specific (non-hodgkins lymphoma, serous infusion rxns)
Term
trastuzumab (Herceptin)
Definition
HER-2 positive breast cancer, blocks HER2 signaling, causes cardiotoxicity
Term
bevacizumab (Avastin)
Definition
binds vascular endothelial growth factor (VEGF), Metastatic cancer, toxicity: impaired wound healing, GI perforation and HTN
Term
cetuximab (Erbitux)
Definition
binds epidermal growth factor receptor (EGFR), colorectal head and neck lung
Term
sipuleucel-T (Provenge)
Definition
metastatic prostatic cancer, process where you take out own APC cells out, get modified to stimulate T cells, then reinfused to have T cell attack prostate cancer
Term
tyrosine kinase inhibitors
Definition
the NIBs and that all I am going to say...sorry but he lists five million and Im pissed and I hate this and why did I do pharmacy
Term
vemurafenib (zelboraf)
Definition
BRAF kinase inhibitor, oral for metastatic melanoma with BRAF mutation
Term
Everolimus (Afinitor)
Definition
mTOR kinase inhibitor, breast pancreatic and renal
Term
vismodegib (Erivedge)
Definition
hedgehog pathway inhibitor for metastatic basal cell cancer
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