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BIOA01 MODULE 1 Lec 11
Lecture 11 Module 1 Cellular respiration
23
Biology
Undergraduate 1
09/30/2013

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Term

Briefly describe cellular respiration.

 

Definition
A collection of metabolic reactions that break down food molecules to produce ATP.
Term
True or false : Fat, Carbs and protein can be used in cellular respiration to produce ATP.
Definition
True, they can all be used for cellular respiration
Term

What is the most common energy molecule?

 

How much energy does it yield when fully converted.

Definition

Sugar glucose C6H1206

 

Yields -686kcal/mol when fully converted

Term

Cellular respiration is highly _________

but drives ___________ synthesis of ATP

Definition

Exergonic

 

Endergonic

Term

Multi step chemical reactions catalyzed by enzymes involve ___________.

 

List two the types of "_________"

Definition

Energy transfer

 

1) Electron Tranfer (Redox reactions)

2) Phosphate transfer (ATP hydrolysis / synthesis)

Term

Oxidation ________ energy. Therefore it is _________

 

Reduction __________ energy. Therefore it is ________

Definition

1) Releases, exergonic.

2) Consumes, endergonic.

Term

What is a redox reaction? What is the reducing agent and what is the oxidizing agent?

 

Where does the energy go?

Definition

Redox reaction - Removing electron from a donor molecule and adding it to an acceptor molecule

 

e donor is the reducing agent

e acceptor is the oxidizing agent

 

Energy liberated from the reducing agent is captured by the oxidizing agent

Term
Some redox reaations do not transfer electrons but _________________
Definition
instead alter the electron sharing in covalent bonds
Term

List two ways that glucose can be oxidized by C02.

 

Which yields more free energy?

 

 

Definition

1) By Combustion

2) By Metabolism

 

1) Combustion - 1 step. Large activiation energy. All free energy released as heat

 

2) Metabolism- Multiple steps. Smaller activation energies. Yields free energy and heat, free energy is transferred out by carrier protein.

 

Term

 

What is the most common electron carrier?

Definition

Most common electron carrier is Coenzyme NAD+.

 

Term

There are three stages of cellular respiration.

 

List them and briefly describe them.

Definition

1. Glycolysis

2. Pyruvate oxidation and citric acid cycle

3. Oxidative phosphorylation

 

Glycolysis - Breakdown of a molecule of glucose into two molecules of pyruvate.

 

Pyruvate oxidation and citric acid cycle - Oxidation of Pyruvate from Acetyl CoA

Acetyl CoA oxidized into CO2

ATP and NADH synthesized

 

Oxidative phosphorylation - NADH synthesized in step 1 and 2 is oxidized

e- passes along ETC to 02

-> Proton Gradient -> Synthesize ATP

Term

Look back at pages 13, 14, 15

 

UNDERSTAND THEM

 

 

Definition
13,14,15
Term

What is Glycolysis?

 

Does glycolysis occur in the cytoplasm of ALL cells (Prokaryotes AND Eukaryotes)

 

What are its two main phases?

 

Is it aerobic or anaerobic?

 

What does it provide starting materials for?

Definition

Glycolysis is the breakdown of glucose into two molecules of pyruvate

 

Occurs in cytoplasm of ALL cells

 

Two major phases : Energy investment : First 5 reactions are endergonic

 

Energy Payoff : Last 5 reactions are exergonic

 

It is anaerobic.

 

Provides starting materials for fermentation (anaerobic) and cellular respiration (aerobic)

 

 

Term
What are the two major things that happens in energy investment reactions?
Definition

Reactions 1 to 3 : Pi and ATP are added to Carbon 6 and Carbon 1 of glucose to form fructose 1,6-biphosphate

 

Reactions 4-5 : Enzyme aldolase splits 1,6-biphosphate into two 3C molecules. (Turns it into G3P)

Term
What are the two major things that happen in the energy payoff reactions?
Definition

2 Molecules of G3P were made before this so.

 

1) 2NADH + 2H^+ are produced via redox reaction (Pi added to each of the G3P involved)

 

2) 4 ATP produced via substrate level phosphorylation

(2 Pi per molecule, 2 molecules = 4 ATP synthesized)

Term

How many ATP used in glycolysis per glucose molecule?

 

How many ATP produced in glycolysis per glucose molecule?

 

Yield per glucose molecule?

Definition

2 ATP used per glucose molecule.

4 ATP produced in glycolysis per glucose.

 

2 ATP yielded per glucose in glycolysis

Term

What is substrate level phosphorylation? Describe how it works.

 

How does it produce ATP?

Definition

Substrate level phospharylation is a enzyme driven reaction that produces ATP.

 

It produces ATP by an enzyme making the substrate give its phosphate group to ADP.

Term
How does the energy investing reactions work?
Definition

The energy investing reactions are endergonic reactions COUPLED with exergonic ATP hydrolysis (ATP gives it energy) to overcome an activation energy.

 

 

Term
Energy harvesting reactions are __________ reactions.
Definition
Exergonic reactions where ATP is formed through substrate level phosphorylation.
Term

When no oxygen is available, cells use ____________.

 

What does "_________" do?

 

Where does "_________" occur?

 

How does it recycle?

 

Glucose is _______ oxidized from "__________"

Definition

Fermentation

 

Fermentation permits the production of ATP when there is no 02.

 

Fermentation happens in the cytoplasm.

 

Involves recycling via redox reactions

 

Partially, Fermentation

Term

There are two types of fermentation, list them.

 

 

Definition

Lactate fermentation

Alcoholic fermentation

 

Term
Fermentation regenerates ________. Why does it do this?
Definition

Fermentation regenerates NAD+. It does this because reduction of pyruvate consumes NADH and it needs NADH!

 

 

Term
Fermentation _______ pyruvate into __________.
Definition
Reduces pyruvate into lactate or ethanol.
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