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Autonomic Nervous System
Lecture 1
12
Pharmacology
Undergraduate 4
02/14/2011

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Term
Sympathetic
essential? functions?
Definition
not essential
functions as a unit
Term
Parasympathetic
essential? functions?
Definition
essential
functions as individual systems
Term
Sympathetic Neurons
Definition
synapse on ganglia near spinal cord
synapse on adrenal medulla
synapse with several organs
Term
Parasympathetic Neurons
Definition
synapse on ganglia near organ
synapse with single organ
Term
Sympathetic Effects
Definition
Increase heart rate and contractility
Dilates blood vessels
Dilates pupils
Dilates bronchioles
Stimulates sweating
Term
Parasympathetic Effects
Definition
Increase GI motility and tone
Contraction of detrusor
Relax sphincters
Watery saliva
Stimulates tears
Term
Vascular innervation by?
Definition
Sympathetic ONLY
Term
Cholinergic Receptors
Definition
Ligand = Ach
Nicotinic - Ion gated (Nn, Nm)
Muscarinic - GPCR (M1, M2, M3, M4, M5)
Term
Adrenergic Receptors
Definition
Ligand = norepinephrine, epinephrine
Alpha - GPCR (a1, a2)
Beta - GPCR (b1, b2)
Term
Sympathetic Diagram
Definition
Preganglionic releases Ach
Ach binds Nicotinic receptor (on postgang. or Ad.Med.)
Postganglionic/Ad.Med. releases NE/epi
NE/epi binds adrenergic receptor on organ
Term
Parasympathetic Diagram
Definition
Preganglionic releases Ach
Ach binds Nicotinic receptor (on postganglionic)
Postganglionic releases Ach
Ach binds muscarinic receptor on organ
Term
Somatic Diagram
Definition
(no ganglia)
Neuron releases Ach
Ach binds nicotinic receptor (on skeletal muscles)
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