Term
|
Definition
First Line Acute/mixed episode (slow)
2nd Line Bipolar depression
First Line maintenance/prophylaxis
Mech1: Li inhibits phospotases that regenerate PIP2 from used IP3
Mech 2: Li alters GSK-3 via B-catenin
Pharmacokinetics: small Vd, RENAL elim
(theraputic monitor .7= ok 1.5 = death)
Toxicity: nausea/vomiting --> seizure --> coma/renal failure
Contra: decreased renal function
hyponatremia (causes li resorb)
diuretcs
PREGNANT OR NURSING
Adverse: 1. weight gain
2. hypothyroid via TSH-R
3. Hyperthyroid via Ca2
4. Polyuria via ADH ineffect aqua2 |
|
|
Term
| Valproic acid (anti-mania) |
|
Definition
Anti-epileptic
#2 Acute
#2 Depressed
#1 maintenance (still below Li)
Increased GABA @ dendites
Decreased Na axonal transport
Decreaed Ca2+ for vesicle
Decreased Glutamate extracellular
Metabolized by the liver
(may cause pancreatic or hepatic inflam)
NEURAL TUBE DEFECT PREGANNCY |
|
|
Term
|
Definition
Anti-epileptic
#2 prophylaxis only
Blocks Na and CA2+ channels only
SAFE PREGNANCY (may cause cleft)
May cause aseptic meningitis or Stven Johnson syndrome |
|
|
Term
|
Definition
Atypical Antipsychotics
Acute/depressed/maintainence = #1
speculative mechanism
Mania: H1/D1
Depression: a1, D2, 5HT antagonist |
|
|
Term
|
Definition
atypical antipsycotics
assume #1 acute/depressed/maintence
mania: h1/d1 antagonism
depression: a1/d2/5ht antagonist |
|
|
Term
| olanzapine + fluoxitine (anti-mania) |
|
Definition
| atypical antidepres. used for bipolar depression to prevent precip of mixed episode if use only ssri |
|
|
