Term
What is the Antimaniac drug used?
MOA? |
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Definition
Lithium
- stops the recycling of PIP2, thus reducing the the second messenger effects of IP3-DAG (PLC) |
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Term
| What are the uses of lithium? |
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Definition
Acute mania & BPD - Lithium along with carbamazepine & valporate/valporic acid
Prophylaxis 0f BPD - Lithium + TCA |
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Term
| What are the ADR's associated with lithium? |
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Definition
- Nausea,
- Vomiting,
- Fine tremors
- Nephrogenic diabetes insipidus (Collecting Ducts become unresponsive to ADH- polydipsia, polyuria- Tx- Amiloride
- Hypothyroidism
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Term
| How is Nephrogenic DI caused by lithium treated? |
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Definition
- polyuria, polydipsia
Amiloride |
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