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Biochemistry II
Lecture 2
29
Biochemistry
Undergraduate 4
01/23/2013

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Term
What type of glycerol is a glycerophospholipid? where is its group attached
Definition
1,2 diacylglycerol
Phosphate is attached at the c3 of glycerol
Term
Why is Glycerol prochiral?
Definition
attachment of phosphate turns achiral glycerol into chiral molecule
Term
What is the structure of Phosphatidic acid ? why is it important
Definition
1,2 diacy 3 phosphate
its an important intermediate in biosynthesis of the more common glycerophospholipids
Term
Ether Glycerophospholipid ?
Definition
ether linkage instead of ester at c1
Term
Platlet activating factor? Important in what
Definition
is an ether glycerophospholipid and due to its c2 acetate group is more water soluble than counterparts. Plays a role in signal transduction
Term
What is a Sphingolipid?
Diffences between glycerol
Definition
18 carbon amino hydroxyl backbone.
Difference between glycero is the amide linkage of fatty acid at c2.
Term
Sphingolipids can only have?
Definition
one fatty acid residue
Term
What are Sphingomyelins and what are they important in
Definition
They are sphingolipids with either phosphorylcholine or phosphorylethanolamine substituent at c1 hydroxyl of ceramide.
They important in nervous tissue
Term
What are glycosphingolipids and what and where  is there linkage at?
Definition
sphingolipids with one or more sugars in a beta linkage at c1 of glycerol
Term
What is a Cerebroside ?
Definition
a glycosphingolipid with one sugar
Term
What is a Ganglioside
Definition
Sphingolipid with 3 or more sugars
Term
how are waxes made ?
what is there general formula
Definition
an LONG CHAIN alchohols and LONG CHAIN carboxyl esterfied together
R-O-cO-R
Term
What is a terpene? what is the name of its subunit? systemtic? how many carbons does it have?
Definition
combination of isoprene units ( either head totail or tail to tail) 2-methyl-1,3-butadiene 5 carbons
Term
What is a Monoterpene? how many carbons
Definition
two isoprene units , 10 carbons
Term
What are Sesquiterpenes ? how many carbons
Definition
3 isoprenes, 15 carbons
Term
What is a Diterpene
Definition
4 isprene units, 20 carbons
Term
what is a Gonane? why is it important
Definition
A Gonane is 3 sixmembered rings and 1 five membered ring. It is the Strucurual motif common in ALLL STERIODS !!!
Term
What is the most common steriod in animals? Why is it important ?
Definition
Cholestrol, important because it is a precursor for all other molecules
Term
draw out the structure of cholestrol
Definition
Term
What are common characteristics of steriod structure
Definition
methyl at 10, 13
8-12 carbon alkyl group at 17
Term
cholestrol in Plasma membranes vs intracellular membranes
Definition
More in Plasma membrane than in intracellular membrane
Term
What effect does the c3 hydroxyl of cholestrol have on it?
Definition
it makes it weakly polar
Term
Amphipathic polar nature of cholestrol allowsw it to?
Definition
enter and disrupt mebbranes and their packing
Term
Steriod carrier protein carriers affinity? so what?
Definition
they have a high affinity for their steriods which means only small concentration of steriod needed to form response
Term
What are the five classes of hormones (and there functions) synthesized from cholestrol
Definition
Androgens (sexual characteristics and sexual function) ,estrogens(dido) , progestens(regulate menstruation) , corticosteriods( control metabolism) , mineralocorticoids( control ion balances)
Term
estradiol is a ?
Definition
androgen
Term
what are bile acids
Definition
detergent molecules secreted by the gull bladder to aid in the absorption of dietary lipeds
Term
Characteristics of Lipid signals
Definition
Act Locally
Very short lifetime
Term
What enzymes produce signal products?What are the different types of them and what do each one of them do.
Definition
Phospholipases.
A1-cleave (hydrolyze) c1 fatty acid
A2- cleave c2 fatty acid
C-hydrolyze phosphate on glycerol side
D-hydrolzye phosphate on polar head group side
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