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Bio 211 circulatory system OCTC
Bio 211 circulatory sys, test #3, OCTC fall 2012
216
Biology
Undergraduate 2
10/22/2012

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Term
study of the heart and treatment of its disorders
Definition
cardiology
Term
cardiovascular sys consists of
Definition
heart
BV
Term
muscular pump that keeps blood flowing
Definition
heart
Term
deliver blood to organs and return blood to the heart
Definition
BV
Term
BV include (7)
Definition
aorta
arteries
arterioles
capillaries
venules
veins
venae caveae
Term
carry blood to the heart
Definition
vein
Term
carry blood away from the heart
Definition
artery
Term
circulatory sys is a broader term and consists of (3)
Definition
heart
BV
blood
Term
2 main divisions of cardiovascular system
Definition
pulmonary circuit
systemic circuit
Term
which circuit deals with right side of heart carrying blood to lungs for gas exchange and returns it to the heart
Definition
pulmonary circuit
Term
which circuit deals with left side of heart supplying blood to all organs of the body, parts of the lungs, and the wall of heart itself
Definition
systemic circuit
Term
pathway of pulmonary circuit
Definition
1 r. atrium receives deoxygenated blood from body cells
2 r. av valve
3 r. ventricle
4 pulmonary valve
5 pulmonary trunk
6 divides into r./l. pulmonary a.
7 lung (gas exchange)
8 oxygenated blood leaves lung by way of r./l. pulmonary v.
9 l. atrium
Term
pathway of systemic circuit
Definition
1 l. atrium receives oxygenated blood from lungs
2 l. av valve
3 l. ventricle
4 aortic valve
5 aorta
6 branches into arteries, arterioles, capillaries (gas/nutrient & waste exchange), venules, veins, SVC, IVC
7 deoxygenated blood into r. atrium
Term
arteries are ___
violets are ___
except in the ___
where the ___ is true
Definition
red
blue
lungs
opposite
Term
gas exchange and nutrient/waste exchange occurs where
Definition
capillaries
Term
major arteries/veins entering and leaving the heart
Definition
great vessels
Term
aorta and pulmonary trunk --> r./l. pulmonary arteries are great ___
Definition
great arteries
Term
SVC/IVC and coronary sinus and r./l. pulmonary veins are great ___
Definition
great veins
Term
position of heart
Definition
in thoracic cavity
in mediastinum
medial to lungs
deep to sternum
anterior to body of thoracic vert.
superior to diaphragm
tilted to the left
Term
broad, superior portion with the point of attachment of great vessels
Definition
base
Term
inferior end that tapers to blunt point, tilts to left immediately superior to diaphragm
Definition
apex
Term
heart is enclosed in double-walled sac of 2-layered membrane called the
Definition
pericardium
Term
outer wall of pericardium is
Definition
parietal pericardium or pericardial sac
Term
2 layers of pericardial sac
Definition
fibrous layer - dense irregular CT
serous layer - thin areolar CT
Term
serous layer of parietal pericardium folds back on itself to form the
Definition
visceral pericardium or epicardium
Term
space between the visceral and parietal pericardium
Definition
pericardial cavity
Term
what lubricates the pericardial cavity which lubricates membranes and allows the heart to beat with minimal friction
Definition
pericardial fluid
Term
3 layers of heart wall
Definition
epicardium
myocardium
endocardium
Term
thick cardiac muscle
Definition
myocardium
Term
is continuous with endothelium of BV
Definition
endocardium
Term
4 chambers of the heart
Definition
r./l. atrium
r./l. ventricle
Term
what chambers receive blood returning to heart
Definition
r./l. atria
Term
