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Antioncogenes (TSGs)
page 13
8
Medical
Pre-School
07/11/2012

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Cards

Term
located on chromosome 13
Definition
Retinoblastoma
Term
normal gene product prevents cell from entering S cycle
Definition
Retinoblastoma
Term
Mutations seen in osteosarcoma, Ca *breast, colon, and lung*
Definition
Retinoblastom
Term
Mutations seen in many cancers including leukemias, sarcomas, Ca breast, brain
Definition
Gene TP53
Term
Role in DNA Repar and about 10% of breast cancers also Ca ovary
Definition
BRCA-1 BRCA-2
Term
Cell regulator gene mutants associated w/ adenomatous polyps of colon and Ca Colon
Definition
APC gene
Term
one of the guardian genes "new guardian"
Definition
PTEN
Term
old guardian
Definition
p53
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