Term
|
Definition
Tricyclic
Produces a balanced NE and 5-HT effect
Also blocks H1, alpha, and muscarinic receptors.
Adv effects include sedation, anticholinergic effects and cardiotoxicity. Narrow therapeutic index. |
|
|
Term
|
Definition
Tricyclic
Also blocks H1, alpha, and muscarinic receptors
Slightly more 5-HT than NE increase
Adv effect: sedation, anticholinergic effects, and cardiotoxicity. Narrow therapeutic index |
|
|
Term
|
Definition
Tricyclic
Much higher 5-HT than NE increase, also blocks alpha, H1, and muscarinic receptors
Adv effects of sedation, anticholinergic effects, and cardiotoxicity. Narrow therapeutic index |
|
|
Term
|
Definition
MAOI, Non-selective
Adv effects of insomnia, tyramine interaction (causes hypertensive crisis), weight gain, and drug interactions |
|
|
Term
|
Definition
MAOI, selective at lower doses for MAO-B. Patch inhibits both in the CNS only (avoids hypertensive crisis)
Adv effects of insomnia, weight gain, and drug interactions. Avoids tyramine interaction. |
|
|
Term
|
Definition
SSRI
Adv effects of insomnia, sexual dysfxn (higher than others), GI disturbances, and serotonin syndrome. Also P450 inhibition |
|
|
Term
|
Definition
SSRI
Adv effects of insomnia, GI disturbances, sexual dysfxn, serotonin syndrome, and P450 inhibition |
|
|
Term
|
Definition
SSRI, excellent efficacy and well tolerated
Adv effects of insomnia, GI disturbances, sexual dysfxn, and serotonin syndrome |
|
|
Term
|
Definition
SSRI. Excellent efficacy and well tolerated
Adv effects of insomnia, GI disturbances, sexual dysfxn, and serotonin syndrome |
|
|
Term
|
Definition
SNRI. Also can be used to treat back pain and osteoarthritis pain.
Adv effects of insomnia, GI disturbances, sexual dysfxn, HTN, and serotonin syntdrome |
|
|
Term
|
Definition
SNRI, good efficacy. Also can treat back pain and osteoarthritis
Adv effects of insomnia, HTN, GI disturbances, sexual dysfxn, P450 block, and serotonin syndrome |
|
|
Term
|
Definition
SNRI, also can treat fibromyalgia and neuropathic pain.
Adv effects of insomnia, HTN, GI disturbances, sexual dysfxn, and serotonin syndrome. No P450 inhibition. |
|
|
Term
|
Definition
| Atypical antidepressant, inhibits reuptake of serotonin |
|
|
Term
|
Definition
Atypical antidepressant, DA and NE reuptake inhibitor. Good for severe depression with loss of interest. Safe for cardiac Pt and no sexual side effects.
Also can be used to help quit smoking. |
|
|
Term
|
Definition
Atypical antidepressant, blocks presynaptic alpha 2 receptors leading to incr 5-HT and NE. Also blocks 5-HT autoreceptors leading to incr release of serotonin.
Minimal effects on CYP450 enz and can also be used as anti-nausea. |
|
|
Term
|
Definition
| Atypical antidepressant, inhibits 5-HT2C autoreceptors leading to incr release of serotonin and NE. Also restores circadian rhythm and sleep quality. Not yet approved. |
|
|