small ear like extension that increase capacity of both atria
Definition
auricle
Term
receives deoxygenated blood from the body
Definition
r. atrium
Term
receives oxygenated blood from the lungs
Definition
l. atrium
Term
cardiac muscle that separates r. and l. atria
Definition
interatrial septum
Term
remnant of foramen ovale
Definition
fossa ovalis
Term
remnant of ductus arteriosus
Definition
ligamentum arteriosum
Term
allow fetal blood to bypass lungs (2)
Definition
foramen ovale
ductus arteriosus
Term
chambers that pump blood into arteries
Definition
r./l. ventricles
Term
chamber with thickest wall
Definition
l. ventricle
Term
why does the l. ventricle have a thick wall
Definition
to contract with the greatest amount of force to create the greatest amount of BP to pump blood all over body
Term
r. ventricle pumps ___ blood to lungs
Definition
deoxygenated
Term
l. ventricle pumps ___ blood to body systems
Definition
oxygenated
Term
pathway r. ventricle to l. atrium
Definition
r. venticle
pulmonary valve
pulmonary trunk
r./l. pulmonary arteries
lungs (gas exchange)
r./l. pulmonary veins
l. atrium
Term
pathway l. ventricle to r. atrium
Definition
l. ventricle
aortic valve
aorta
arteries
arterioles
capillaries (exchange)
venules
veins
SVC/IVC
r. atrium
Term
pathway of blood from RA to RA
Definition
deoxygenated blood drains fom SVC/IVC/coronary sinus to r. atrium through tricuspid AV valve to r. ventricle through pulmonary valve to pulmonary trunk which divides into r./l. pulmonary arteries to lungs for gas exchange

oxygenated blood moves from lungs via r./l. pulmonary veins to l. atrium through bicuspid AV valve to l. ventricle through aortic valve to aorta-arteries-arterioles-capillary beds gas exchange occurs

deoxygenated blood moves into venules-veins-IVC and SVC to r. atrium
Term
internal ridges of muscle in ventricles
Definition
trabeculae carneae
Term
r. and l. ventricle separated by
Definition
interventricular septum
Term
4 valves of heart
Definition
2 atrioventricular valves
r. AV = tricuspid
l. AV = bicuspid/mitral
2 semilunar valves
pulmonary
aortic
Term
incomplete closure of a valve is known as
Definition
heart murmur
Term
heart valves ensure ___ flow
Definition
one-way
Term
heart strings aka
Definition
tendinous chords
Term
connect AV valve cusps to conical papillary muscles on floor of ventricles
Definition
tendinous chords
Term
prevent prolapsing of AV valves into atria during ventricular systole (contraction) and prevent blood from reentering the atria
Definition
tendinous chords
Term
muscular extensions of the inner ventricles
Definition
papillary muscles
Term
contract and regulate tension on tendinous chords to keep AV valves closed in a horizontal position during ventricular systole
Definition
papillary muscles
Term
valve separates r. ventricle from pulmonary trunk
Definition
pulmonary semilunar valve
Term
prevents backflow of blood from the pulmonary trunk into the r. ventricle during ventricular diastole (relaxation)
Definition
pulmonary semilunar valve
Term
valve separates l. ventricle from aorta
Definition
aortic semilunar valve
Term
prevents backflow of blood from the aorta into the l. ventricle during ventricular diastole (relaxation)
Definition
aortic semilunar valve
Term
when ventricles are relaxed ___ are open and ___ are closed to prevent backflow into ventricles
Definition
AV valves
semilunar valves
Term
when ventricles are contracting ___ are closed to prevent backflow into the atria and ___ are open
Definition
AV valves
semilunar
Term
when atrial pressure is greater than ventricular pressure, ___ valves open and blood flows through to ventricles.
