Term
| WHAT IS THE NAME OF THE DRUG THAT IS A CYCLOOXYGENASE INHIBITOR? |
|
Definition
|
|
Term
|
Definition
| INHIBITS THE SYNTHESIS OF PROSTAGLANDINS AND RELEASE OF PLATELET GRANULES |
|
|
Term
| ASA COVALENTLY ACETYLATES THE ACTIVE SITE ON WHAT ENZYME? WHEN IS COX ENZYME REGENERATED? |
|
Definition
| COX ENZYME. PLATELETS CANNOT REGENERATE NEW COX ENZYMES, SO ONCE ASA HAS INAVTIVATED IT, THE EFFECT LAST FOR THE LIFE OF THE PLATELET (7-10DAYS). MUST MAKE NEW PLATELETS!! |
|
|
Term
|
Definition
|
|
Term
| COX-1 AND COX-2 ARE FOUND WHERE? |
|
Definition
|
|
Term
| WHAT IS THE ANTIPLATELET AND ANTI-INFLAMMATORY DOSE OF ASA? |
|
Definition
| ANTIPLT- 81MG ANTI-INFLAMMATORY- 325-650MG |
|
|
Term
| WHEN SHOULD YOU STOP ASA PRIOR TO SURGERY? |
|
Definition
| 7-10 DAYS WHICH IS THE LIFE OF A PLT |
|
|
Term
| IS THE ONSET OF ASA SLOW OR RAPID? |
|
Definition
|
|
Term
| WHAT IS THE METABOLISM OF ASA? |
|
Definition
| HEPATIC INTO SALICYLIC ACID |
|
|
Term
| WHAT IS THE ELIMINATION OF ASA? WHAT DRUG WOULD WORK BEST WITH ASA OVERDOSE? |
|
Definition
| RENAL. HIGHLY PH DEPENDENET!!!! ALKALINE URINE EXCRETES UP TO 85% OF THE DRUG, WHERE ACIDIC URINE EXCRETES AS LOW AS 5%. |
|
|
Term
| WHAT IS THE PLASMA HALFLIFE OF ASA? WHAT IS THE PLASMA HALFLIFE OF THE METABOLITE SALICYLIC ACID? |
|
Definition
| 20-30 MINUTES FOR ASA. 2-12 HRS FOR SALICYLIC ACID |
|
|
Term
| WHAT ARE 4 SIDE EFFECTS WITH ASA? |
|
Definition
| BLEEDING, GI IRRITATION/BLEEDING/ULCERATION, HEPATIC AND RENAL DAMAGE, ASA-INDUCED ASTHAM (CROSS SENSITIVITY TO TORADOL AND OTHER NSAIDS) SEVERE EXACERBATION IN ASTHMATIC PATIENTS |
|
|
Term
| WHAT IS THE DURATION OF ACTION FOR ASA? |
|
Definition
|
|
Term
| NAME 2 PHOSPHODIESTERASE INHIBITORS? |
|
Definition
| DIPYRIDAMOLE (PERSANTINE) AND CILOSTAZOL (PLETAL) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| HOW DOES PHOSPHODIESTERASE INHIBITORS WORK TO DECREASE PLT AGGREGATION? |
|
Definition
| IN PLTS, INCREASES CAMP (BLOCKS PDE BREAKDOWN OF CAMP). CAUSES VASODILATION WHICH CAN INCREASE CORONARY STEAL AND ANGINA IN SUSCEPTIBLE PATIENTS. CAN BE USED FOR HEART FAILURE |
|
|
Term
| WHAT IS THE HALFLIFE OF DIPYRIDAMOLE AND CILOSTAZOL? |
|
Definition
| DIPYRIDAMOLE IS 10 HRS WHEREAS CILOSTAZOL IS 12 HRS. DIPYRIDAMOLE HAS WEAK ANTIPLT EFFECTS BY ITSELF, SO OFTEN USED IN COMBINATION WITH ASA. |
|
|
Term
| WHAT ARE 4 ADP RECEPTOR INHIBITORS? |
|
Definition
| TICLOPIDINE (TICLID), CLOPIDOGREAL (PLAVIX), PRASUGREL (EFFIENT), AND TRICAGRELOR (BRILINTA) |
|
|
Term
| HOW DOES ADP RECEPTOR INHIBITORS WORK? |
|
Definition
| COVALENTLY AND IRREVERSIBLY BIND TO AND INACTIVATE THE ADP PLT RECEPTOR. DRUG EFFECTS LAST FOR THE LIFE OF THE PLT 7-10 DAYS. |
|
|
Term
| WHEN DOES THE PEAK OF TICLOPIDINE OCCUR ALONE? WITH ASA? |
|
Definition
| 8 DAYS AFTER INITIATION, BUT IN CONJUNCTION WITH ASA THE PEAK IS DECREASED TO 4 DAYS. |
|
|
Term
| IS TICLOPIDINE A PRODRUG? |
|
Definition
| YES, REQUIRES HEPATIC CONVERSION TO ITS ACTIVE FORM |
|
|
Term
| WHAT ARE THE 2 CLINICAL USES OF THE ADP RECEPTOR INHIBITOR? |
|
Definition
| 1) PREVENTION OF THROMBUS IN PTS WHO CANNOT TOLERATE ASA 2) IN COMBINATION WITH ASA FOR PREVENTION OF STENT THROMBUS AFTER CORONARY STENT PLACEMENT. |
|
|
Term
| WHAT ARE 4 SIDE EFFECTS OF TICLOPIDINE? |
|
Definition
| THROMBOCYTOPENIA, TTP, LEUKOPENIA, NAUSEA, DYSPEPSIA |
|
|
Term
| WHAT LAB WORK SHOULD YOU OBTAIN FOR PTS ON TICLIPIDINE? |
|
Definition
|
|
Term
| WHEN SHOULD THE DRUG TICLOPIDINE BE DISCONTINUED PRIOR TO SURGERY? |
|
Definition
|
|
