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BIO110FINAL
CellBioFinalSlugosomes
29
Biology
Undergraduate 3
06/09/2010

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Term
XMAP215
Definition
Microtubule Associated Proteins- stabilizes plus ends microtubules
Term
MAP2
Definition
Microtuble Associated Proteins- holds microtubules at a longer distance
Term
Tau
Definition

Microtubule Associated Protein-

holds microtubules at a shorter distance

Term
Stathmin
Definition
Microtubule Associated Proteins- Binds microtubule subunits so that it prevents assembly
Term
Gelsolin
Definition
Severs filaments and binds to the plus end
Term
Arp Complex
Definition
Can bind to actin filaments making a meshwork
Term
Profilin
Definition
Recruits actin subunits and speeds elongation
Term
Thymosin
Definition
Binds actin subunits and prevents elongation
Term
Formin
Definition
Nucleates assembly (easier to start with) and actin subunits add on
Term
ERM Proteins
Definition
Recruit actin to membranes by binding receptors
Term
Kinesin- 4,10
Definition
Moves chromosomes to the plus end (away from centrosome)
Term
Kinesin-5
Definition
Two pairs of legs (no head) plus end directed (away from centrosome) resulting in MTs pulling apart
Term
Kinesin-14
Definition
Minus end directed (towards centrosome) bringing MTs together closer
Term
Dynein
Definition
Minus end directed (towards centrosome) head on PM and legs on MT. Pulls centrosomes apart
Term

G-Protein Calcium Pathway

 

Definition
Vasopressin binds receptor and induces a conformational change
Gα becomes activated by binding GTP
Gα dissociates from βγ subunits
Gα actiates phospholipase C
PLC cleaves PI 4,5 bisphosphate (PIP2) into IP3 and DAG
IP3 diffuses and opens ER localized Ca2+| channels
Term
Gamma Tubulin
Definition
Acts as a precursor to MT formation
Term
Hsp70 & BIP
Definition
chaperone
Term
KDEL sequence
Definition

proteins in the ER have this sequence.

If accidentally goes to golgi (low pH, acidic), has receptors with high affinity. Low affinity at ER, proteins come off

Term
SAR1
Definition
recruits COPII at ER (GTPases)
Term
ARF
Definition
recruits Clathrin and COP1 at golgi (ATPase)
Term
co-translationally translocated
Definition
made in a lill protein (eg. Na+ K+ pump do this)
Term
SRP protein
Definition
Ribonuclearprotein that holds translation in rough ER, faces the cytosol
Term
Stages of Cancer
Definition
Normal epithelium-> polyp->dislasia->carcinoma in situ->malignant carcinoma(metastisis)
Term
G-Protein Pathway: Production of cAMP
Definition
[image]
Term
G-Protein: Ca Channel Regulation
Definition
[image]
Term
Calmodulin as a Memory Protein
Definition
[image]
Term
Entry into Mitosis
Definition
[image]
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