Definition
AV
Term
when ventricular pressure rises above atrial pressure, the blood in ventricles pushes ___ valves closed
Definition
AV
Term
when pressure in the ventricles is greater than the pressure in the great arteries, the ___ valves are forced open and blood is ejected into the arteries
Definition
semilunar
Term
when ventricular pressure is lower than BP in the arteries, arterial blood closes ___ valves
Definition
semilunar
Term
true/false the myocardium has its own supply of arteries and capillaries that deliver blood to every cardiocyte
Definition
true
Term
1st arteries off ascending aorta
Definition
r./l. coronary arteries
Term
l. coronary artery (LCA) branches (3)
Definition
1 anterior interventricular branch of LCA
2 circumflex branch of LCA
3 circumflex branch of LCA branches to l. marginal branch of LCA
Term
r. coronary artery (RCA) branches (2)
Definition
1 r. marginal branch of RCA
2 posterior interventricular branch of RCA
Term
when 2 arteries come together and combine their blood flow to points farther downstream
Definition
arterial anastomoses
Term
2 arterial anastomoses of heart
Definition
1 anterior interventricular branch of LCA and posterior interventricular branch of RCA
2 r. coronary a. and circumflex a.
Term
3 reasons for peak flow of blood into coronary arteries occurs when ventricles (heart) relax
Definition
1 contraction of myocardium compresses the coronary a. and obstructs blood flow
2 ventricular systole, aortic valve opened, cusps over openings of coronary a.
3 ventricular diastole, blood flows back to heart, aortic valves close, blood flows into coronary a.
Term
pathway of coronary circulation
Definition
1 r./l. coronary a. branch off ascending aorta and carry oxygenated blood to heart
2 r. coronary a. branches into r. marginal branch of RCA and posterior interventricular branch of RCA
3 l. coronary a. branches into anterior interventricular branch of LCA and circumflex branch of LCA
4 capillaries and gas/nutrient and waste exchange
5 capillaries merge into VENULES which merge into CARDIAC VEINS which merge into CORONARY SINUS which carries deoxygenated blood into R. ATRIUM
Term
means impulse for heartbeat originates in heart
Definition
myogenic
Term
even a solitary, isolated cardiac muscle cells pulsate rhythmically and is said to be
Definition
autorhythmic
Term
heart is mostly muscle made up of ___ which are striated, short, thick branched muscle cells
Definition
cardiocytes
Term
have one nucleus surrounded by glycogen
Definition
cardiocytes
Term
have large mitochondria and T tubules admit Ca from extracellular fluid
Definition
cardiocytes
Term
joined by intercalated discs
Definition
cardiocytes
Term
3 features form intercalated disc
Definition
1 interdigitating folds
2 mechanical junctions
3 electrical junctions
Term
composed of plasma membrane at end of cardiocyte that is folded like bottom of egg carton (1 of the 3 features of intercalated discs)
Definition
interdigitating folds
Term
increase surface area of intracellular contact (1 of the 3 features of intercalated discs)
Definition
interdigitating folds
Term
what are 2 types of mechanical junctions
Definition
fascia adherens
desmosomes
Term
what are actin myofilaments that anchor the cardiocyte together
Definition
fascia adherens
Term
what keeps cardiocyte from pulling apart
Definition
desmosomes
Term
what enables cardiac tissue to resist mechanical stress
Definition
desmosomes
Term
what creates a strong structural network that binds cells together throughout cardiac tissue
Definition
desmosomes
Term
electrical junctions contain ___ junctions
Definition
gap
Term
what forms channels allowing ios to flow from cytoplasm of one cardiocyte directly into the next cardiocyte
Definition
electrical junctions that contain gap junctions
Term
do the atria and ventricles act as single cells and contract together
Definition
yes
Term
what type of -cytes are rich in myoglobin and glycogen and have large mitochondria
Definition
cardiocyte
Term
what type of respiration do cardiocytes carry out? (aerobic or anaerobic)
Definition
aerobic
Term
the cardiac conduction system is composed of what 2 things
Definition
