Term
| Cardiac functions is dependent upon adequate amounts of |
|
Definition
ATP
Ca
With a coordinated electrical stimulus |
|
|
Term
| Adequate amounts of ATP are needed to |
|
Definition
Maintain electrochemical gradients
Initiate action potential
power muscle contraction |
|
|
Term
| Adequate amounts of Ca(calcium) are needed to |
|
Definition
^strength of contraction
Enhance automaticity
Vasoconstricts coronary arteries and peripheral arterioles
Glue that links electrical and mechanical events |
|
|
Term
| 2 types of myocardial tissue |
|
Definition
|
|
Term
| Two types of action potentials found in myocardial tissue |
|
Definition
Fast potentials
Slow potentials |
|
|
Term
| Fast potentials are found in what tissue |
|
Definition
|
|
Term
| Contractile tissue is dependent on what ions |
|
Definition
|
|
Term
| Slow potentials are found in what tissues |
|
Definition
|
|
Term
| SA and AV node tissues depend on what |
|
Definition
|
|
Term
Concerning Dysrhythmia generation:
Abnormal Genesis deals with what |
|
Definition
Imbalance of the ANS stimuli
Pathologic depolarization |
|
|
Term
Concerning Dysrhythmia generation:
What are/is Pathologic depolarization |
|
Definition
Ectopic foci
PVC's, PJC's, PAC's |
|
|
Term
All antidysrhythmics have arrhythmogenic properties
what does this mean |
|
Definition
| They can cause dysrhythmias too |
|
|
Term
| What are the AHA recommendation classifications for Cardiacvascular Care |
|
Definition
| Class I, class IIa, Class IIb, class III, and indeterminate |
|
|
Term
| What are the AHA recommendation classifications for Cardiovascular Care |
|
Definition
| Class I, class IIa, Class IIb, class III, and indeterminate |
|
|
Term
| What do AHA Cardiovascular classifications mean |
|
Definition
based on supporting evidence:
I- clear benefit, should perform
IIa- probably helpful, reasonable to perform
IIb- risk=to benefit, may be considered
III- not helpful, probably harmful
indeterminant |
|
|
Term
| Vaughn-Williams Classification of Cardiovascular Drugs |
|
Definition
Based on mechanism not evidence
Class I, Ia, Ib, Ic, II, III, IV, and MISC. |
|
|
Term
| VW(Vaughn Williams) Class I drugs are |
|
Definition
|
|
Term
| What do Class Ia,Ib,Ic NA channel blockers do what |
|
Definition
v NA movement
v conduction and repolarization rate
v excitability
Indications: ventricular dysrhythmias |
|
|
Term
|
Definition
slow conduction through ventricles
Decrease repolarization rate |
|
|
Term
| How do Class IA agents v repolarization rate |
|
Definition
Widen QRS and QT intervals
May propmote Torsades des pointes |
|
|
Term
| What are some Class Ia agents |
|
Definition
PDQ:
procainamide
disopyramide
qunidine |
|
|
Term
|
Definition
Slow conduction through ventricles
^ V-fib threshold
Reduce automaticity
May be used for seizures and ICP |
|
|
Term
| IB agents reduce automaticity how |
|
Definition
| Effective for ectopic foci |
|
|
Term
| What are some Class Ib drugs |
|
Definition
LTMD:
Lidocaine
Tocainide
mexaletine
phenytoin |
|
|
Term
|
Definition
Slow conduction through ventricles,atria,and conduction system
v repolarization
v contractility
Rare last chance drug |
|
|
Term
| What are some Class Ic drugs |
|
Definition
|
|
Term
|
Definition
| Potassium Channel Blockers |
|
|
Term
| What do Potassium channel blockers do |
|
Definition
v K+ efflux during repolarization
Prolongs repolarization which extends effective refractory period
Prototype was bretyllium |
|
|
Term
| What is the prototype for Potassium channel blockers |
|
Definition
|
|
Term
| What are the Contra-indications for Class Ia,Ib,Ic and Class III channel blockers |
|
Definition
| 2nd and 3rd degree Heart Blocks |
|
|
Term
| procainamide is what class of drug |
|
Definition
Class IA- Sodium channel Blocker
Antidysrhythmic |
|
|
Term
|
Definition
|
|
Term
|
Definition
Slows conduction of heart
Suppress ventricular ectopy by reducing automaticity and ^the refractory period
^ QRS and QT width |
|
|
Term
| procainamide (Pronestyl) indications |
|
Definition
All dysrhythmias:
SVT, PSVT, A-fib, A-flutter, V-tach, V-fib |
|
|
Term
|
Definition
|
|
Term
| lidocaine is what class of drug |
|
Definition
Class IB- Sodium channel blocker
Antidysrhythmic |
|
|
Term
|
Definition
Suppress ventricular ectopy dysrhythmias
^ V-fib threshold
v automaticity |
|
|
Term
|
Definition
Ventricular dysrhythmias including
V-tach
V-fib
PVC's |
|
|
Term
| phenytoin is what class of drug |
|
Definition
Class IB Sodium channel blocker
Antiarrhythmic |
|
|
Term
|
Definition
|
|
Term
| phenytoin(Dilantin-tm) MOA |
|
Definition
^ Ventricular threshold
Prolongs refractory period |
|
|
Term
|
Definition
| Arrhythmias caused by digitalis toxicity |
|
|
Term
| What class of Antidysrhythmics do we not care about |
|
Definition
| Class IC Sodium channel blockers |
|
|
Term
| What are class III Antidysrhythmics |
|
Definition
| Potassium channel blockers (K+) |
|
|
Term
| amiodarone is what class of drug |
|
Definition
Class III Potassium channel blocker
Antidysrhythmic |
|
|
Term
|
Definition
|
|
Term
| amiodarone (Cordarone-tm) MOA |
|
Definition
| Prolongs duration of action potential and refractory period without significantly effecting resting potential; relaxes smooth muscles causing vasodilation especially in coronary arteries. Anti-anginal and sympatholytic properties |
|
|
Term
|
Definition
All tachydisrhythmias Pulseless V-tach / V-fib, SVT, atrial fibrillation, atrial flutter, junctional tachycardia and atrial tachycardias,ventricular tachycardia & wide complex tachycardia of unknown origin;
treatment of non-exertional angina |
|
|
Term
| bretylium is what class of drug |
|
Definition
Class III Potassium channel blocker
Antidysrhythmic |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Suppresses re-entry of dysrhythmias by prolonging the depolarization period and the refractory period |
|
|
Term
|
Definition
| Refractory V-fib and V- tach |
|
|
Term
| Does bretylium have any Contra indications |
|
Definition
| None in life threatening situations |
|
|
