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bio test 1
chapter 4
50
Biology
Undergraduate 1
02/21/2012

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Term
Energy is defined as
Definition
the capacity to do work
Term
What are the two states of energy?
Definition
kinetic
potential
Term
kinetic energy
Definition
energy of an object in motion
Term
potential energy
Definition
stored energy
Term
Define thermodynamics.
Definition
The study of energy and its transformations
Term
When discussing thermodynamics, the object under study is called
Definition
the system
Term
What are the three kinds of systems?
Definition
isolated system
closed system
open system
Term
isolated system
Definition
matter and energy cannot be exchanged
Term
closed system
Definition
energy can get in and out, matter can’t
Term
open system
Definition
matter and energy can get in and out
Term
All living systems must be what system?
Definition
an open system
Term
All living systems must be an open system
Why?
Definition
Nutrient has to come in, waste has to come out, exchange materials, or it will die
Term
First law of thermodynamics states:
Definition
Energy can transformed from one form to another, or transferred from one location to another, but can’t be created or destroyed
Term
Second law of thermodynamics states:
Definition
The total disorder (entropy) of a system and its surroundings always increases
Term
Define spontaneous reaction.
Definition
Chemical or physical reaction that will occur without an input of energy
Term
What is free energy?
Definition
the portion of a system’s energy that is available to do work
Term
What is the equation used to calculate change in free energy?
Definition
∆G = ∆H – T∆S
Term
AH
Definition
is the change in enthalpy (potential energy in its system)
Term
T
Definition
is the absolute temp in degrees Kelvin (K)
Term
∆S
Definition
is the change in entropy
Term
Exergonic reactions will do what to energy?
Definition
release energy
Term
Endergonic reactions will do what to energy?
Definition
absorb energy
Term
Reactions will be spontaneous if
Definition
the products have less potential energy than the reactants
Term
Change in Entropy
Reactions will be spontaneous when
Definition
the products are less ordered than the reactants
Term
For a reaction to be spontaneous, change in free energy must be
Definition
negative
Term
Catabolic pathway
Definition
energy is released by the breakdown of complex molecules to simpler compounds (spontaneous)
Term
Anabolic pathway
Definition
energy is used to build complicated molecules from simpler ones
Term
Most biological reactions have a
Definition
positive ∆G
Term
Therefore must have ? to provide the needed energy to make the reactions go forward.
Definition
ATP
Term
How does ATP provide energy?
Definition
Removal of one or two phosphate groups
Term
How much energy is released during the hydrolysis of ATP?
Definition
∆G = -7.3 kcal/mol
Term
During energy coupling, what happens to the terminal phosphate group when ATP is being hydrolyzed?
Definition
Transferred to a reactant molecule involved in an endergonic reaction
Term
addition of the phosphate group to the reactant is called
Definition
phospholation.
Term
Even when a reaction is spontaneous, the reaction will not start unless a small amount of
? is added.
Definition
Activation energy (E_a)
Term
The most common biological catalysts to make a reaction go faster are
Definition
enzymes
Term
How do enzymes increase the rate of reactions?
Definition
Lowering the activating energy of the reaction
Term
By looking at the name of an enzyme, how can one determine that it is an enzyme?
Definition
-ase (ex; proteinases)
Term
The reactant the enzyme acts on is called
Definition
the substrate
Term
What is the active site?
Definition
small pocket or groove in the enzyme molecule
Term
What goes into the active site?
Definition
substrate
Term
What are cofactors?
Definition
A nonprtein group that binds to the enzyme
Term
Examples of cofactors?
Definition
metallic ions, zinc, ir, copper, magnesium, manganese
Term
What are coenzymes? Examples of coenzymes?
Definition
Small organic molecule, vitamins
Term
What are the different factors that can affect enzyme activity?
Definition
1. concentration of substrate
2. inhibitors
3. regulation of enzymes
4. pH
5. temperature
Term
What are the two different kinds of inhibitors?
Definition
competitive inhibition
non competitive inhibititor
Term
competitive inhibition
Definition
bind to the active site
Term
non competitive inhibititor
Definition
bind at location other than the active site
Term
What are the two ways to regulate enzyme activity?
Definition
Allosteric
Feedback inhibition
Term
Allosteric
Definition
enzyme activity is controlled by the regulatory molecule to the allosteric site, a location on the enzyme outside the active site
Term
Feedback inhibition
Definition
excess accumulation of a product often inhibits the enzymatic reaction producing it
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