Term
| Arteriviridae Characteristics |
|
Definition
enveloped, ssRNA, positive sense
short incubation period |
|
|
Term
| Arteriviridae Entry, Replication, Release |
|
Definition
receptor mediated endocytosis
replicates in cytoplasm
shuts off cellular biosynthesis and buds from internal organelles
cytolysis |
|
|
Term
|
Definition
macrophages/monocytes
persistent infection |
|
|
Term
| Arteriviridae Pathogenesis |
|
Definition
primary replication in alveolar macrophages
infection in lymphoid tissue
viremia and systemic spread
persistent infections |
|
|
Term
| Arteriviridae Transmission |
|
Definition
respiratory
contact with aborted fetus/tissue
transplacental and semen |
|
|
Term
| Equine Arteritis Virus Signs |
|
Definition
subclinical to acute systemic febrile disease
50-60% of mares abort
stallions are carriers in ampulla (gets in semen)
vasculitis, edema scrotum, ocular) |
|
|
Term
| Equine Arteritis Virus Pathogenesis |
|
Definition
primary replication in alveolar macrophages
infection of lymphoid tissue
viremia in monocytes and endothelium |
|
|
Term
| Equine Arteritis Virus Tropism |
|
Definition
|
|
Term
| Equine Arteritis Virus Transmission |
|
Definition
respiratory
contact with aborted tissues
semen
transplacental |
|
|
Term
| Equine Arteritis Virus Control |
|
Definition
MLV vaccine for valuable breeding mares
idenfity persistently infected stallions
only breed to anti-EAV antibody positive mares |
|
|
Term
| Porcine Reproductive and Respiratory Syndrome Tropism |
|
Definition
alveolar macrophages
germ cells (testes) |
|
|
Term
| Porcine Reproductive and Respiratory Syndrome Transmission |
|
Definition
respiratory
contact with aborted tissues
transplacental
semen |
|
|
Term
| Porcine Reproductive and Respiratory Syndrome Pathogenesis |
|
Definition
primary replication in macrophages
infection of lymphoid tissue
virema (0-3 weeks pi)
viral persistence in alveolar macrophages up to 8 weeks pi
viral persistence in other tissues |
|
|
Term
| Porcine Reproductive and Respiratory Syndrome Signs |
|
Definition
respiratory disease
infertility
late-term abortions
still births
prolonged gestation
high morbidity and mortality |
|
|
Term
| Porcine Reproductive and Respiratory Syndrome Control |
|
Definition
| vaccination with herd specific vaccine |
|
|