internal pacemaker
nerve-like pathways through the
mitochondria
Term
what generates and conducts rhythmic electrical signals
Definition
cardiac conduction system
Term
cardiac conduction system pathway (5)
Definition
SA node
AV node
AV bundle
Right and Left bundle branches
purkinjie fibers
Term
___ is known as the SA node or pacemaker
Definition
sinoatrial node
Term
what node in the cardiac conduction system is in the right atrium near opening of SVC
Definition
SA node
Term
what node in the cardiac conduction system initiates each heartbeat and determines heart rate
Definition
SA node
Term
does the SA node stimulate both atria
Definition
yes
Term
what is stimulated after the atria contract? (node within cardiac conduction system)
Definition
AV node
Term
what node in the cardiac conduction system is located at the end of the interatrial septum near right AV valve
Definition
AV node
Term
what is the only route to the ventrilces in the cardiac conduction system
Definition
AV node
Term
what node in the cardiac conduction system send impulse to AV bundle
Definition
AV node
Term
what is the electrical connection between the atria and ventricles
Definition
AV bundle
Term
what sends electrical impulse to R/L bundle branches in the cardiac conduction system
Definition
AV bundle
Term
what stimulates the Purkinje fibers in the cardiac conduction system
Definition
R/L bundle branches
Term
what are "nerve-like" fibers that radiate throughtout the ventricles
Definition
Purkinje fibers
Term
what stimulates the cardiocytes of ventricles to contract
Definition
Purkinje fibers
Term
atrial and ventricular cells are connect by ___ so both atria and ventricles contract simultaneously
Definition
intercalated disk
Term
pathway of cardiac conduction (5)
Definition
SA node
AV node
AV bundle
Right and Left bundle branches
Purkinje fibers
Term
does the heart have its own pacemaker
Definition
yes
Term
does the heart receive both sympathetic and parasympathetic nerves that modify heart rate and contraction
Definition
yes
Term
with the sympathetic pathway of the heart, where do the cardiac nerves terminate
Definition
SA & AV nodes
Term
sympathetic stimulation of the heart does what to HR
Definition
increase it
Term
sympathetic stimulation of the heart does what to contraction strength
Definition
increase it
Term
sympathetic stimulation of the heart does what to coronary arteries
Definition
dilates
Term
with the parasympathetic pathway of the heart, where does it begin and terminate
Definition
begins with vagus nerves in medulla oblongata and terminates at the SA & AV nodes
Term
parasympathetic stimulation does what to HR
Definition
reduces
Term
systole =
Definition
contraction
Term
diastole =
Definition
relaxation
Term
normal heartbeat triggered by SA node is called
Definition
sinus rhythm
Term
any region of spontaneous firing other than SA is called
Definition
ectopic focus
Term
when will ectopic focus take over
Definition
if SA node is damaged
Term
most common ectopic focus is
Definition
nodal rhythm
Term
AV node produces slower heartbeat (40-50bpm) is known as
Definition
nodal rhythm
Term
whats needed if neither the SA nor AV node is functioning
Definition
artificial pacemaker
Term
any abnormal cardiac rhythm is
Definition
arrhythmia
Term
whats one cause of arrhytmia
Definition
heart block
Term
2 examples of a heart block (arrythmia)
Definition
bundle branch block
total heart block
Term
failure of any part of conduction system to transmit signals
Definition
heart block
Term
damage to one or both bundle branches
Definition
bundle branch block
Term
in ___, damaged AV node fails to send signals to ventricles (3 words)
Definition
total heart block
Term
in impulse conduction of myocardium, ___ excites atrial cardiocytes which stimulates 2 atria to contract almost simultaneously
Definition
SA node
Term
in impulse conduction of myocardium, SA node signal travels to ___ and signal slows
Definition
AV node
Term
why is there a delay in the impulse conduction to myocardium
Definition
allows time for ventricles to fill
Term
in impulse conduction of myocardium, signals travel through ___ which branches to R/L bundle branches to ___
