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block reuptake of NA and 5HT. they also have anticholinergic effects
tri-c's: convulsions, coma, cardiotoxicity (arrythmias). treat with NaHCO3 for cardiotoxicity |
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| Noradrenergic specific reuptake side effects |
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tremors
tachycardia
sweating
insomnia
erectile and ejaculatory problems |
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| dopaminergic reuptake inhibition side effects |
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psychomotor activation
aggravation of psychosis |
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| 5HT reuptake inhibition side effects |
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GI distress
nausea
headache
nervousness
akathisia
sexual side effects
anorexia |
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| muscarinic antagonism side effects |
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blurred vision
dry mouth
impaired memory
constipation
urinary retention |
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| alpha andrenergic antagonism side effects |
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orthostatic hypotension, dizziness
reflex tachycardia |
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| dopaminergic D2 antagonism side effects |
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extrapyramidal movement disorders
endocrine changes
sexual dysfunction |
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| 5HT2 antagonism side effects |
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| histaminergic H1 antagonism side effects |
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sedation, drowsiness
weight gain
hypotension |
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unipolar depression
anti panic & anxiolytic
chronic pain
insomnia
be careful because the anticholinergic effects and cardiotoxicity! can also cause weight gain
OD is easy, 3-5x daily dose |
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| don't take decongestants, stimulants, demerol (meperidine) or anesthetics with these drugs: interactions can be lethal |
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use these drugs for:
depression
anxiety disorders
eating disorders
pmdd
ocd |
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SSRIs
they have few side effects: nervousness, insomnia, GI stuff, sexual dysfunction, headaches, myoclonus |
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this NDRI AD is nice because it has no sexual side effects or weight gain, as well as having possible mood-stabilizing properties
however it has no efficacy in anxiety, and can actually cause it |
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bupropion
it can increase seizure risk in bulimic patients |
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| this SARI is sleep enhancing and has BID dosage |
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| This NaSSA is a potent H1 blocker, has a rapid onset of action, is sleep-enhancing (duh), however causes weight gain, sedation, dry mouth, and constipation |
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| these two families of antidepressants can be used as anxiolytics as well |
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TCAs and MAOIs
newer ADs are also all effective except bupropion (NDRI) |
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| This anxiolytic is awesome because it has no tolerance issues. It can be used for alcohol withdrawl and works by partial agonism to the 5HT1a receptor |
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| this type of drug is good for social phobias and ptsd |
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andrenergic blockers:
propanol, clonidine, prazosin |
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| use these drugs immediately after traumatic event to impact "kindling" phenomenon |
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