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Bio 111
Purdue University Exam 1 Dr. Bos
61
Biology
Undergraduate 1
02/01/2013

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Term
true-breeding
Definition
a genetic cross in which the same result occurs every time with respect to the traits under consideration due to homozygous parents
Term
monohybrid cross
Definition
a mating in which the parents differ with respect to the alleles of only one locus of interest
Term
dihybrid cross
Definition
a mating in which the parents differ with respect to the alleles of two loci of interest
Term
Parental Generation
Definition
the individuals that mate in a genetic cross, their offspring are the first filial generation
Term
First filial generation
Definition
the immediate progeny of the parental mating
Term
Second filial generation
Definition
the immediate progeny of a mating between members of the F1 generation
Term
Alleles
Definition
the alternate form of a genetic character found at a given locus on a chromosome
Term
Homozygous
Definition
in diploid organisms, having identical alleles of a given gene on both homologous chromosomes
Term
heterozygous
Definition
in diploid organisms, having different alleles of a given gene on the pair of homologs carrying that gene
Term
dominant
Definition
the gene that shows
Term
recessive
Definition
the gene that does not show unless there is two of them
Term
test cross
Definition
mating of a dominant-phenotype individual with a homozygous-recessive individual
Term
genotype
Definition
the set of alleles that are possible
Term
phenotype
Definition
the actual characteristics shown by genotypes
Term
principle of segregation
Definition
when any individual produces gametes the two copies of a gene separate so that each gamete receives only one copy, each individual receives two alleles, one from each parent
Term
principle of independent assortment
Definition
alleles of different genes assort independently of one another during gamete formation
Term
Punnett square
Definition
method of predicting genetic crosses by arranging the gametes of each parent at the edges of a square
Term
Product rule
Definition
the overall probability =product of individual probabilities
probAaBbCc= probAa+probBb+probCc
Term
Polygenic inheritance
Definition
some traits vary over a range in different degrees, this is due to the fact that many different genes influence the trait.
Term
Pleiotropy
Definition
a single gene mutation can influence several traits
Term
Incomplete dominance
Definition
heterozygote has intermediate phenotype compared to homozygotes, its the idea of blending but the original phenotypes come back in F2
Term
Codominance
Definition
the heterozygous shows the full phenotypes of both homozygotes
Term
Epistasis
Definition
when the products of different genes interact in a non-additive way with each other to influence phenotype, one gene makes it so the other genes don't show up, mask the other genes
Ex.labs
Term
Linkage
Definition
association between two genes on the same chromosome, when this occurs they no longer show independent assortment, the closer the genes the lower the frequency for recombination
Term
Locus
Definition
a specific location on a chromosome, sometimes synonym for gene
Term
Sex-linkage
Definition
Phenotypes of genes on sex chromosomes are linked with the phenotype of sex, Recessive sex-linked traits are always expressed in heterogametic sex due to the fact that there is nothing to cover it up.
Term
Map unit
Definition
the distance between two genes as calculated from genetic crosses, a recombination frequency converted to a percentage
1 map unit = 1% recombination = 1 cM
Term
Autosomes
Definition
any chromosome that is not a sex chromosome
Term
Sex chromosomes
Definition
the chromosomes involved in sex determination
Term
Recombination frequency
Definition
The proportion of offspring of a genetic cross that have phenotypes that are different from their parents due to crossing over between linked genes during gamete formation
RF = recombinant progeny/ total progeny
Term
Genetic mapping
Definition
the positions of genes along a chromosome as revealed by recombination frequencies
Term
Binary fission
Definition
replication begins at the origin and then goes both directions, segregation begins at the origin while replication is still occurring,
Term
Chiasmata
Definition
x-shaped connection between homologous chromosomes in prophase I of meiosis, the visible crossing over between homologous chromosomes
Term
Crossing over
Definition
the way that linked genes go through recombination. exchange of corresponding segments between two homologous chromosomes
Term
Synaptonemal complex
Definition
a protein structure that forms between homologous chromosomes during meiosis and mediates chromosome pairing
Term
Synapsis
Definition
the highly specific parallel alignment of homologous chromosomes during the first division of meiosis
Term
Germ-line cells
Definition
the cells such as gametes that are involved in reproduction
Term
Somatic cells
Definition
all cells not involved in the reproduction
Term
Tumor suppressor gene
Definition
slow/inhibit cyclin production, cell growth and division rates, leads to tumor growth
Term
Oncogene
Definition
are mutated, abnormal proto-oncogenes that are overactive
Term
Proto-oncogene
Definition
normal signals that stimulate cyclin production and cell division
Term
Separase
Definition
cuts proteins
Term
Anaphase promoting complex (APC)
Definition
destroys the cyclins so the cells can enter G0
Term
Cyclin-dependent kinase (Cdk)
Definition
help regulate the cell cycle
Term
Origin of replication
Definition
where the replication starts during binary fission
Term
Terminus
Definition
where binary fission ends.
Term
Septum
Definition
where the two cells pinch apart in binary fusion
Term
Chromatid, sister chromatid
Definition
a newly replicated chromosome, from the time molecular duplication occurs until the time of centromeres separate
Term
Diploid
Definition
having a chromosome complement consisting of two copies of each chromosome
Term
Kinetochore
Definition
the structure on the centromere where the microtubules attach
Term
Centromere
Definition
the region where centromeres join
Term
Histone
Definition
any one of a group of proteins forming the core of a nucleosome, the structural unit of a eukaryotic chromosome
Term
Nucleosome
Definition
make up the chromosome, DNA wrapped around histones
Term
Solenoid; 30nm fiber
Definition
Term
Haploid
Definition
having a chromosome complement consisting of just one copy of each chromosome
Term
cell cycle checkpoint
Definition
points of transition between different phases of the cell cycle, these are regulated by cyclins and cyclin dependent kinases
Term
cyclin
Definition
they make the transitions happen in a cell cycle, they are proteins that activate cyclin dependent kinase
Term
phosphorylation
Definition
addition of a phosphate group
Term
cell plate
Definition
cytokinesis of plants
Term
contractile ring
Definition
cytokinesis of animals
Term
chromatin
Definition
makes up eukaryotic chromosome
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