Definition
AV bundle
Purkinje fibers
Term
in impulse conduction of myocardium, purkinje fibers stimulate ___ to contract an instant before stimulating ventricular contraction
Definition
papillary muscles
Term
in impulse conduction of myocardium, papillary muscles take up slack on the ___ to keep AV valves closed in a horizontal position
Definition
tendinous cords
Term
what is a graph of the hearts electrical activity as expressed in millivolts (mV) over time
Definition
electrocardiogram (ECG, EKG)
Term
what is an instrument that amplifies the signals and produces a record on a moving paper chart
Definition
electrocardiograph
Term
what is the moving paper chart used in an electrocardiograph known as
Definition
electrocardiogram (ECG, EKG)
Term
what 3 principal defections does an EKG show
Definition
P wave
QRS complex
T wave
Term
___ is produced when a signal from SA node spreads through the atria and the atria is depolarized (EKG terms)
Definition
P wave
Term
atrial systole begins after the ___ begins
Definition
P wave
Term
___ is produced when the signal from the AV node spreads through the ventricular myocardium and ventricles depolarize (EKG terms)
Definition
QRS complex
Term
ventricular systole begins shortly after the ___
Definition
QRS complex
Term
___ is generated by ventricular repolarization before ventricular diastole (EKG terms)
Definition
T wave
Term
why dont we see a wave for atrial repolarization
Definition
because it is hidden by QRS wave
Term
whats the diagnostic value of EKG
Definition
for diagnosing abnormalities in conduction pathways, MI, heart enlargement and electrolyte and hormone imbalances
Term
what consist of one complete contraction and relaxation of all 4 chambers
Definition
cardiac cycle
Term
blood flow is governed by 2 main variables
Definition
pressure
resistance
Term
what impels a fluid to move in regards to blood flow
Definition
pressure
Term
what opposes flow in regards to blood flow
Definition
resistance
Term
how is blood pressure expressed - in mm of what
Definition
mercury
Term
how is BP measured
Definition
sphygmomanometer
Term
fluids flow ___ the pressure gradient from ___ pressure to ___ pressure
Definition
down
higher
lower
Term
pressure is ___ proportional to the volume of the container
Definition
inversely
Term
___ is analogous to heart chamber
Definition
syringe barrel
Term
the opening and closing of heart valves are governed by ___
Definition
pressure changes
Term
when left ventricle contracts, internal pressure rises, ___ valve opens. blood is ejected from left ventricle into aorta
Definition
aortic
Term
when left ventricle is expanding, internal pressure falls, left ___ valve opens and blood flows from left atrium into left ventricle.
Definition
AV
Term
heart sounds are audible with a
Definition
stethoscope
Term
listening to sounds made by the body or heart is known as
Definition
auscultation
Term
1st heart sound (s1) = lubb = occurs with closure of
Definition
AV valves
Term
2nd heart sound (s2) = dupp = occurs with closure of
Definition
semilunar valves
Term
3rd heart sound (s3) = can you hear it in children and adolescents
Definition
barely
Term
regurgitation of blood through an incompetent valve is a
Definition
heart murmur
Term
what creates a turbulence that can be heard with a stethoscope
Definition
heart murmur
Term
what does the pause in the heart sounds indicate
Definition
the period when the heart is relaxing during atrial diastole and ventricular diastole
Term
4 phases of cardiac cycle
Definition
ventricular filling
isovolumetric contraction
ventricular ejection
isovolumetric relaxation
Term
how fast is the cardiac cycle
Definition
less than 1 second
Term
what occurs during atrial and ventricular diastole, ventricles expand, BP drops, AV valves open and blow flows in ventricles; P wave occurs, atria depolarizes, atria contracts
Definition
ventricular filling
Term
end of ventricular filling, ventricles contain
Definition
end-diastolic volume EDV
Term
what occurs as atria repolarize, ventricles depolarize, generate QRS complex, ventricles contract, ventricular blood surges on AV valves and AV valves close producing 1st heart sound s1
