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| Black Death introduced to Italy via ships from the East. |
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| End of Hundred Years' War; Constantinople falls to the Ottomans. |
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| Moors and Jews expelled from Spain; Columbus sails to the Americas. |
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| Martin Luther posts his Ninety Five Theses in Wittenberg. |
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| Sack of Rome ends Renaissance. |
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| Act of Supremacy establishes the Church of England/Anglican Church. |
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| Peace of Augsburg allows Lutheranism in Holy Roman Empire. |
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| St, Bartholomew's Day Massacre begins the Wars of Religion in France. |
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| The Spanish Armada is defeated. |
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| Edict of Nantes ends French Wars of Religion |
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| English Civil War begins. |
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| Treaty of Westphalia ends Thirty Years' War. |
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| Ottoman Turks reach high water mark in Vienna. |
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| Newton publishes Principia Mathematica. |
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| Glorious Revolution in England. |
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| Peace of Utrecht ends Spanish War of Succession. |
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