Term
|
Definition
|
|
Term
|
Definition
weak anti inflamm
weak inhib of COX
Anti inflamm only at high dose |
|
|
Term
|
Definition
No gastric irritant
No effect on platelet coag |
|
|
Term
|
Definition
90% glucuronidation and sulfation
5% CYP450 to NAPQI |
|
|
Term
| children w/toxicity to apap |
|
Definition
| they have more sulfation capacity making them less predisposed to toxicity |
|
|
Term
| how does long term use of ethanol exacerbate apap toxicity? Short term? |
|
Definition
induces CYP2E1
decreases toxicity by reducing NAPQI |
|
|
Term
|
Definition
max 24 hours
nausea, vomiting
asymptomatic |
|
|
Term
|
Definition
1-3 days
abdominal tenderness
clotting factors may be altered
renal involvement |
|
|
Term
|
Definition
3-9 days
hepatic injury
death from multi organ failure |
|
|
Term
|
Definition
4-14 days
resolution of liver failure and lack of liver fibrosis |
|
|
Term
| traditional treatment protocol in US |
|
Definition
| 72 hour regimen of oral NAC |
|
|
Term
| Other aspects of treatment overdose |
|
Definition
activated charcoal
anti emetic therapy |
|
|
