Term
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Definition
Mech: blocks viral penetration/uncoating (M2 protein); causes DA release
Use: prophyl for influenza A; rubella; Parkinson's dz
Tox: cerebellar tox (ataxia, dizzy, slurred speech)
Note: 90% of flu has resistant M2
"a man ta dine take off coat" |
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Term
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Definition
Mech: blocks viral penetration/uncoating (M2 protein)
Use: prophyl for influenza A; rubella
Tox: fewer CNS SE than amantadine (doesn't cross BBB)
Note: 90% of flu has resistant M2 |
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Term
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Definition
Mech: inhibs flu neuraminidase → decr. release of progeny
Use: influenza A & B |
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Term
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Definition
Mech: inhibs flu neuraminidase → decr. release of progeny
Use: influenza A & B
Note = Tamiflu |
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Term
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Definition
Mech: competitively inhibs IMP DH → inhibs G synth
Use: RSV, chronic <strong>HCV</strong>
Tox: hemolytic anemia, severe teratogen (contra: preg) |
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Term
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Definition
Guanosine analog
Mech: mono-P by HSV ThyKinase → tri-P by cellular Es → inhibs (preferentially viral) DNApol (chain terminator)
Use: HSV, VZV (famcyclovir for HSV), EBV; prophyl in ImuunoComp
Tox: crystalline nephrotox. (prevent w/ aggressive hydration)
Note: no effect on latent HSV/VZV |
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Term
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Definition
G analog
Mech: mono-P from CMV kinase or HSV/VZV TK → tri-P by cellular Es → inhibs (pref viral) DNApol
Use: <strong>CMV </strong>(esp immuno comp)
Tox: leukopenia, neutropenia, thrombocytopenia, renal tox (greater tox than acyclovir) |
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Term
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Definition
Pyrophosphate analog
Mech: binds DNApol (does not req activation)
Use: gancic-<strong>resist</strong> CMV retinitis; acyc-resist HSV
Tox: chelates Ca; renal Mg wasting → decr. Mg → decr. PTH release → further decr. Ca; low Mg & Ca → seizures
"FOScarnet = pyroFOSphate" |
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Term
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Definition
HIV protease inhib;
others(..navir)-ritonavir, indinavir, nelfinavir, amprenavir
Mech: inhibs maturation of new virus
Tox: GI, hyperglycemia, lipodystrophy, thrombocytopenia (indinavir)
"NAVIR TEASE a proTEASE" |
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Term
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Definition
HIV protease inhib;
others(..navir)-saquinavir, indinavir, nelfinavir, amprenavir
Mech: inhibs maturation of new virus
Tox: GI, hyperglycemia, lipodystrophy, thrombocytopenia (indinavir)
"NAVIR TEASE a proTEASE" |
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Term
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Definition
HIV NRTI
Use: 2 NRTIs combo w/ PI for HAART when CD4<500;
general prophyl during preg
Tox: <em>marrow suppr</em>, periph neuropathy, lactic acidosis, megaloblastic anemia |
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Term
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Definition
HIV NRTI
Use: 2 NRTIs combo w/ PI for HAART when CD4<500;
general prophyl during preg
Tox: marrow suppr, periph neuropathy, lactic acidosis |
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Term
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Definition
HIV NRTI
Use: 2 NRTIs combo w/ PI for HAART when CD4<500;
general prophyl during preg
Tox: marrow suppr, periph neuropathy, lactic acidosis |
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Term
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Definition
HIV NRTI
Use: 2 NRTIs combo w/ PI for HAART when CD4<500;
general prophyl during preg
Tox: marrow suppr, periph neuropathy, lactic acidosis |
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Term
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Definition
HIV NNRTI (non-nucleoside RT inhib)
Mech: bind revers transcript (site diff from NRTI)
Use: combo w/ 2NRTIs for HAART when CD4<500;
No Phosphorylation req for activity
Tox: marrow suppr, periph neuropathy, rash
"Never Ever Delavir nucleosides" |
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Term
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Definition
HIV NNRTI (non-nucleoside RT inhib)
Mech: bind revers transcript (site diff from NRTI)
Use: combo w/ 2NRTIs for HAART when CD4<500;
No Phosphorylation req for activity
Tox: marrow suppr, periph neuropathy, rash
"Never Ever Delavir nucleosides" |
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Term
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Definition
HIV NNRTI (non-nucleoside RT inhib)
Mech: bind revers transcript (site diff from NRTI)
Use: combo w/ 2NRTIs for HAART when CD4<500;
No Phosphorylation req for activity
Tox: marrow suppr, periph neuropathy, rash
"Never Ever Delavir nucleosides" |
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Term
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Definition
HIV fusion inhibitor
Mech: binds gp41 (inhib fusion w/ CD4s)
Use: salvage regimen when other HIV drugs not sufficient
Tox: hypersens, injection site rxns, risk of bacterial pneum |
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Term
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Definition
Mech: block stages of viral RNA/DNA synth; induce ribonuclease to degrade viral mRNA
Use: chronic HBV/HCV, Kaposi's sarcoma, leukemias, malignant melanoma
Tox: neutropenia |
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Term
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Definition
Use: Multiple Sclerosis
Tox: neutropenia |
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Term
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Definition
Use: NADPH oxidase deficiency; (chronic granulomatous dz)
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