Term
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Definition
HMG-CoA reductase inhibitors:
Most effect comes from Hepatic uptake of LDL in response to inability to synthesize it.
Number one antihyperlipidemic (LDL mainly followed by VLDL)
Rosuvastatin>Atorvastatin>Simvastatin
Also works as an antioxidant/antinflammatory
DO NOT GIVE PREGNANT WOMEN
May cause rhabdomylysis
Modest Hepatoxicity
Moderate increase in Type II diabetes
Big risk factor is CYP450 inhibitors such as anti-HIV drugs
OAT1b1 polymorphism increases blood lvls and rhabdomylysis/K increase |
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Term
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Definition
Anion exchange resin that acts as a bile acid sequesterant
Decreases LDL INCREASES VLDL
2nd-line use hypercholesterolemia
Reduces Hemoglobin H1AC
Stops absorbtion WARFARIN,DIGOXIN,CONTRACEPTIVES |
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Term
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Definition
Stops absorbtion of cholesterol by the NewMann-Pick C1-Like Receptor
used 2nd-line w/statins to reduce LDL
undergoes many cycles of enterohepatic recycling (glucuronidation in liver)
Doesnt reduce size of atheroschlerotic plaque |
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Term
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Definition
PPAR-alpha agonist decreasing triglyceride synthesis and increasing removal
LIVER: increase oxidation of fatty acids, decrease ApoC synthesis
MUSCLE: increase LPL
INCREASES HLD, and DROPS VLDL THEREFORE USE ATHEROGENIC DYLIPIDEMIA
(diabetics with retinopathy)
Cause myopathy with statins
may increase gallstones and PE |
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Term
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Definition
Nicotinic Acid:
BEST INCREASE HDL decrease VLDL
(decreases triglyceride synthesis increases muscle VLDL metabolism)
Can act as a GI IRRITANT, CAUSE FLUSHING (give aspirin), AGGREVATE GOUT AND DIABETES |
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Term
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Definition
| Bile acid sequesterant only one considered somewhat safe |
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