Term
|
Definition
Nardil
MAO-I
Serotonin syndrome if taken with SSRIs or similar
Hypertensive crisis if taken with tyramine |
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Term
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Definition
Parnate
Amphetamine-like properties
MAO-I
Serotonin syndrome if taken with SSRIs or similar
Hypertensive crisis if taken with tyramine |
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Term
|
Definition
"Marplan"
MAO-I
Serotonin syndrome if taken with SSRIs or similar
Hypertensive crisis if taken with tyramine |
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Term
|
Definition
Used in Parkinson's
Transdermal form available
MAO-I
Serotonin syndrome if taken with SSRIs or similar
Hypertensive crisis if taken with tyramine |
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Term
|
Definition
Inhibit monomine oxidase enzyme inhibitors
stops metabolism of 5-HT, NE, and DA |
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Term
|
Definition
GI distress
ortho hypotension
sleep disturbance
dry mouth
headache |
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Term
|
Definition
Serotonin syndrome--flushing diaphoresis, myclonic jerks
hypertensive crisis |
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Term
|
Definition
anti-HAM
antihistaminergic--sedation
antiadrenergic--ortho hypo, tachycardia, arrhythmias
antimuscarini--dry mouth, constipation, urinary retention, blurred vision, tacky
Weight gain |
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Term
|
Definition
CI if pre-existing cardiac conduction abnormalities
Lethal in overdose--widened QRS, prolonged QT to torsades to V fib |
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Term
| Treat tricyclic cardiac overdose |
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Definition
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Term
|
Definition
"Pamelor"
least likely to cause ortho hypo |
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Term
|
Definition
"Norpramin"
Least sedating
fewest anticholinergic SEs |
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Term
|
Definition
"Anafranil"
Most 5HT specific
Used for OCD |
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|
Term
Amitriptyline
(also Imipramine and doxepin) |
|
Definition
"Elavil"
used for chronic pain and headaches |
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Term
|
Definition
| 5HT and NE reuptake inhibitor |
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Term
|
Definition
Sexual dysfunction,
GI upset
headache
overall low SE incidence |
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Term
|
Definition
"Prozac"
Relatively activating
very long half life--no need to taper, give if variable compliance
-dirtiest SSRI
-Sexual dysfunction
Can worsen anxiety |
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Term
|
Definition
"Paxil"
Relatively sedating
used in anxiety disorders
Short half life--sig discontinuation syndrome; cannot miss dose |
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Term
|
Definition
"Zoloft"
few drug-drug interaction;often used with ill and elderly
-also used in anxiety disorders
-GI upset for a couple weeks
-relatively short half life--discont syndrome |
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Term
|
Definition
"Celexa"
"Lexapro"
few drug drug interaction
-very low incidence of SEs
for celexa: QT prolongation, keep <40 or <20 with geriatrics |
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Term
|
Definition
"Luvox"
Primarily used in anxiety disorders: OCD, Social, PTSD)
Only approved for OCD
-BID dosing
-very short half life-discont syndrome |
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Term
|
Definition
Similar to SSRIs, thought to be slightly more activating
Sexual dysfunction,
GI upset
headache |
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Term
|
Definition
"Effexor"
SNRI
Potentially helps with chronic pain
CI in Pts with bad HTN, increase systolic 15
-very short half life--signigicant withdrawal syndrome |
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Term
|
Definition
"Cymbalta"
SNRI
potentially helps with DM neuropathic pain
-very expensive
-can cause signifiicant nausea |
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Term
|
Definition
"Wellbutrin"
inhibits reuptake of NE and DA |
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Term
|
Definition
"Wellbutrin"
-fewer sexual side effects
-relatively activating
-help in smoking cessation
-can worsen anxiety
-lowers seizure threshold; CI in pts with eating disorder or epilepsy |
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Term
|
Definition
Remeron
5HT2a/c
5-HT3a antagonist |
|
|
Term
|
Definition
"Remeron"
-appetite stimulation
-sleep aid at low dose
-can lead to weight gain
higher dose better for depression worse for sleep/appetite |
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