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Definition
inhibits transcription
intercalates into double helix
Extremely toxic, used as cancer drug |
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Inhibits BACTERIAL RNA Polymerase II
Inhibits Prokaryotic transcription |
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Inhibits eukaryotic RNA Polymerase II
Cannot be used...Toxic |
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| What three things are needed for Transcription? |
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Definition
DNA
RNA Polymerase
ATP, GTP, UTP, CTP |
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ensures RNA Polymerase binds at promotor
Needed for initiation
NOT needed for elongation |
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Nucleoplasm
mRNA, snRNA
Does NOT bind sequence specifically |
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| Brings RNA Polymerase II to the DNA |
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Phosphorylates C-terminal domain
Unwinds DNA
Allows polymerase to escape promoter and start synthesis |
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Definition
Binds to DNA
Has TATA Binding Protein |
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| Potential Eukaryotic Promotor Sequences |
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Definition
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| position and orientation independent |
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5' - 5' linkage
Protects from degradation |
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2' - 5' UNUSUAL LINKAGE
intron (cut out) |
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| Improper splicing Clinical Disorder |
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