Term
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Definition
Amitryptyline(3o)->nortriptyline(2o)
Imipramine(3o)->desipramine(2o)
MOA: 5-HT and NE reuptake inhibitor
2o better at 5HT, 3o better at NE blockade
3o less antiACh effects
SE: Inhibits mAChR, Histamine, a1R
Dry mouth, GI upset, constipation, tachycard, urinary retention. Prolong QTc.
SUICIDE ATTEMPTS -> mydriasis, dry skin, arrhythmias, coma
Tx: ABC, charcoal
Other uses: Migraine prevention, FM, neuropathic pain, insomnia (amitryp), enuresis (imip), panic/anxiety |
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Term
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Definition
Escitalopram, fluoxetine, paroxetine, sertraline
MOA: SSRI, few extra 5HT effects
SE: Nausea, diarrhea, nervousness, insomnia, dec. libido, impotence, INC SUICIDE YOUTH, 5HT syndrome
Fluox and Parox inhibit CYP450 |
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Term
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Definition
Venlafaxine (5HT>epi), duloxetine(5HT=epi)
SE: NOT CYP450 inh.
Nausea, dry mouth, const., insomnia, dizziness, sexual dysfunction. SUICIDE YOUTH. 5HT syndrome
Other uses: Dulox: FM, neuropathic pain
anxiety/panic |
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Term
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Definition
MOA: ??? Weakly NE, DA reuptake inh.
Use: Wellbutrin=zyban=buproprion tobacco abuse
SE: Lower seizure thresh. Suicide youth, headache, nausea, tachycardia, dry mouth, sweating, tremor |
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Term
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Definition
MOA: a2R blocker, 5HT2/3R blocker, antihistamine (few antiACh)
Use: Depression w/ weight loss
SE: Good for older dementia. Sedation, appetite/weight gain. Antiemetic, antipruritic |
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Term
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Definition
5HT reuptake inh. Anti5HT1 receptor, anti 5HT2 receptor
SE: sedation, ortho hypotsn, nausea, headache, dizziness
Use: Depression w insomnia |
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Term
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Definition
MOA: ???
Use: bipolar
SE: polydipsia/uria, renal tox, ataxia, confusion, tremors, leukocytosis, TERATOGEN. CHECK plasma lvl, THYROID, electrolytes
Excretion: urine, inh. by thiazides. eat Na-> excrete Li
Overdose: eat Na, ABCs, dialysis |
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Term
| AEDs and Antipsychotics for Bipolar |
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Definition
Valproate, lamotrigine
Paliperidone, quetiapine, risperidone, ziprasidone, olanzapine, aripirazole, |
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Term
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Definition
MAOI
MOA: Irreversible inhibition of MAO-A
MAO-B has little effect on depression
SE: Serotonin syndrome, hypertensive crisis, SUICIDE YOUTH. anxiety, headache, gi upset, dry mouth |
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