Definition
isovolumetric contraction
Term
in isovolumetric contraction, is there a change in blood volume in ventricles
Definition
no
Term
in isovolumetric contraction, what valves are closed
Definition
all 4
Term
occurs when ventricular pressure exceds arterial pressure, semilunar valves open, blood spurts out rapidly at first, T wave occurs late in the phase
Definition
ventricular ejection
Term
ventricles do/do not expel all their blood
Definition
do not
Term
amount of blood ejected
Definition
stroke volume
Term
amount of blood remaining in ventricles after ventricular ejection
Definition
end-systolic volume
Term
what is the measure of cardiac health
Definition
ejection fraction
Term
occurs when T wave ends, early ventricular relaxation, ventricles expand, blood in aorta and pul trunk flows backward, semilunar valves close, produce 2nd heart sound S2
Definition
isovolumetric relaxation
Term
when ___ valves open, ventricular filling begins
Definition
AV
Term
true/false equal output by both ventricles is essential to homeostasis
Definition
true
Term
if r. ventricle pumps larger vol of blood to lungs, blood accumulates in the lungs causing 3 things
Definition
pulmonary hypertension
edema
drowning in one's one body fluids
Term
if l. ventricle pumps more than the r. ventricle can take, then blood accumulates in the systemic sys causing
Definition
systemic edema (dropsy)
ascites
Term
pooling of fluid in the abdominal cavity is called
Definition
ascites
Term
fluid accumulation in either circuit due to insufficiency of ventricular pumping is called
Definition
congestive heart failure
Term
amount of blood ejected by each ventricle in one minute
Definition
cardiac output
Term
cardiac output is ___ constant
Definition
not
Term
difference between max CO and resting CO
Definition
cardiac reserve
Term
measured by taking one's pulse and counting heart sounds
Definition
heart rate
Term
persistent HR>100
Definition
tachycardia
Term
persistent HR<60
Definition
bradycardia
Term
factors that increase HR
Definition
positive chronotropic agents
Term
factors that decrease HR
Definition
negative chronotropic agents
Term
ANS does/does not initiate heartbeat
Definition
does not
Term
ANS can/cannot modify hearts rhythm and force
Definition
can
Term
cardiac centers have 2 types of neurons
Definition
cardio-stimulatory
cardio-inhibitory
Term
cardio-stimulatory effect and transmits signals by ___ pathway
Definition
sympathetic
Term
cardio-inhibitory effect and transmits signals by ___ nerve by ___ pathway
Definition
vagus
parasymphathetic
Term
cardio-stimulatory effect releases ___ and accelerates SA nodes which increases HR
Definition
norepinephrine
Term
cardio-inhibitory effect releases ___ and inhibits SA and AV nodes and decreases HR
Definition
acetylcholine
Term
sensory and emotional stimuli can/cannot act on cardiac centers
Definition
can
Term
type of receptor that informs cardiac center about changes in physical activity and HR increases output before metabolic demands of mus rises
Definition
proprioceptors
Term
pressure sensors located in aorta and carotid arteries that continually send signals to cardiac center
Definition
baroreceptor
Term
monitor chemicals and sensitive to blood pH, CO2, O2; located in aortic and carotid bodies
Definition
chemoreceptors
Term
K+ has ____ chronotropic effects on heart
Definition
greatest
Term
4 things that have chronotropic effects and increase HR
Definition
norepinephrine/epinephrine
nicotine
caffeine
Term
in ___ K+ moves into cardiocyte and inhibits repolarization; HR slow and irregular and may lead to heart block/cardiac arrest
Definition
hyperkalemia
Term
in ___, K+ moves out of cardiocyte and hyperpolarizes the membrane making it harder to depolarize and stimulat; heart beats feebly and arrythmically
Definition
hypokalemia
Term
exercise increase/decrease cardiac output
Definition
increase
Term
what can a sustained exercise program cause
Definition
hypertrophy of ventricles
Term
hypertrophy of ventricles ___ stroke volume which allows heart to beat slowly and heart doesnt have to work as hard
Definition
increases
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